RESUMO
The experiment has shown the staging of the development of immune response to the chronic fluoride intoxication. Diagnostic criteria of the initial compensation stage are: leukocytosis against the background of reduced number of lymphocytes and increased one of monocytes; high levels of ceruloplasmin in blood plasma, a progressive increase in TNFalpha and cytokine IL-10. At the decompensation stage there are: leukocytosis with increased number of neutrophils; low levels of ceruloplasmin and the cytokines IL-1beta, IL-4 and the high level of TNFalpha, IL-6, IL-10. At the stage of exhaustion there are: leukopenia against the background of lymphocytosis, a high level of Hp, the low values of the level of IgM, IgG.
Assuntos
Citocinas/sangue , Intoxicação por Flúor , Compostos de Flúor , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Contagem de Leucócitos , Animais , Biomarcadores/sangue , Modelos Animais de Doenças , Intoxicação por Flúor/diagnóstico , Intoxicação por Flúor/imunologia , Intoxicação por Flúor/fisiopatologia , Compostos de Flúor/administração & dosagem , Compostos de Flúor/imunologia , Compostos de Flúor/toxicidade , Humanos , Imunidade Celular , Imunidade Humoral , Masculino , Monitorização Imunológica/métodos , Ratos , Fatores de TempoRESUMO
The article covers study concerning influence of coal rock dust and high fluorine concentrations on energy metabolism and oxidation-reduction reactions in blood WBC of experimental rats. The authors demonstrated that the cells vary in response to long action of coal rock dust and high fluorine concentrations.
Assuntos
Poluentes Ocupacionais do Ar/toxicidade , Carvão Mineral/toxicidade , Fluoretos/toxicidade , Exposição por Inalação/efeitos adversos , Leucócitos/efeitos dos fármacos , Animais , Antracossilicose/sangue , Antracossilicose/metabolismo , Membrana Celular/efeitos dos fármacos , Membrana Celular/enzimologia , Membrana Celular/metabolismo , Poeira , Metabolismo Energético/efeitos dos fármacos , Leucócitos/enzimologia , Leucócitos/metabolismo , Masculino , Mitocôndrias/efeitos dos fármacos , Mitocôndrias/enzimologia , Mitocôndrias/metabolismo , Oxirredução , RatosRESUMO
In miners anthracosilicosis is caused by chronic exposure to coal dust and is characterized by progressive development of the inflammatory process, the expressed disorders of lipid metabolism, and immunodeficiency. In the experiment we revealed the stages of anthracosilicosis development according to which adequate measures of prevention and correction of the disorders caused by long exposure of an organism to coal dust are recommended.
