RESUMO
McArdle's Disease is a rare glycogen disease involving deficiency in muscle phosphorylase. This deficiency can lead to rhabdomyolysis and subsequently renal failure. McArdle's Disease has a similar presentation as several other metabolic myopathies with exercise-induced fatigue, myalgias, weakness or unexplained rhabdomyolysis. Suspicion should be raised in the presence of unexplained symptoms, and muscle biopsy can be done to confirm the diagnosis.
Assuntos
Doença de Depósito de Glicogênio Tipo V/diagnóstico , Adulto , Diagnóstico Diferencial , Glicogênio Fosforilase Muscular/metabolismo , Doença de Depósito de Glicogênio Tipo V/fisiopatologia , Humanos , Masculino , Polimiosite/fisiopatologia , Rabdomiólise/fisiopatologiaRESUMO
Anticonvulsant Hypersensitivity Syndrome (AHS) is a rare complication of common drugs used today. It is unusual in that it occurs later than most other drug reactions, about two to six weeks after initiation of the offending agent. It also has a hereditary background unlike most other drug reactions. This reaction is caused by the aromatic amines and causes hepatitis, skin rash, fever, and other systemic organ involvement can occur. The reaction is rare but often fatal, thus the observer should be acutely aware of this in the months following initiation of the agents.
