Impact of tea polyphenols on the stability of oil-in-water emulsions coated by whey proteins.

The ability of tea polyphenols (0, 0.01, 0.02 or 0.04 w/v %) to inhibit lipid and protein oxidation in walnut oil-in-water (O/W) emulsions was examined, as well as to alter their stability to aggregation and creaming. The lipid droplets in these emulsions were coated by whey proteins. The physical stability of the emulsions during storage (50 °C, 96 h) was improved by addition of 0.01% tea polyphenols, but reduced when higher levels were added. Low levels (0.01%) of tea polyphenols inhibited lipid oxidation (lipid hydroperoxide and 2-thiobarbituric acid-reactive substance formation) and protein oxidation (carbonyl and Schiff base formation, sulfhydryl and intrinsic fluorescence loss, and molecular weight changes). However, high levels (0.04%) of tea polyphenols were less effective at inhibiting lipid oxidation, and actually promoted protein oxidation. Tea polyphenols are natural antioxidants that can enhance the quality and shelf life of emulsified polyunsaturated lipids when used at an appropriate concentration.

Analysis of the clinical characteristics of different serotypes of patients with anti-neutrophil cytoplasm antibody-associated vasculitis / 中华风湿病学杂志

Objective This study was aimed to analyze the difference in the clinical features of patients with anti-proteinase-3 anti-neutrophil cytoplasm antibody (PR3-ANCA) and anti-myeloperoxidase (MPO)-ANCA associated vasculitis (AAV);and to discuss the risk factor of relapse.Methods We retrospectively analyzed 103 AAV patients who were diagnosed in Tianjin Medical University General Hospital from January 2010 to May 2016.Based on ANCA serotypes,patients were divided into PR3-ANCA positive,MPO-ANCA positive,both PR3-ANCA and MPO-ANCA negative groups.The difference between the PR3-ANCA and MPO-ANCA groups was analyzed The x2 test and t-test were used for statistical analysis.The Logistic regression analysis was used to evaluate the risk factors of relapse in AAV patients.Results This study included 103 cases of AAV patients,in which,79 (76.7％) patients were with MPO-ANCA and 23 (22.3％) were PR3-ANCA.The MPO-ANCA group had more coronary heart disease than PR3-ANCA group (x2=10.36,P=0.001).The MPO-ANCA group had more pulmonary fibrosis than PR3-ANCA group (x2=12.08,P=0.001).Logistic regres-sion analysis showed that the risk factors of relapse was increase of erythrocyte sedimentation rate (ESR) [OR(95％CI)=9.20(1.06,79.98),P=0.04].Conclusion AAV patients with positive MPO-ANCA and PR3-ANCA are different.