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J Forensic Sci ; 55(2): 315-22, 2010 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-20158590

RESUMO

Genetic information in forensic studies is largely limited to CODIS data and the ability to match samples and assign them to an individual. However, there are circumstances, in which a given DNA sample does not match anyone in the CODIS database, and no other information about the donor is available. In this study, we determined 75 SNPs in 24 genes (previously implicated in human or animal pigmentation studies) for the analysis of single- and multi-locus associations with hair, skin, and eye color in 789 individuals of various ethnic backgrounds. Using multiple linear regression modeling, five SNPs in five genes were found to account for large proportions of pigmentation variation in hair, skin, and eyes in our across-population analyses. Thus, these models may be of predictive value to determine an individual's pigmentation type from a forensic sample, independent of ethnic origin.


Assuntos
Cor de Olho/genética , Cor de Cabelo/genética , Polimorfismo de Nucleotídeo Único , Pigmentação da Pele/genética , Adolescente , Adulto , Proteína Agouti Sinalizadora/genética , Antígenos de Neoplasias/genética , Antiporters/genética , Etnicidade , Genética Forense , Genótipo , Fatores de Troca do Nucleotídeo Guanina/genética , Cabelo/química , Humanos , Modelos Lineares , Melaninas/análise , Proteínas de Membrana Transportadoras/genética , Fenótipo , Ubiquitina-Proteína Ligases
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