[Management of childhood pseudocroup with budesonide inhalation]. / Gyermekkori pseudocroup kezelése inhalativ budesoniddal.

The authors examined 85 children who had serious recurrent pseudogroup syndrome, and re-examined them 1-3 years later. 1/3 of the patients was also allergic, mostly to mites and grasspollens. The patients got either regular, daily two inhalation, or their parents were taught to inspire the drug in the case of stenotic cough of hoarseness. Half of the patients did not answer to our letter. The parents of 43 patients answered and described their observations according to the inquiry letter. 2/3 of treated children either amolioreted definitely of became symptom free. 12 patients had 30 laryngeal attacks before the budesonide treatment whereas only 3 attacks, needing hospitalisation, occurred after the budesonide treatment. 6 patients experienced definite amelioration and two children's state worsened. Budesonide therapy seemed to be useful in the prevention and therapy of recurrent laryngitic children. Further experiences using turbo-inhaler and placebo would be important for more definite statement. Nevertheless inhalative budesonide is the first drug promising fast remission of laryngeal edema.

[Allergologic study of the pathogenesis of atopic dermatitis in infancy and childhood]. / A csecsemö- és gyermekkori atópiás dermatitis kóreredetének allergológiai vizsgálata.

The authors present the results of allergologic investigations in 54 infants and children with atopic dermatitis. To demonstrate the food and inhalative allergies, which are most important etiologic factors in this disease, different methods have been administered. Besides these in vitro and in vivo methods oral food challenges were done to verify the real causative role of the food in question. Food allergy only was verified in 16 cases, 12 patients were suffering in inhalative allergy. Both kind of allergens produced reaction in 19 cases. Among the foods hen egg caused sensibilization most frequently, among the inhalants the house dust mite. In analysing the results the authors want to demonstrate the combined allergic etiology, of atopic dermatitis.

Comparison of ketotifen and DSCG in treatment of food allergy in children.

The authors treated 17 food allergic, 2-14 year old children with chemoprophylactic drugs. The patients got either ketotifen or DSCG in random allocated for 4 weeks and thereafter a washout period of 2 weeks separated the trial period of the other drug. Oral challenge with the food was performed before the trial period and after a 4 week lasting elimination diet on the last day of each treatment. After the ketotifen therapy in 10 of the 17 patients no symptoms appeared after the challenge, whereas only 5 patients were completely protected by DSCG. However, with regards to isolated organ symptoms the two drugs were of equal value. In case of failure of one drug the other was effective with two exceptions. Symptoms of intolerance (vomiting, angioedema or abdominal cramps) occurred in 3 patients during DSCG treatment and in one of those getting ketotifen. In 3 cases of severe milk allergy (Heiner-Holland syndrome) symptom-free state could be attained only if diet was supplemented by ketotifen. Symptoms of food allergy can be well prevented in children through ketotifen therapy more than by DSCG.