RESUMO
Four patients with pseudomyxoma peritonei associated with mucinous tumors of the ovary were treated with cytoreductive surgery followed by intraperitoneal (IP) 5-fluorouracil (5-FU). CA-125 was elevated in three, and ca cinoembryonic antigen (CEA) in one patient; both fell to within normal levels following treatment. Two patients underwent reassessment laparotomy and one a reassessment laparoscopy with no evidence of disease following chemotherapy. The fourth patient refused surgical reassessment but remains clinically free of disease. Intraperitoneal 5-FU appears to be effective in pseudomyxoma peritonei. Précis: Four patients with pseudomyxoma peritonei associated with ovarian tumors were successfully treated with surgery and intraperitoneal 5-FU.
Assuntos
Fluoruracila/uso terapêutico , Neoplasias Ovarianas/tratamento farmacológico , Pseudomixoma Peritoneal/tratamento farmacológico , Adulto , Antígenos Glicosídicos Associados a Tumores/sangue , Antígeno Carcinoembrionário/sangue , Quimioterapia Adjuvante , Feminino , Fluoruracila/administração & dosagem , Humanos , Injeções Intraperitoneais , Pessoa de Meia-Idade , Neoplasias Ovarianas/cirurgia , Pseudomixoma Peritoneal/cirurgia , ReoperaçãoRESUMO
Prophylactic oophorectomy has been recommended in patients with a strongly positive family history for ovarian carcinoma. A patient with a strongly positive family history underwent a prophylactic oophorectomy and, 5 years later, developed a primary peritoneal papillary serous adenocarcinoma. A prophylactic oophorectomy does not afford complete protection in some patients with familial ovarian cancer syndrome. Any tissue derived from the coelomic epithelium may potentially undergo multifocal malignant transformation.
Assuntos
Cistadenocarcinoma/patologia , Neoplasias Ovarianas/prevenção & controle , Ovariectomia , Neoplasias Peritoneais/patologia , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias Ovarianas/genética , Neoplasias Ovarianas/patologiaRESUMO
Eighteen evaluable patients with recurrent or metastatic nonsquamous carcinoma of the uterine cervix were treated with 1,500 micrograms/m2 of echinomycin every 4 weeks. Seven patients had received prior chemotherapy. There was one complete response (5.6%), 95% confidence interval for response of 0-27%. The major toxicity was nausea and vomiting, which was moderate to severe in eight patients. Myelosuppression was minimal. Echinomycin in this dose and schedule displays minimal activity in patients with advanced nonsquamous carcinoma of the cervix.
Assuntos
Equinomicina/uso terapêutico , Neoplasias do Colo do Útero/tratamento farmacológico , Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/secundário , Adulto , Idoso , Carcinoma de Células Pequenas/tratamento farmacológico , Carcinoma de Células Pequenas/secundário , Carcinoma de Células Escamosas/tratamento farmacológico , Carcinoma de Células Escamosas/secundário , Avaliação de Medicamentos , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
This article describes the first reported case of a primary transitional cell carcinoma of the renal pelvis metastatic to the ovary. The clinical presentation in our patient was similar to that of a primary ovarian carcinoma. The differential diagnosis of a primary or metastatic transitional cell carcinoma in the ovary is important and has therapeutic as well as prognostic implications.
Assuntos
Carcinoma de Células de Transição/secundário , Neoplasias Renais , Pelve Renal , Neoplasias Ovarianas/secundário , Carcinoma de Células de Transição/diagnóstico por imagem , Carcinoma de Células de Transição/patologia , Feminino , Humanos , Neoplasias Renais/diagnóstico por imagem , Neoplasias Renais/patologia , Neoplasias Renais/cirurgia , Pessoa de Meia-Idade , Nefrectomia , Neoplasias Ovarianas/diagnóstico por imagem , Neoplasias Ovarianas/patologia , Ovariectomia , Tomografia Computadorizada por Raios XRESUMO
Thirty-three patients with advanced or metastatic endometrial carcinoma were entered in a Phase II trial utilizing methotrexate, 40 mg/m2 intravenously on a weekly basis. Almost all patients had prior total abdominal hysterectomy and almost two-thirds prior pelvic irradiation. No patient had prior chemotherapy. There was one complete and one partial response, for a complete and partial response rate of 6% (95% confidence intervals for a response of 1.7 to 19.6%). Toxicity was mild, with major adverse effects being nausea and vomiting and myelosuppression. One death may have been drug related. Methotrexate displays minimal clinical activity in patients with advanced or recurrent endometrial carcinoma who have received no prior chemotherapy.
Assuntos
Carcinoma/tratamento farmacológico , Metotrexato/uso terapêutico , Neoplasias Uterinas/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma/secundário , Avaliação de Medicamentos , Feminino , Humanos , Metotrexato/administração & dosagem , Metotrexato/toxicidade , Pessoa de Meia-Idade , Estudos Multicêntricos como Assunto , Recidiva Local de Neoplasia/tratamento farmacológico , Indução de RemissãoRESUMO
Two cases of tumor implants occurring in the abdominal trocar sites after diagnostic laparoscopic biopsies of ovarian papillary serous tumors of low malignant potential are presented. To the authors' knowledge, there have been no previous reports to describe tumor implants in the abdominal trocar sites after diagnostic laparoscopic biopsies of ovarian tumors of low malignant potential.
Assuntos
Neoplasias Abdominais/secundário , Carcinoma Papilar/secundário , Laparoscopia/efeitos adversos , Inoculação de Neoplasia , Neoplasias Ovarianas/patologia , Adulto , Biópsia/métodos , DNA de Neoplasias/análise , Feminino , Humanos , Neoplasias Pélvicas/secundárioRESUMO
A 45-year-old female with a unilateral ovarian melanoma without residual ovarian teratoma or clinical evidence of primary lesion is described. The clinical and pathological differential diagnosis is discussed.