Replication of the associations of positive, negative, and disorganized schizotypy with interview-assessed symptoms and impairment: Convergence with previous studies.

Schizophrenia-spectrum psychopathology appears best understood as being expressed across a continuum of clinical and subclinical symptoms and impairment referred to as schizotypy. This brief report describes a comprehensive replication study examining the associations of positive, negative, and disorganized schizotypy with interview ratings of impairment, psychopathology, and personality pathology in a sample of 161 young adults. Consistent with past studies, positive, negative, and disorganized schizotypy had distinct and hypothesized associations with symptoms and impairment. Positive schizotypy was associated with prodromal symptoms and schizotypal, paranoid, and borderline personality traits. Negative schizotypy was associated with impaired functioning, negative symptoms, and schizoid, schizotypal, and paranoid traits, as well as any broad personality disorder diagnosis; it was also associated with never having dated. Disorganized schizotypy was associated with impaired functioning, disorganized schizotypic experiences, attentional deficits, and schizotypal, paranoid, borderline, and avoidant personality traits, as well as depression. Overall, we successfully replicated findings from five previous schizotypy interview studies, supporting the construct validity of the multidimensional model of schizotypy and the Multidimensional Schizotypy Scale. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Affective dynamics in daily life are differentially expressed in positive, negative, and disorganized schizotypy.

Schizotypy and schizophrenia are associated with disruptions in the experience of affect. Temporal patterns of affect, or affective dynamics, offer unique information about the expression of multidimensional schizophrenia-spectrum psychopathology. The present study employed experience sampling methodology to examine affective intensity, inertia, variability, reactivity, and instability in positive, negative, and disorganized schizotypy in nonclinically ascertained young adults (n = 275). As hypothesized, disorganized schizotypy demonstrated the most robust associations with affective dynamics and was characterized by elevated intensity, reactivity, and variability of negative affect. Disorganized schizotypy was also associated with instability of negative affect, but this relation was better accounted for by mean negative affect, which was elevated in disorganized schizotypy. Negative schizotypy was characterized by diminished intensity and variability of positive affect as expected, but was unassociated with affective inertia. Finally, as hypothesized, positive schizotypy was associated with elevated intensity and variability of negative affect at the bivariate level, but was unassociated with affective dynamics when including disorganized schizotypy in the model. These findings indicate that the schizotypy dimensions are differentiated by both mean levels and dynamics of affect, and that affective dynamics convey unique information about multidimensional schizotypy beyond mean levels of affect. The findings provide further support for the multidimensional model of schizotypy. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Association of Multidimensional Schizotypy with PID-5 Domains and Facets.

The underlying vulnerability for schizophrenia-spectrum disorders is expressed across a continuum of clinical and subclinical symptoms referred to as schizotypy. Schizotypy is a multidimensional construct with positive, negative, and disorganized dimensions. The present study examined associations of positive, negative, and disorganized schizotypy with pathological personality traits and facets assessed by the Personality Inventory for DSM-5 (PID-5) in 1,342 young adults. As hypothesized, positive schizotypy was associated with the PID-5 psychoticism domain and facets, negative schizotypy was associated with the detachment domain and facets and the restricted affectivity facet, and disorganized schizotypy's strongest associations were with the distractibility and eccentricity facets and the negative affect domain. The PID-5 facets accounted for upwards of two thirds of the variance in each schizotypy dimension. The authors conclude by providing regression-based algorithms for computing positive, negative, and disorganized schizotypy scores based on the PID-5 facets.

The association of multidimensional schizotypy with symptoms and impairment across racial groups.

The assessment of schizotypy and schizophrenia-spectrum psychopathology has historically been adversely impacted by multiple forms of measurement bias, including racial bias. The Multidimensional Schizotypy Scale (MSS) was developed using modern scale construction methods to minimize measurement bias in the assessment of schizotypic traits. However, studies have not examined the validity of the measurement across different racial groups. The present study examined whether the associations of MSS positive, negative, and disorganized schizotypy subscales with interview-assessed ratings of functioning, schizophrenia-spectrum personality traits, and depressive disorders were generally comparable across nonclinically ascertained samples of Black (n = 46), Asian (n = 87), and White (n = 116) young adults. Consistent with previous findings, all three schizotypy subscales were associated with impairment and schizotypal and paranoid traits. Negative schizotypy was associated with schizoid traits, and disorganized schizotypy was associated with depressive disorders. These associations were comparable across the racial groups, supporting the use of the MSS in these groups. Culturally and empirically valid assessments are essential for providing accurate assessments across racial/ethnic groups and reducing the risk of overpathologizing people of color. The present findings support the cross-cultural validity of the MSS; however, future studies should expand upon these findings by including more diverse samples and longitudinal designs.

Association of positive, negative, and disorganized schizotypy with cluster a, borderline, and avoidant personality disorders and traits.

The present study examined the associations of positive, negative, and disorganized schizotypy dimensions assessed by the Multidimensional Schizotypy Scale with 5 interview-rated personality disorder diagnoses and traits in 151 young adults. As hypothesized, all 3 schizotypy dimensions were associated with impaired functioning. Positive schizotypy was associated with schizotypal and borderline personality traits; negative schizotypy was associated with schizotypal, schizoid, paranoid, and avoidant personality traits; and disorganized schizotypy was associated with paranoid, borderline, and avoidant personality disorder traits. Negative schizotypy predicted broad diagnoses of Cluster A personality disorders. Both negative and disorganized schizotypy predicted the broad diagnosis of any of the 5 personality disorders. The study further examined the association of the schizotypy dimensions with the individual personality disorder criteria to better understand the overall associations. Given the common origins and high comorbidity, we examined whether the schizotypy dimensions explained the association of borderline and schizotypal personality disorder traits. Positive and disorganized schizotypy fully mediated the association between borderline and schizotypal traits. In summary, the study replicated and extended previous findings that the schizotypy dimensions are uniquely associated with personality disorders and traits, as well as impaired functioning, in young adults. The study also provided additional support for the construct validity of the Multidimensional Schizotypy Scale and for the use of psychometric assessment of schizotypy. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Positive, Negative, and Disorganized Schizotypy Predict Differential Patterns of Interview-Rated Schizophrenia-Spectrum Symptoms and Impairment.

The present study assessed the construct validity of the Multidimensional Schizotypy Scale (MSS). Specifically, it assessed the associations of the MSS positive, negative, and disorganized schizotypy subscales with interview-rated symptoms and impairment in 177 young adults. As hypothesized, the MSS positive schizotypy subscale was associated with interview-rated positive symptoms, and schizotypal and paranoid personality traits. Negative schizotypy was associated with interview-rated negative symptoms, and schizotypal and schizoid traits, and elevated rates of schizophrenia-spectrum personality disorders. Disorganized schizotypy was associated with disorganized symptoms and attentional deficits. All three subscales were associated with impaired functioning. This was the first study to evaluate the validity of the MSS using interview measures. The findings indicate that the schizotypy dimensions are associated with unique patterns of symptoms and impairment, and support the validity of the MSS.

A brief questionnaire measure of multidimensional schizotypy predicts interview-rated symptoms and impairment.

The present study employed structured diagnostic interviews to assess the construct validity of the brief version of the Multidimensional Schizotypy Scale (MSS-B), which was developed to assess positive, negative, and disorganized dimensions of schizotypy. It was hypothesized that the MSS-B subscales would be associated with differential patterns of symptoms and impairment, comparable to findings for the full-length MSS. A total of 177 young adults completed structured diagnostic interviews assessing symptoms and impairment. As hypothesized, MSS-B positive schizotypy was significantly associated with interview ratings of positive (psychotic-like) symptoms, as well as schizotypal and paranoid personality disorder traits. MSS-B negative schizotypy was associated with interview ratings of negative symptoms, as well as schizoid, paranoid, and schizotypal traits. Furthermore, negative schizotypy predicted Cluster A personality disorder diagnoses. MSS-B disorganized schizotypy was associated with interview ratings of disorganized symptoms. All three schizotypy dimensions were associated with impaired functioning. This was the first study to evaluate the validity of the MSS-B using interview measures, and the pattern of findings for each MSS-B subscale was closely comparable to the findings for the full-length MSS. Contrary to our hypothesis, cannabis use was largely unassociated with psychotic-like symptoms and did not moderate the expression of the schizotypy dimensions. The MSS-B has good psychometric properties, high concordance with the full-length MSS, and good construct validity. Thus, it appears to be a promising brief alternative to traditional schizotypy measures.

Association of multidimensional schizotypy with psychotic-like experiences, affect, and social functioning in daily life: Comparable findings across samples and schizotypy measures.

The present study examined the associations of positive, negative, and disorganized schizotypy with psychotic-like experiences, affect, and social functioning in daily life using experience sampling methodology (ESM) in 2 samples (ns = 165 and 203) that employed different measures of schizotypy. Schizotypy is a useful framework for understanding schizophrenia-spectrum psychopathology, and ESM offers a powerful approach for assessing schizotypy in real-world settings. Participants were signaled 8 times daily for 7 days to complete ESM questionnaires. As hypothesized, positive schizotypy was robustly associated with psychotic-like experiences in daily life, whereas negative schizotypy was associated with negative experiences, diminished positive affect, and social disinterest in both samples. As expected, disorganized schizotypy was associated with disorganization in daily life. Furthermore, it was associated with increased negative affect and diminished positive affect. Thus, positive, negative, and disorganized schizotypy were associated with unique, hypothesized patterns of experiences in daily life, and the findings across the two samples and two schizotypy measures were strikingly consistent. Note that when disorganized schizotypy was not entered as a predictor in the 2 samples, disorganized experiences and negative affect in daily life were associated with positive schizotypy. However, when disorganized schizotypy was included as a predictor, these daily life experiences were associated with disorganized, not positive, schizotypy. This is similar to findings from interview and questionnaire studies that have simultaneously assessed positive, negative, and disorganized schizotypy. The findings support the construct validity of the multidimensional model of schizotypy and the importance of including disorganization in the conceptualization and assessment of schizotypy. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Psychometric Properties of the Multidimensional Schizotypy Scale and Multidimensional Schizotypy Scale-Brief: Item and Scale Test-Retest Reliability and Concordance of Original and Brief Forms.

We conducted 2 studies examining the psychometric properties of the Multidimensional Schizotypy Scale (MSS) and the Multidimensional Schizotypy Scale-Brief (MSS-B). These studies offered the first examination of the scales' test-retest reliability (dependability), impact of testing interval on test-retest reliability, and concordance of the 2 versions. The MSS and MSS-B contain positive, negative, and disorganized schizotypy subscales that reflect current models of schizotypy. In Study 1, MTurk participants (n = 245) completed the scales at 2 assessments across a 7-week time interval. Test-retest reliabilities (intraclass correlations) ranged from .84 to .90 for the MSS subscales and from .77 to .85 for the MSS-B subscales, and were unaffected by the interval length between administrations. The association between the same subscales of the MSS and MSS-B across the 2 assessments ranged from .79 to .87, indicating good correspondence between the MSS and MSS-B. Scores on the MSS-B subscales in Study 1 were derived from the full-length MSS. Therefore, we replicated the findings using the actual MSS-B subscales in Study 2 in 3 samples (total n = 339). The results indicated that the MSS and MSS-B have good internal consistency and test-retest reliabilities (dependability), and that there is high concordance between the full-length and brief versions.

Using multiple measures of openness to experience to capture positive, negative, and disorganized dimensions of schizotypy.

The underlying vulnerability for schizophrenia-spectrum disorders is expressed across a continuum of clinical and subclinical symptoms and impairment known as schizotypy. Schizotypy is a multidimensional construct with positive, negative, and disorganized dimensions. Models of normal personality provide useful frameworks for examining the multidimensional structure of schizotypy. However, the relationship of schizotypy with openness to experience has been largely limited to studies using the five-factor model of personality, which may not adequately capture maladaptive expressions of openness. Therefore, this study examined the relationship of positive, negative, and disorganized schizotypy with multiple measures of openness that capture adaptive and maladaptive aspects of the construct. MTurk and university participants (n = 1,281) completed the Multidimensional Schizotypy Scale and five measures of openness. As hypothesized, positive schizotypy was generally associated with elevated openness, especially measures tapping oddness and eccentricity, whereas negative schizotypy was inversely associated with openness, especially measures assessing openness to feelings. Disorganized schizotypy was generally unassociated with openness. Principal components analysis of 15 openness facets revealed four factors: Fantasy/Feelings, Ideas, Eccentricity, and Nontraditionalism, and provided more nuanced understanding of the associations of schizotypy and openness. Positive schizotypy was associated with each factor (albeit inversely with Nontraditionalism), negative schizotypy was inversely associated with Fantasy/Feelings but positively associated with Eccentricity, and disorganized schizotypy was only associated with Eccentricity. These results support the construct validity of the Multidimensional Schizotypy Scale and highlight that the association of schizotypy and openness is best understood by considering the multidimensionality of both constructs and evaluating adaptive and maladaptive openness. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Association of positive, negative, and disorganized schizotypy dimensions with affective symptoms and experiences.

Schizotypy offers a useful construct for investigating the etiology, development, and expression of schizophrenia-spectrum psychopathology, as well as the comorbid expression of mood and anxiety disorders across the schizophrenia spectrum. The present study examined the associations of positive, negative, and disorganized schizotypy with affective symptoms and experiences in a sample of MTurk workers and college students (n = 575). Participants completed the Multidimensional Schizotypy Scale (MSS) and measures of depression, anxiety, social phobia, hypomanic traits, and state affect. As expected, positive schizotypy was significantly associated with hypomanic traits, whereas negative schizotypy was associated with reduced positive affect and reduced hypomanic traits. Although prior research has emphasized the association of positive schizotypy with depression and anxiety, the current results demonstrate that disorganized schizotypy is more strongly associated with elevated negative affect (over-and-above positive schizotypy). As such, these findings highlight the importance of examining disorganization of affect, in addition to the cognitive-behavioral deficits traditionally associated with disorganized schizotypy. Finally, the MSS and MSS-Brief demonstrated closely comparable findings. The present results provide further support for the construct validity of the MSS and the three-factor model of schizotypy.

Neural correlates of social cognitive introspective accuracy in schizophrenia.

Introspective accuracy (IA) refers to the ability to accurately assess one's own skills and capabilities. Recent work provides evidence of IA deficits in schizophrenia that are predictive of everyday functioning. Thus, IA deficits are an important target to understand mechanistically. The current study used fMRI to assess neural activation in 32 healthy controls and 31 individuals with schizophrenia as they completed IA and control versions of a social cognitive task (i.e., emotion recognition). Analyses revealed different areas of IA-specific neural activity between groups including activations of rostrolateral prefrontal cortex (rlPFC) and dorsal anterior cingulate cortex in healthy individuals that were absent in patients. Direct group comparisons revealed greater IA-specific activation for healthy individuals in right rlPFC, a region thought to be critical for successful IA. For healthy individuals only, activation in rlPFC was positively correlated with IA ability, but no association was observed for patients. Further, among individuals with schizophrenia, increased activation of rlPFC during judgments of IA was positively correlated with better informant-reported interpersonal functioning. These results suggest that reduced specialization of IA-related neural activation may contribute to impaired IA in schizophrenia and also highlight IA as a potential target for remediation programs aimed at improving real-world functioning.