RESUMO
A 58-year-old woman presented with typical cutaneous features of lichen planus (LP). She had suffered from vulval pruritus for 3 years, and examination showed lesions suggestive of LP on the vulva. Three months later a plaque developed on the clitoral hood, and biopsy showed an invasive squamous carcinoma. After vulvectomy, features of LP were found in the excised specimen. Vulval LP should be carefully monitored for possible malignant transformation.
Assuntos
Carcinoma de Células Escamosas/etiologia , Líquen Plano/complicações , Doenças da Vulva/patologia , Neoplasias Vulvares/etiologia , Biópsia , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Feminino , Humanos , Líquen Plano/tratamento farmacológico , Líquen Plano/patologia , Pessoa de Meia-Idade , Doenças da Vulva/terapia , Neoplasias Vulvares/patologia , Neoplasias Vulvares/cirurgiaRESUMO
Fifty-four patients taking minocycline for acne or rosacea were assessed for adverse effects. Their mean duration of treatment was 17 months, and their average cumulative dose was 47 g. No symptoms attributable to the therapy were reported. Biochemistry and haematology profiles were normal. There was no evidence of an adverse effect on thyroid function. Skin pigmentation was detected in eight patients (14.8%). Five patients had diffuse facial pigmentation, and three patients had localized pigmentation at the site of a scar or injury. Diffuse pigmentation occurred only in patients who had been on treatment for 3 years or more; 50% of such patients were affected. Age and solar damage may also have been factors in this type of pigmentation. Localized pigmentation occurred at sites of previous tissue damage, and was not directly related to the duration of therapy. Patients who receive long-term minocycline therapy should be regularly monitored for the development of pigmentation.
Assuntos
Dermatoses Faciais/tratamento farmacológico , Minociclina/efeitos adversos , Transtornos da Pigmentação/induzido quimicamente , Acne Vulgar/tratamento farmacológico , Adolescente , Adulto , Fatores Etários , Idoso , Cicatriz/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Minociclina/administração & dosagem , Transtornos da Pigmentação/patologia , Rosácea/tratamento farmacológico , Envelhecimento da Pele , Pigmentação da Pele/efeitos dos fármacos , Glândula Tireoide/efeitos dos fármacos , Tireotropina/sangue , Tiroxina/análise , Fatores de TempoRESUMO
A 10-year-old boy reacted to aluminium Finn Chambers during routine patch testing. Further patch tests with aqueous aluminium chloride confirmed contact allergy to aluminium. The boy's 8-year-old brother also reacted to aluminium Finn Chambers. Both boys had suffered from a scaling eruption on their face and limbs since infancy.
Assuntos
Alumínio/efeitos adversos , Dermatite Alérgica de Contato/genética , Criança , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/etiologia , Humanos , Masculino , Testes do EmplastroRESUMO
We present a case of erysipelas which complicated chronic discoid lupus erythematosus (CDLE) of the face. The diagnosis and implications for management are discussed. The changing epidemiology and clinical spectrum of erysipelas are reviewed.
Assuntos
Erisipela/etiologia , Lúpus Eritematoso Discoide/complicações , Idoso , Humanos , MasculinoRESUMO
In a prospective study of thirty-seven infants presenting with dermatitis in infancy it was found that pruritus, a positive family history of atopy, and the age of onset of skin lesions were of little value in distinguishing atopic dermatitis from infantile seborrhoeic dermatitis. The most useful distinguishing features were the increased incidence of lesions on the forearms and shins in atopic dermatitis, and in the axillae in infantile seborrhoeic dermatitis. The onset of skin lesions solely in the napkin area favoured a diagnosis of infantile seborrhoeic dermatitis, but when more than one site was involved the distinction was less clear. Infantile seborrhoeic dermatitis carried a much better prognosis than atopic dermatitis. In thirty-six out of thirty-seven infants the definitive diagnosis could be made with confidence on clinical grounds by the age of I year, but was often difficult at first presentation in early infancy.
Assuntos
Dermatite Atópica/diagnóstico , Dermatite Seborreica/diagnóstico , Diagnóstico Diferencial , Feminino , Humanos , Hipersensibilidade Imediata/genética , Lactente , Recém-Nascido , Doenças do Recém-Nascido/diagnóstico , Masculino , Prognóstico , Estudos ProspectivosRESUMO
Total and antigen-specific IgE levels using the radioallergosorbent test (RAST) were measured in a prospective study of thirty-seven infants with dermatitis of early infancy, with the aim of distinguishing between atopic and infantile seborrhoeic dermatitis at an earlier age than is usually possible on clinical grounds. The results were correlated with the clinical diagnoses made after 1-2 years close follow-up. They showed that a RAST screen to egg white and to milk antibodies, and to a lesser extent total IgE levels, are of value in diagnosing atopic dermatitis at an early age and distinguishing this from infantile seborrhoeic dermatitis.
