1.
Annu Int Conf IEEE Eng Med Biol Soc
; 2007: 5976-9, 2007.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18003375
RESUMO
A computational model based on finite element method is derived to examine how the simulated time-dependent signals are related to the presence of residual fluorescence in biological media surrounding a fluorescent object. We apply a subtraction technique on recorded data when imperfect uptake of fluorescing agent into the tumor is considered. We show the limits of the subtracting method for low target: background fluorescent absorption contrast by extracting the time to reach the half maximum and analyzing the maximum of the time-resolved signals versus target depth.