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1.
Eur Ann Allergy Clin Immunol ; 51(6): 265-273, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31287261

RESUMO

Summary: This study was aimed to reveal the prevalence of dog allergy and other common allergy and allergic symptoms in police dog trainers. Fifty-six police dog trainers and 150 workers as control group were included in this study. Medical records of dog trainers including respiratory, skin, eye symptoms and physical examinations and skin prick test results are compared with the medical records of control group. Positive SPT to dog was present in 21.4% of dog trainers, whereas the frequency of sensitization to dog in the control group was 1.3% (p minor 0.001). Dog allergy development risk is found 20 times greater in dog trainers than control group. In multiple logistic regression analysis, it was found that atopy was associated with dog allergy likelihood. Sensitization to dog allergens is an important occupational problem for dog trainers.


Assuntos
Pelo Animal/imunologia , Cães , Hipersensibilidade Imediata/epidemiologia , Doenças Profissionais/epidemiologia , Adulto , Animais , Feminino , Humanos , Masculino , Doenças Profissionais/imunologia , Polícia/estatística & dados numéricos , Testes Cutâneos/métodos
2.
J Laryngol Otol ; 133(6): 466-476, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31099325

RESUMO

OBJECTIVE: To investigate whether oxytocin can prevent ototoxicity related to acoustic trauma. METHODS: Twenty-eight rats were divided into four groups: noise (group 1), control (group 2), noise plus oxytocin (group 3), and oxytocin (group 4). Intratympanic oxytocin was administered on days 1, 2, 4, 6, 8 and 10 in groups 3 and 4. Groups 1 and 3 were exposed to acoustic trauma. Distortion product otoacoustic emission and auditory brainstem response testing were performed in all groups. RESULTS: In group 1, auditory brainstem response thresholds increased significantly after acoustic trauma. In group 3, auditory brainstem response thresholds increased significantly on day 1 after acoustic trauma, but there were no significant differences between thresholds at baseline and on the 7th and 21st days. In group 1, significant differences were observed between distortion product otoacoustic emission signal-to-noise ratios measured before and on days 1, 7 and 21 after acoustic trauma. In group 3, no significant differences were observed between the distortion product otoacoustic emission signal-to-noise ratios measured before and on days 7 and 21 after acoustic trauma. CONCLUSION: Oxytocin had a therapeutic effect on rats exposed to acoustic trauma in this experiment.


Assuntos
Perda Auditiva Provocada por Ruído/tratamento farmacológico , Perda Auditiva Provocada por Ruído/patologia , Ocitocina/farmacologia , Membrana Timpânica/efeitos dos fármacos , Animais , Biópsia por Agulha , Modelos Animais de Doenças , Potenciais Evocados Auditivos do Tronco Encefálico/efeitos dos fármacos , Perda Auditiva Provocada por Ruído/diagnóstico , Imuno-Histoquímica , Injeções Intralesionais , Masculino , Emissões Otoacústicas Espontâneas/efeitos dos fármacos , Distribuição Aleatória , Ratos , Ratos Sprague-Dawley , Valores de Referência , Razão Sinal-Ruído , Estatísticas não Paramétricas , Resultado do Tratamento
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