RESUMO
Nowadays, development of highly efficient potentiometric sensors attracts the attention of many researchers over the world; due to the great expansion of portable analytical devices. This study aims to apply a current development to the construction and sense of carbon paste sensors based on flowered-like Mg-Al layered double hydroxides/multiwalled carbon nanotubes (FLLDH/MWCNTs) (sensor Ð), FLLDH/titanate nanotubes (TNTs) (sensor ÐÐ) and MWCNTs/TNTs (sensor ÐÐÐ) nanocomposites for bambuterol hydrochloride analysis; to enhance the potentiometric response towards determination of the drug. The sensors exhibited excellent Nernstian slopes 58.8⯱â¯0.5, 58.5⯱â¯0.8 and 57.4⯱â¯0.7â¯mV/decade with linear working ranges of 1.0â¯×â¯10-7-1.0â¯×â¯10-2, 1.0â¯×â¯10-6-1.0â¯×â¯10-2 and 1.0â¯×â¯10-7-1.0â¯×â¯10-2â¯molâ¯L-1, detection limits 2.3â¯×â¯10-8, 2.5â¯×â¯10-7and 7.5â¯×â¯10-8â¯molâ¯L-1 and quantification limits of 7.6â¯×â¯10-8, 8.3â¯×â¯10-7and 2.5â¯×â¯10-7â¯molâ¯L-1 for sensor Ð, ÐÐ and ÐÐÐ, respectively. The selectivity behaviour of the investigated sensors was tested against biologically important blood electrolytes (Na+, K+, Mg2+, Ca2+). The proposed analytical method was successfully applied for BAM determination in pure drug, pharmaceutical products, surface water, human plasma and urine samples with excellent recovery data (99.62, 99.10 and 98.95%) for the three sensors, respectively.