Reduced spatial attentional distribution in older adults.

Older adults show decline in visual search performance, but the underlying cause remains unclear. It has been suggested that older adults' altered performance may be related to reduced spatial attention to peripheral visual information compared with younger adults. In this study, 18 younger (M = 21.6 years) and 16 older (M = 69.1 years) participants performed pop-out and serial visual search tasks with variously sized gaze-contingent artificial central scotomas (3°, 5°, or 7° diameter). By occluding central vision, we measured how attention to the periphery was contributing to the search performance. We also tested the effect of target eccentricity on search times and eye movements. We hypothesized that, if attention is reduced primarily in the periphery in older adults, we would observe longer search times for more eccentric targets and with central occlusion. During the pop-out search, older adults showed a steeper decline in search performance with increasing eccentricity and central scotoma size compared with younger adults. In contrast, during the serial search, older adults had longer search times than younger adults overall, independent of target eccentricity and scotoma size. Longer search times were attributed to higher cost-per-item slopes, indicating increased difficulty in simultaneously processing complex symbols made up of separable features in aging, possibly stemming from challenges in spatially binding individual features. Altogether, our findings point to fewer attentional resources of simultaneous visual processing to distribute over space or separable features of objects, consistent with decreased dorsal visual stream functioning in aging.

Attentional limits in visual search with and without dorsal parietal dysfunction: space-based window or object-based span?

Attentional resource and distribution are specifically impaired in simultanagnosia, and also in the visuo-attentional form of developmental dyslexia. Both clinical conditions are conceived as a limitation of simultaneous visual processing after superior parietal lobule (SPL) dysfunction (review in Valdois et al., 2019). However, a reduced space-based attentional window (i.e. a limited visual eccentricity at which the target object can be identified, Khan et al. 2016) has been demonstrated in simultanagnosia versus a reduced object-based span (i.e. a limited number of objects processed at each fixation, Bosse et al., 2007) in developmental dyslexia. In healthy individuals, the cost in reaction times per item in serial search tasks suggests that a group of objects is processed simultaneously at a time, but this group is also undefined and depends on the visual complexity of the task. Healthy individuals and a patient with simultanagnosia performed serial search tasks involving either symbols (made of separable features) or objects made of non-separable features, and with distractors that were either all identical or all dissimilar. We used a moving window paradigm to determine whether the task was performed with a "working space" versus a "working span" limitation in control group and in patient with bilateral SPL damage. We found that healthy individuals performed search in a color task comprising non-separable feature objects and dissimilar distractors with a limited space-based attentional window; this attentional window, as well as the mean saccade amplitude used to displace it across the visual display, were independent of set size, thus inconsistent with an object-based attentional span. In the symbol task comprising a feature-absent search in which all feature-present distractors were dissimilar, we observed that mean saccade amplitude decreased with set size and that search performance could not be mimicked by a moving window of a single diameter; instead participants seemed to process a fixed number of symbols at a time (object-based span). Following bilateral SPL lesions, patient IG demonstrated a similar space-based search process in the color search task with a normal attentional window. In contrast, her cost-per-item in the symbol task increased dramatically, demonstrating a clear deficit of simultaneous object perception. These results confirmed the specific contribution of the SPL to the visual processing of multiple objects made of separable features (like letters), and more dramatically when they are all different, which explains the specific difficulty for a reading beginner in case of SPL dysfunction.

Post-saccadic changes disrupt attended pre-saccadic object memory.

Trans-saccadic memory consists of keeping track of objects' locations and features across saccades; pre-saccadic information is remembered and compared with post-saccadic information. It has been shown to have limited resources and involve attention with respect to the selection of objects and features. In support, a previous study showed that recognition of distinct post-saccadic objects in the visual scene is impaired when pre-saccadic objects are relevant and thus already encoded in memory (Poth, Herwig, Schneider, 2015). Here, we investigated the inverse (i.e. how the memory of pre-saccadic objects is affected by abrupt but irrelevant changes in the post-saccadic visual scene). We also modulated the amount of attention to the relevant pre-saccadic object by having participants either make a saccade to it or elsewhere and observed that pre-saccadic attentional facilitation affected how much post-saccadic changes disrupted trans-saccadic memory of pre-saccadic objects. Participants identified a flashed symbol (d, b, p, or q, among distracters), at one of six placeholders (figures "8") arranged in circle around fixation while planning a saccade to one of them. They reported the identity of the symbol after the saccade. We changed the post-saccadic scene in Experiment one by removing the entire scene, only the placeholder where the pre-saccadic symbol was presented, or all other placeholders except this one. We observed reduced identification performance when only the saccade-target placeholder disappeared after the saccade. In Experiment two, we changed one placeholder location (inward/outward shift or rotation re. saccade vector) after the saccade and observed that identification performance decreased with increased shift/rotation of the saccade-target placeholder. We conclude that pre-saccadic memory is disrupted by abrupt attention-capturing post-saccadic changes of visual scene, particularly when these changes involve the object prioritized by being the goal of a saccade. These findings support the notion that limited trans-saccadic memory resources are disrupted when object correspondence at saccadic goal is broken through removal or location change.

Bálint syndrome.

This chapter starts by reviewing the various interpretations of Bálint syndrome over time. We then develop a novel integrative view in which we propose that the various symptoms, historically reported and labeled by various authors, result from a core mislocalization deficit. This idea is in accordance with our previous proposal that the core deficit of Bálint syndrome is attentional (Pisella et al., 2009, 2013, 2017) since covert attention improves spatial resolution in visual periphery (Yeshurun and Carrasco, 1998); a deficit of covert attention would thus increase spatial uncertainty and thereby impair both visual object identification and visuomotor accuracy. In peripheral vision, we perceive the intrinsic characteristics of the perceptual elements surrounding us, but not their precise localization (Rosenholtz et al., 2012a,b), such that without covert attention we cannot organize them to their respective and recognizable objects; this explains why perceptual symptoms (simultanagnosia, neglect) could result from visual mislocalization. The visuomotor symptoms (optic ataxia) can be accounted for by both visual and proprioceptive mislocalizations in an oculocentric reference frame, leading to field and hand effects, respectively. This new pathophysiological account is presented along with a model of posterior parietal cortex organization in which the superior part is devoted to covert attention, while the right inferior part is involved in visual remapping. When the right inferior parietal cortex is damaged, additional representational mislocalizations across saccades worsen the clinical picture of peripheral mislocalizations due to an impairment of covert attention.

Saccadic adaptation in the presence of artificial central scotomas.

Saccadic adaptation can occur over a short period of time through a constant adjustment of the saccade target during the saccade, resulting in saccadic re-referencing, which directs the saccade to a location different from the target that elicited the saccade. Saccade re-referencing could be used to help patients with age-related macular degeneration to optimally use their residual visual function. However, it remains unknown whether saccade adaptation can take place in the presence of central scotomas (i.e., without central vision). We tested participants in two experiments in a conventional double-step paradigm with a central gaze-contingent artificial scotoma. Experiment 1 (N = 12) comprised a backward adaptation paradigm with no scotoma control, visible, and invisible 3° diameter scotoma conditions. Experiment 2 (N = 13) comprised a forward adaptation paradigm with no scotoma control, invisible 2°, and 4° diameter scotoma conditions. In Experiment 1, we observed significant adaptation in both the visible and invisible scotoma conditions comparable to the control condition with no scotoma. This was the case even when the saccade landed such that the target was occluded by the scotoma. We observed that adaptation occurred based on peripheral viewing of the stepped target during the deceleration period. In Experiment 2, we found that both scotoma conditions showed adaptation again comparable to the control condition with no scotoma. We conclude that saccadic adaptation can occur with central scotomas, showing that it does not require central vision and can be driven primarily by peripheral retinal error.

Changes in eye movement parameters in the presence of an artificial central scotoma.

BACKGROUND: Central vision loss, such as in the case of age-related macular degeneration (AMD), has a a major negative impact on patients' quality of life. However, some patients have shown spontaneous adaptive strategies development, mostly relying on their peripheral vision. OBJECTIVE: This study assesses eye movement and eccentric visual function adaptive behaviors of a healthy population in the presence of simulated central vision loss. We wished to determine how central vision loss affects eye movements, specifically the foveal-target alignment. METHODS: Fifteen healthy participants (7 females, M = 21.69, SD = 2.13) discriminated the orientation of a Gabor relative to the vertical located at 12 deg of eccentricity to the right of fixation, in the presence of a gaze-contingent artificial central scotoma either visible or invisible. The artificial central scotoma was 4° diameter in order to simulate an earlier stage of degenerative disease while still impairing foveal vision. The target's orientation varied between 10° counter-clockwise and 10° clockwise. Each participant performed four blocks of 75 trials each per day over 10 days, the first day being a baseline without scotoma. RESULTS: We found changes in the endpoints of the 1st saccade over the practice days. The most common pattern was a gradual upward shift. We also observed a significant increase in discrimination performance over the 9 days of practice. We did not find any difference linked to the scotoma types. CONCLUSIONS: These findings suggest that the presence of an artificial central scotoma combined with a challenging discrimination task induces both changes in saccade planning mechanisms, resulting in a new eccentric-target alignment, and improvements in eccentric visual functions. This demonstrates the potential of this research paradigm to understand and potentially improve visual function in patients with central vision loss.

Anti-saccades predict cognitive functions in older adults and patients with Parkinson's disease.

A major component of cognitive control is the ability to act flexibly in the environment by either behaving automatically or inhibiting an automatic behaviour. The interleaved pro/anti-saccade task measures cognitive control because the task relies on one's abilities to switch flexibly between pro and anti-saccades, and inhibit automatic saccades during anti-saccade trials. Decline in cognitive control occurs during aging or neurological illnesses such as Parkinson's disease (PD), and indicates decline in other cognitive abilities, such as memory. However, little is known about the relationship between cognitive control and other cognitive processes. Here we investigated whether anti-saccade performance can predict decision-making, visual memory, and pop-out and serial visual search performance. We tested 34 younger adults, 22 older adults, and 20 PD patients on four tasks: an interleaved pro/anti-saccade, a spatial visual memory, a decision-making and two types of visual search (pop-out and serial) tasks. Anti-saccade performance was a good predictor of decision-making and visual memory abilities for both older adults and PD patients, while it predicted visual search performance to a larger extent in PD patients. Our results thus demonstrate the suitability of the interleaved pro/anti-saccade task as a cognitive marker of cognitive control in aging and PD populations.

A nonvisual eye tracker calibration method for video-based tracking.

Video-based eye trackers have enabled major advancements in our understanding of eye movements through their ease of use and their non-invasiveness. One necessity to obtain accurate eye recordings using video-based trackers is calibration. The aim of the current study was to determine the feasibility and reliability of alternative calibration methods for scenarios in which the standard visual-calibration is not possible. Fourteen participants were tested using the EyeLink 1000 Plus video-based eye tracker, and each completed the following 5-point calibration methods: 1) standard visual-target calibration, 2) described calibration where participants were provided with verbal instructions about where to direct their eyes (without vision of the screen), 3) proprioceptive calibration where participants were asked to look at their hidden finger, 4) replacement calibration, where the visual calibration was performed by 3 different people; the calibrators were temporary substitutes for the participants. Following calibration, participants performed a simple visually-guided saccade task to 16 randomly presented targets on a grid. We found that precision errors were comparable across the alternative calibration methods. In terms of accuracy, compared to the standard calibration, non-visual calibration methods (described and proprioception) led to significantly larger errors, whilst the replacement calibration method had much smaller errors. In conditions where calibration is not possible, for example when testing blind or visually impaired people who are unable to foveate the calibration targets, we suggest that using a single stand-in to perform the calibration is a simple and easy alternative calibration method, which should only cause a minimal decrease in accuracy.

Vibrotactile information improves proprioceptive reaching target localization.

When pointing to parts of our own body (e.g., the opposite index finger), the position of the target is derived from proprioceptive signals. Consistent with the principles of multisensory integration, it has been found that participants better matched the position of their index finger when they also had visual cues about its location. Unlike vision, touch may not provide an additional information about finger position in space, since fingertip tactile information theoretically remains the same irrespective of the postural configuration of the upper limb. However, since tactile and proprioceptive information are ultimately coded within the same population of posterior parietal neurons within high-level spatial representations, we nevertheless hypothesized that additional tactile information could benefit the processing of proprioceptive signals. To investigate the influence of tactile information on proprioceptive localization, we asked 19 participants to reach with the right hand towards the opposite unseen index finger (proprioceptive target). Vibrotactile stimuli were applied to the target index finger prior to movement execution. We found that participants made smaller errors and more consistent reaches following tactile stimulation. These results demonstrate that transient touch provided at the proprioceptive target improves subsequent reaching precision and accuracy. Such improvement was not observed when tactile stimulation was delivered to a distinct body part (the shoulder). This suggests a specific spatial integration of touch and proprioception at the level of high-level cortical body representations, resulting in touch improving position sense.

Adaptation of Saccadic Sequences with and without Remapping.

It is relatively easy to adapt visually-guided saccades because the visual vector and the saccade vector match. The retinal error at the saccade landing position is compared to the prediction error, based on target location and efference copy. If these errors do not match, planning processes at the level(s) of the visual and/or motor vector processing are assumed to be inaccurate and the saccadic response is adjusted. In the case of a sequence of two saccades, the final error can be attributed to the last saccade vector or to the entire saccadic displacement. Here, we asked whether and how adaptation can occur in the case of remapped saccades, such as during the classic double-step saccade paradigm, where the visual and motor vectors of the second saccade do not coincide and so the attribution of error is ambiguous. Participants performed saccades sequences to two targets briefly presented prior to first saccade onset. The second saccade target was either briefly re-illuminated (sequential visually-guided task) or not (remapping task) upon first saccade offset. To drive adaptation, the second target was presented at a displaced location (backward or forward jump condition or control-no jump) at the end of the second saccade. Pre- and post-adaptation trials were identical, without the re-appearance of the target after the second saccade. For the 1st saccade endpoints, there was no change as a function of adaptation. For the 2nd saccade, there was a similar increase in gain in the forward jump condition (52% and 61% of target jump) in the two tasks, whereas the gain decrease in the backward condition was much smaller for the remapping task than for the sequential visually-guided task (41% vs. 94%). In other words, the absolute gain change was similar between backward and forward adaptation for remapped saccades. In conclusion, we show that remapped saccades can be adapted, suggesting that the error is attributed to the visuo-motor transformation of the remapped visual vector. The mechanisms by which adaptation takes place for remapped saccades may be similar to those of forward sequential visually-guided saccades, unlike those involved in adaptation for backward sequential visually-guided saccades.