Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 14 de 14
Filtrar
Mais filtros










Intervalo de ano de publicação
1.
Future Microbiol ; 19: 449-459, 2024 03.
Artigo em Inglês | MEDLINE | ID: mdl-38497912

RESUMO

Aim: This study aimed to understand the current level of linezolid (LNZ) resistance in Streptococcus pneumoniae isolates reported over the past 10 years. Material & methods: An electronic search was conducted for the following keywords: ((Streptococcus pneumoniae [title/abstract]) OR (Pneumococcus [title/abstract]) OR (Pneumococci [title/abstract]) AND (linezolid [title/abstract]) OR (Zyvox [title/abstract])) OR (Zyvoxid [title/abstract])). Result: Out of all the studies, 80 had a cross-sectional design, while 11 followed a cohort approach. The prevalence of LNZ resistance among S. pneumoniae isolates ranged from 0% to 4.86%. Discussion: Urgent, high-powered, randomized, controlled trials with participants from endemic regions are needed to gain a comprehensive understanding of the impact on and significance of LNZ treatment to patients.


Assuntos
Antibacterianos , Streptococcus pneumoniae , Humanos , Linezolida/farmacologia , Streptococcus pneumoniae/genética , Antibacterianos/farmacologia , Prevalência , Estudos Transversais , Testes de Sensibilidade Microbiana , Farmacorresistência Bacteriana
2.
Soc Work Public Health ; 39(3): 297-312, 2024 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-38426551

RESUMO

Hygienic measures practiced at home are highly related to the occurrence of food-borne diseases during food production, storage, and handling. Contaminated food remains a major cause of several diarrheal diseases, hospitalizations, and spikes in medical expenses. In our current study, we aimed to assess the knowledge of food safety and the food safety and hygiene practices at home among the Lebanese population. A cross-sectional study was conducted through an online questionnaire including two sections. The first section included socio-demographic characteristics of participants, whereas the second section included questions related to practices and knowledge about food safety, divided into five parts; personal hygiene practices, dry and cold storage, sanitizing and cleaning and food intoxication. A total of 1101 Lebanese above 18 years participated and provided their responses to the questionnaire. Overall, the majority of participants had fair knowledge about food safety where 96.8% of the participants answered correctly about preventing microbial growth on food. 77.9% of those participants acquired their knowledge about food safety from articles, workshops, or the internet. Moreover, females, people with children and those who cook for themselves scored significantly higher than others (68.8, 70.6, and 70%, respectively). In comparison to younger participants (67.8%), older participants (50+ and 30-49) scored higher at 69.7% and 68.9%, respectively. Higher scores were obtained for questions related to storing dried foods/meat and poultry products with percentages 91.4 and 87.8%, respectively. However, lower scores were noticed on questions related to washing raw chicken before handling and storing eggs (9.7 and 12.3%, respectively). Altogether, our results revealed the need for directed food safety awareness campaigns at the national level to educate the Lebanese community about domestic food handling practices. We believe these campaigns can significantly reduce related diseases and hospitalizations.


Assuntos
Inocuidade dos Alimentos , Doenças Transmitidas por Alimentos , Feminino , Criança , Humanos , Estudos Transversais , Inocuidade dos Alimentos/métodos , Manipulação de Alimentos/métodos , Culinária/métodos , Doenças Transmitidas por Alimentos/prevenção & controle , Doenças Transmitidas por Alimentos/epidemiologia , Doenças Transmitidas por Alimentos/etiologia , Conhecimentos, Atitudes e Prática em Saúde
3.
Sports Biomech ; : 1-23, 2021 May 19.
Artigo em Inglês | MEDLINE | ID: mdl-34011240

RESUMO

Mixed martial arts (MMA) is a sport where the fighters are at high risk of brain trauma, with characteristics, such as the frequency, magnitude, and interval of head impacts influencing the risk of developing short- and long-term negative brain health outcomes. These characteristics may be influenced by weight class as they may have unique fighting styles. The purpose of this research was to compare frequency, magnitude, and interval of head impacts between lightweight and heavyweight fighters in professional MMA. Frequency, interval, event type, velocity, and location of head impacts were documented for 60 fighters from 15 Lightweight and 15 Heavyweight professional MMA fights. Head impact reconstructions of these events were performed using physical and finite element modelling methods to determine the strain in the brain tissues. The results found that LW and HW fighters sustained similar head impact frequencies and intervals. The LW fighters sustained a significantly higher frequency of very low and high magnitude impacts to the head from punches; HW a larger frequency of high category strains from elbow strikes. These brain trauma profiles reflect different fight strategies and may inform methods to manage and mitigate the long-term effects of repetitive impacts to the head.

4.
Micron ; 136: 102876, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32512409

RESUMO

BACKGROUND: In the last few decades, zebrafish (Danio rerio) were introduced as a model organism to investigate human diseases including cardiovascular and neuronal disorders. In most zebrafish investigations, cardiac function and blood flow hemodynamics need to be assessed to study the effects of the interference on the cardiovascular system. For heart function assessment, most important parameters include heart rate, cardiac output, ejection fraction, fractional area change, and fractional shortening. METHODS: A 10 s high-speed video of beating heart and flowing blood within major vessels of zebrafish that are less than 5 days post fertilization (dpf) were recorded via a stereo microscope equipped with a high speed camera. The videos were analyzed using MicroZebraLab and image J software for the assessment of cardiac function. RESULTS: Using the technique described here, we were able to simply yet effectively assess cardiac function and blood flow dynamics of normal zebrafish embryos. We believe that the practical method presented here will help cardiac researchers using the zebrafish as a model to examine cardiac function by using tools that could be available in their laboratory.


Assuntos
Circulação Sanguínea , Frequência Cardíaca/fisiologia , Hemodinâmica , Microscopia de Vídeo/métodos , Peixe-Zebra/fisiologia , Animais , Doenças Cardiovasculares , Sistema Cardiovascular , Modelos Animais de Doenças
5.
J Oral Biol Craniofac Res ; 10(2): 128-134, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32309130

RESUMO

OBJECTIVES: One of the causes of dental caries that occurs due to orthodontic treatment is the lack of antibacterial properties in orthodontic adhesive. This study was designated to investigate the effect of orthodontic resin modified by incorporating Nano Cinnamon powder on the shear bond strength of orthodontic brackets. MATERIALS AND METHODS: Heliosit Orthodontic Resin, a photo-activated light cure resin was modified by the addition of Cinnamon in the form of Nano particle powder. Twenty uniform disks were made, 5 as a control and 5 for each concentration of the 1%, 3% and 5% wt/wt Cinnamon modified resin. Their antimicrobial activity against Streptococcus Mutans was tested using the disk diffusion method. Then, the most effective concentration of the modified resin was used to bond metal orthodontic brackets to human extracted premolars. The universal testing machine was used to record the shear bond strength of the control and the modified resin. Also, the adhesive remnant index was measured. RESULTS: Disc diffusion method showed that the 3% wt/wt Cinnamon powder modified resin was more effective than 1% with a larger bacterial inhibition zone. Shear bond strengths of the control were 8.50 MPa and 7.20 MPa for the 3% Cinnamon modified resin with no significant difference between them. Also, no significant difference was recorded in the adhesive remnant index scores between the control and the modified resin groups. CONCLUSION: Findings of this study revealed that the incorporation of 3% Cinnamon Nano particles in orthodontic resin produced an antibacterial effect against Streptococcus mutans without compromising the shear bond strength. CLINICAL RELEVANCE: Incorporation of Cinnamon Nano particles in orthodontic resin may reduce caries formation around brackets during treatment course.

6.
Int Orthod ; 18(2): 246-257, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32147328

RESUMO

OBJECTIVE: This study was conducted to assess cortical bone thickness in the alveolar process of maxilla and mandible and to investigate its association with different orthodontic implant positions in Eastern Mediterranean young adults. MATERIALS AND METHODS: Computed tomography images of 50 patients aged between 18-35 years were included. Buccal, palatal and lingual cortical bone thicknesses were measured at 2, 4, 6, and 8mm from cemento-enamel junction starting from the mesial side of the second molar to the contralateral side. Pearson correlation was used to assess the association between cortical bone thickness and proposed orthodontic implant positions at all inter-radicular sites (p<0.05). RESULTS: The highest value of buccal cortical bone thickness was found mesial to the second molar in the maxilla and mandible for both genders. The value of palatal cortical bone thickness was found to be at the highest rate mesial to canine and first premolar in males and females respectively. On the other hand, the highest value of lingual cortical bone thickness was recorded to be mesial to the first molar in both genders. In addition to that, the buccal cortical bone thickness was significantly higher than palatal at the area mesial to the second molar at all four levels from the cemento-enamel junction. A significant correlation was found between cortical bone thickness and 2, 4, 6, and 8mm orthodontic implant levels in all inter-radicular sites. The values of correlation coefficients ranged from 0.280 to 0.674 in the maxillary arch and from 0.266 to 0.605 in the mandibular arch. CONCLUSIONS: From this study, we can conclude that as the position of the orthodontic implant moved more posteriorly and apically more cortical bone thickness was expected to be found in both jaws. A significant correlation was found between cortical bone thickness and the site of the orthodontic implant. Cortical bone thickness and its relationship with implant position should be taken into consideration when attempts are made to insert the orthodontic implant.


Assuntos
Osso Cortical/anatomia & histologia , Implantes Dentários , Arcada Osseodentária/anatomia & histologia , Tomografia Computadorizada por Raios X , Adolescente , Adulto , Osso Cortical/diagnóstico por imagem , Estudos Transversais , Feminino , Humanos , Arcada Osseodentária/diagnóstico por imagem , Masculino , Procedimentos de Ancoragem Ortodôntica , Adulto Jovem
7.
Braz. j. oral sci ; 19: e208189, jan.-dez. 2020. ilus
Artigo em Inglês | BBO - Odontologia, LILACS | ID: biblio-1152223

RESUMO

Aim: The aim of this study was to investigate the effect of different mouth washes and to study the effect of text message reminder on the oral health status of orthodontic patients treated with fixed appliances. Methods: This study was a clinical trial with pre-test and post-test control group design, conducted on 24 patients undergoing fixed orthodontic treatment aged 15-30 years. The patients randomly divided into two groups; one received a weekly telephone text massage reminder for the instructions of brushing and rinsing while the second group did not receive any messages. Ortho-plaque index and gingival index were used to evaluate the patient's oral hygiene status. The reading indices after brushing only were regarded as a control, then the patients were instructed to use two mouth washes, one containing sodium fluoride with cetylpyridinium chloride, the second containing chlorhexidine digluconate with cetylpyridinium chloride and Aloe Vera. Each one was used routinely for 4 weeks with the same amount and method. The washout period between the two types mouth washes was 4 weeks with a standardized toothbrush and paste. Results: Ortho-plaque index values decreased over the time between first, second and third visits. However, this index raised up at the fourth visit and again dropdown at the fifth visit. Similar results were detected for gingival index. Also, significant interaction between messages and the assessments was recorded for gingival index with a significant difference between the group of text messages and without text messages group (p<0.05). Conclusions: The results of this study showed that the combination of sodium fluoride with cetylpyridinium chloride was more potent for plaque control, while chlorhexidine digluconate with cetylpyridinium chloride and Aloe Vera combination showed a better gingival improvement. Moreover, the text messages reminder could enhance, but not replace direct oral hygiene instruction in orthodontic patients


Assuntos
Humanos , Masculino , Feminino , Cetilpiridínio , Clorexidina , Aloe , Envio de Mensagens de Texto
8.
Arterioscler Thromb Vasc Biol ; 38(12): 2806-2818, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30571172

RESUMO

Objective- Endothelial cells (ECs) sense and respond to flow-induced mechanical stress, in part, via microtubule-based projections called primary cilia. However, many critical steps during vascular morphogenesis occur independent of flow. The involvement of cilia in regulating these stages of cranial vascular morphogenesis is poorly understood because cilia have not been visualized in primary head vessels. The objective of this study was to investigate involvement of cilia in regulating the early stages of cranial vascular morphogenesis. Approach and Results- Using high-resolution imaging of the Tg(kdrl:mCherry-CAAX) y171 ;(bactin::Arl13b:GFP) zebrafish line, we showed that cilia are enriched in the earliest formed cranial vessels that assemble via vasculogenesis and in angiogenic hindbrain capillaries. Cilia were more prevalent around the boundaries of putative intravascular spaces in primary and angiogenic vessels. Loss of cardiac contractility and blood flow, because of knockdown of cardiac troponin T type 2a ( tnnt2a) expression, did not affect the distribution of cilia in primary head vasculature. In later stages of development, cilia were detected in retinal vasculature, areas of high curvature, vessel bifurcation points, and during vessel anastomosis. Loss of genes crucial for cilia biogenesis ( ift172 and ift81) induced intracerebral hemorrhages in an EC-autonomous manner. Exposure to high shear stress induced premature cilia disassembly in brain ECs and was associated with intracerebral hemorrhages. Conclusions- Our study suggests a functional role for cilia in brain ECs, which is associated with the emergence and remodeling of the primary cranial vasculature. This cilia function is flow-independent, and cilia in ECs are required for cerebral-vascular stability.


Assuntos
Artérias Cerebrais/embriologia , Veias Cerebrais/embriologia , Cílios , Células Endoteliais , Endotélio Vascular/embriologia , Neovascularização Fisiológica , Peixe-Zebra/embriologia , Animais , Animais Geneticamente Modificados , Artérias Cerebrais/metabolismo , Veias Cerebrais/metabolismo , Cílios/metabolismo , Células Endoteliais/metabolismo , Endotélio Vascular/metabolismo , Regulação da Expressão Gênica no Desenvolvimento , Proteínas de Fluorescência Verde/genética , Proteínas de Fluorescência Verde/metabolismo , Malformações Arteriovenosas Intracranianas/embriologia , Malformações Arteriovenosas Intracranianas/genética , Malformações Arteriovenosas Intracranianas/metabolismo , Proteínas Luminescentes/genética , Proteínas Luminescentes/metabolismo , Mecanotransdução Celular , Morfogênese , Troponina T/genética , Troponina T/metabolismo , Peixe-Zebra/genética , Peixe-Zebra/metabolismo , Proteínas de Peixe-Zebra/genética , Proteínas de Peixe-Zebra/metabolismo , Proteína Vermelha Fluorescente
9.
Acta Odontol Scand ; 75(6): 413-422, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28539096

RESUMO

OBJECTIVES: This study attempted to evaluate clinically and histologically the effects of olive oil (Ol) consumption on orthodontic relapse after the retention period. DESIGN: Thirty apparently healthy female albino rabbits, weight more than 1000 g each was used in this study. The animals were grouped randomly into six groups of five animals each: two control and four experimental groups. In control groups, the relapse was estimated either at zero day, or at the end of the fourth week after orthodontic retention period. In the experimental groups, the animals' groups received Ol, 7.7, or 15.4 ml/kg b.w. per day during the orthodontic retention period. The relapse was estimated either at zero day, or at the end of the fourth week after orthodontic retention period for each concentration. Modified fixed orthodontic appliances were attached to the rabbits' lower central incisors. Each rabbit received orthodontic intervention for one week, followed by six weeks retention period. At the end of the experiments, the clinical and histological investigations were conducted. Data analyses were performed at the level of p < .05 for the statistically significant difference. RESULTS: Clinically, Ol high concentration four weeks group showed a significantly lower relapse tendency than control four weeks group. Histologically, Ol low concentration zero time group showed significantly higher osteoblasts numbers than control zero time group. Olive oil low and high concentrations four weeks group showed significantly lower fibroblasts count. Moreover, Ol high concentration four weeks group revealed significantly higher bone mineralization, osteoblasts and osteocytes counts than control four weeks study group. CONCLUSIONS: Supplementation with Ol during an orthodontic retention period, especially at 15.4 ml/kg b.w. per day concentration, clinically reduced orthodontic relapse on rabbit model. Histologically, Ol increased osteoblasts and osteocytes counts and the relative amount of bone mineralization of connective tissue layer forming alveolar bone (AB) at the end of four weeks after the orthodontic retention period.


Assuntos
Processo Alveolar/efeitos dos fármacos , Azeite de Oliva/administração & dosagem , Contenções Ortodônticas , Osteoblastos/efeitos dos fármacos , Animais , Tecido Conjuntivo , Fibroblastos/efeitos dos fármacos , Modelos Animais , Aparelhos Ortodônticos , Coelhos
10.
Homo ; 64(4): 296-311, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23755965

RESUMO

The aim of this study was to evaluate the relationships of selected facial measurements with mesio-distal crown widths and dental arch dimensions in individuals with normal occlusions. A cross-sectional study was conducted on 276 subjects with Angle's Class I normal occlusions. Three-dimensional images of the face and dental casts were captured and analyzed using stereophotogrammetric systems. Significant correlations were found between the sagittal facial variables and both upper and lower dental arch dimensions and to lesser degree with the horizontal and vertical variables. The values of correlation coefficients calculated between facial and dental crown measurements ranged from .01 to .50 for upper teeth and .01 to .49 for lower teeth. The values of correlation coefficients between facial and upper dental arch dimensions ranged from .01 to .55 and those between facial and lower dental arch dimensions ranged from .01 to .60. A principal components analysis showed that the sagittal dimensions, face height, nose, labial fissure, binocular widths were positively associated with dental arch dimensions and mesio-distal crown diameters in males. On the other hand, only the sagittal variables were associated with dental dimensions in females. The results of this study confirm that positive associations exist between facial and dental arch dimensions. These relationships should be taken into consideration when attempts are made to modify dental arch size as part of orthodontic treatment. Moreover, these relationships are also relevant to prosthodontists involved with selecting tooth sizes that display optimal functional balance with the craniofacial structures.


Assuntos
Oclusão Dentária , Face/anatomia & histologia , Dente/anatomia & histologia , Adolescente , Adulto , Estudos Transversais , Arco Dental/anatomia & histologia , Feminino , Humanos , Imageamento Tridimensional , Malásia , Masculino , Adulto Jovem
11.
Aust Orthod J ; 28(1): 22-9, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22866590

RESUMO

BACKGROUND: The development of three-dimensional computer imaging has many applications in dentistry, including the analysis of dental casts. AIMS: To assess the validity and reliability of a dental stereophotogrammetric imaging system. METHODS: The sample consisted of 35 sets of dental costs. Maxillary and mandibular dental crown widths and selected dental arch dimensions were measured directly using digital calipers. Cast images were also captured by a stereophotogrammetric system and analysed using Australis software. Dahlberg's formula, paired t-tests and intra-class correlations were used to assess the random error, validity and reliability of the measurements, respectively. RESULTS: Most values demonstrated no significant difference between the direct and three-dimensional measurements with mean differences ranging from 0.05-0.21 mm. Moreover, values of intra-class correlation coefficients ranged between 0.80-0.99 for intra-examiner reliability. CONCLUSIONS: Mesiodistal crown widths and dental arch dimensions may be measured accurately with relatively small error by the specially-designed 3D system and confirms its suitability for clinical and research purposes.


Assuntos
Arco Dental/anatomia & histologia , Imageamento Tridimensional/métodos , Odontometria/métodos , Fotogrametria/instrumentação , Coroa do Dente/anatomia & histologia , Humanos , Processamento de Imagem Assistida por Computador , Imageamento Tridimensional/instrumentação , Modelos Dentários , Variações Dependentes do Observador , Reprodutibilidade dos Testes
12.
Cleft Palate Craniofac J ; 49(4): 463-71, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22236217

RESUMO

OBJECTIVE: It is clear that population-specific norms should be used when planning plastic and reconstructive surgery for selected patients. In this study, we aimed to generate nasal and labial reference values by applying a stereophotogrammetric technique. A further aim was to investigate the effect of sexual dimorphism, age-related changes, and the interrelation between nasal and labial morphology. DESIGN: Cross-sectional study. SETTING: The data were collected from different locations on the Malaysian peninsula. PARTICIPANTS: A total of 276 Asian Malays (138 males and 138 females) were included in this study, and a three-dimensional system was used for capturing data. The sample was divided into three age groups: 13 to 14, 15 to 17, and 18 to 36 years. MAIN OUTCOME MEASURE(S): Twenty-five dimensions of the nose and lips were measured and analyzed separately in males and females. RESULTS: Significant differences between males and females were identified in 11 distances, and significant effects of age were found in most of the dimensions (p < .05). Significant correlations between the nasal and labial dimensions were recorded, particularly between lateral lip height and width of the ala insertion. A principal component analysis showed interrelationships between the nasal width distances and upper lip height. CONCLUSION: This study has provided a new three-dimensional database for nose and lip morphology in Malays and demonstrated patterns of variation that can be used by surgeons to make comparisons within and between different human populations and also to develop treatment plans for their patients.


Assuntos
Povo Asiático , Lábio/anatomia & histologia , Nariz/anatomia & histologia , Fotogrametria , Adolescente , Adulto , Fatores Etários , Estudos Transversais , Feminino , Humanos , Malásia , Masculino , Fatores Sexuais
13.
Int J Pediatr Otorhinolaryngol ; 76(2): 227-34, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22136741

RESUMO

OBJECTIVE: The purpose of this study was to use three-dimensional computed tomography data and computer imaging technology to assess the skeletal components of the naso-pharyngeal area in patients with cleft lip and palate and to quantify anatomical variations. METHODS: CT scans were obtained from 29 patients of Malay origin with cleft lip and palate aged between 0 and 12 months and 12 noncleft patients in the same age group, using a GE Lightspeed Plus Scanner housed in Hospital Universiti Sains Malaysia. Measurements were obtained using the 'Persona' three-dimensional software package, developed at Australian Craniofacial Unit, Adelaide. RESULTS: The results of the present study show that there is an increased nasopharyngeal space in cleft lip and palate that may lead to compression of the nasopharyngeal structures, including the Eustachian tube. Alterations of the medial pterygoid plate and the hamulus may lead to an alteration in the origin and orientation of the tensor veli palatini muscle leading to alteration in its function. CONCLUSIONS: These anatomical variations may compromise the dilatory mechanism of the Eustachian tube, thus leading to recurrent middle ear infections in cleft children and subsequent loss of hearing.


Assuntos
Fenda Labial/diagnóstico por imagem , Fissura Palatina/diagnóstico por imagem , Imageamento Tridimensional , Nasofaringe/diagnóstico por imagem , Estudos de Casos e Controles , Fenda Labial/fisiopatologia , Fissura Palatina/fisiopatologia , Feminino , Humanos , Lactente , Recém-Nascido , Malásia , Masculino , Nasofaringe/anatomia & histologia , Valores de Referência , Tomografia Computadorizada por Raios X/métodos
14.
Cultur Divers Ethnic Minor Psychol ; 8(4): 395-403, 2002 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-12416324

RESUMO

Individualism-collectivism theory predicted that Egyptian and Canadian children's performance would differ on relevant scales of the Roberts Apperception Test for Children (RATC). The RATC was administered to 34 Egyptian and 34 Canadian children ages 6-13 years. Canadian children scored higher on autonomy and lower on receiving support from others and parental limit setting. At older ages, Egyptian children manifested less rejection, desire for help from others, and aggression. There were no cultural differences in anxiety or depression and few differences on indicator and resolution scales related to understanding the task and resolving problems. The findings validated cross-cultural use of the RATC and demonstrated that the increasingly general theory of collectivism allowed meaningful predictions about personality and clinical traits.


Assuntos
Ansiedade/etnologia , Desenvolvimento Infantil , Características Culturais , Depressão/etnologia , Teste de Apercepção Temática , Adolescente , Ansiedade/psicologia , Canadá , Criança , Comparação Transcultural , Diversidade Cultural , Depressão/psicologia , Egito , Feminino , Humanos , Masculino , Psicologia da Criança , Valores de Referência , Teste de Apercepção Temática/normas
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...