RESUMO
Different derivatives of isonicotinic acid are used widely enough as antimicrobial and antituberculous agents. However, their neurotropic and cardiotropic effects have been studied little. The paper is concerned with investigations of these types of the activity of the new derivatives of isonicotinic acid: beta-phenyl-beta-alanine, l-proline, DL-valine, beta-alanine and DL-threonine synthesized for the first time at the Institute of Fine Organic Chemistry, Academy of Sciences of Armenia.
Assuntos
Fármacos Cardiovasculares/farmacologia , Ácidos Isonicotínicos/farmacologia , Sistema Nervoso/efeitos dos fármacos , Angina Pectoris/tratamento farmacológico , Animais , Fármacos Cardiovasculares/uso terapêutico , Fármacos Cardiovasculares/toxicidade , Gatos , Avaliação Pré-Clínica de Medicamentos , Feminino , Coração/efeitos dos fármacos , Técnicas In Vitro , Ácidos Isonicotínicos/uso terapêutico , Ácidos Isonicotínicos/toxicidade , Dose Letal Mediana , Masculino , Camundongos , Ranidae , Ratos , Receptores de Superfície Celular/efeitos dos fármacos , Sono/efeitos dos fármacosRESUMO
A number of cardiotropic preparations (verapamil, obsidan, pyroxan) were studied in glycerinated fibres (GF) in the experiments on rats during five twenty four hours after ligation of coronary artery. Their ability in different degree to preserve cardiomyocyte contractile fibers from the injury of ischemic processes is revealed. Positive influence of antianginal therapy was also confirmed in the experiments with coronary artery ligation on awake animals, and in experiments on the identification of actomyosin complex components.