[Clinical morphology of chronic myeloid leukemia]. / Klinicheskaia morfologiia khronicheskogo mieloleikoza.

The morphological features of chronic myeloid leukemia at different stages of the disease were specified basing on the study of bone marrow punch biopsies of 239 patients, surgically removed spleens of 32 patients, marginal liver biopsies of 22 patients and 69 autopsies. It was found valid to distinguish two histological variants: granulocytic and granulocytic-megakaryocytic. It was shown that in the latter form of leukemia myelofibrosis, primarily of reticulin type, often tends to develop. The granulocytic-megakaryocytic variant and the diffuse myelofibrosis were found to be related to the morphological manifestations of unfavourable prognosis of chronic myeloid leukemia. The accumulation of blast cells in the central parts of bone marrow cavities, as revealed in the punch biopsies is the indication of the beginning of the blast transformation.

[Transfusion- and infusion-related iatrogenesis]. / Transfuzionno-infuzionnye iatrogenii.

Posttransfusion and postinfusion side effects and complications resulting occasionally in lethal outcomes are still available in clinical practice in spite of apparent safety and high efficiency of blood transfusions and infusions. These may be caused by the donor-recipient erythrocytic incompatibility, poor quality of the transfusion medium, disregard of contraindications to transfusion. Pathologic features of complications emerging in response to transfusion of incompatible blood or its substitutes are indicated as well as morphologic characteristics specific for posttransfusion shock and consequent acute hepatorenal insufficiency. For the substitutes there are occasional observations of the shock similar in its development to an anaphylactic one. Wide introduction of transfusion and infusion therapy into clinical practice dictates the necessity of adequate evaluation of the above therapy role in combined treatment of varying-type patients, in thanatogenesis basing on the initial patient status and previous treatment.

[Morphological characteristics of the sequelae from the parenteral administration of solutions of hydroxyethyl starch]. / Morfologicheskaia kharakteristika posledstvii parenteral'nogo vvedeniia rastvonov oksiétilirovannogo krakhmala.

Rats and rabbits were infused with solutions of hydroxyethyl starch (HES) with different physical and chemical properties. Large quantities of HES produced specific macrophage reaction in the spleen. When used in therapeutic doses (plasmaexpander) HES caused no macrophage reaction. HES proved to be non-toxic for the internal organs.

[Comparative pathomorphological study of the experimental action of carminomycin and rubomycin on the heart]. / Sravnital'noe patomorfologicheskoe issledovanie deistviia na miokard karminomitsina i rubomitsina v éksperimente.

Comparative histological investigation of the toxic effect of carminomycin and rubomycin on the myocardium was carried out on mice BDF. It was found that the level of the morphological changes in the heart muscle depended on the antibiotic dose. The cardiotoxic effect of carminomycin was less pronounced than that of rubomycin.