Whole-cell pertussis vaccine (DTwP) has no influence on allergic diseases and atopic sensitization in children.

INTRODUCTION: Vaccine opponents indicate that the infant's immune system is inadequately developed to handle multiple vaccines which may overwhelm the immune system, leading to allergic diseases. AIM: To verify the association between the vaccine antigen overload derived from DTwP and the development of atopic sensitization and allergic diseases. MATERIAL AND METHODS: Data from an earlier established birth cohort in Krakow, followed up to the 6th year of life were used. Allergic diseases such as eczema, hay fever and asthma were diagnosed by a physician and reported every half a year from the 1st to 6th year of life by the child's parent. Skin prick tests (SPT) were performed in children at 5 years of age. The data on infants' vaccination were extracted from the physician's records. The status of vaccine antigen exposure was based on different types of vaccines against pertussis (DTwP or DTaP) in a primary course. Results were determined by multiple logistic regression, adjusted to potential confounders. RESULTS: The analyzed population consisted of 234 children: 53.4% - boys and 46.6% - girls. Infants up to the age of 8 months were vaccinated with the primary course against pertussis, with DTwP - 60.7%, DTaP - 32.9% and further 6.4% with a mixed course (DTwP + DTaP). There were no significant relationships between any of vaccination groups and allergic disease and allergen sensitivity in the multiple logistic regression model with adjustment to potential confounders. CONCLUSIONS: The exposure to a large number of vaccine antigens derived from DTwP has no influence on the development of allergic diseases and atopic sensitization in children.

Epidemiology of gastroenteropancreatic neuroendocrine neoplasms in Krakow and Krakow district in 2007-2011.

INTRODUCTION: Gastroenteropancreatic neuroendocrine neoplasms (GEPNEN) are rare and heterogeneous tumours with variable biology. The aim of this study was to evaluate the epidemiology of GEPNEN in the population of Krakow and Krakow district in 2007-2011. MATERIAL AND METHODS: The Database of the Chair and Department of Endocrinology, Jagiellonian University Medical College, comprising the data on NEN cases collected from the Endocrinology Department, University Hospital in Krakow and from independent sources: surgery, pathology, and endocrinology departments located in the Krakow area, was searched for cases of GEPNEN patients living in Krakow and Krakow district, diagnosed between 2007 and 2011. Eighty-eight such patients (39 males, 49 females, median age at diagnosis 59 ± 17 years) were identified and characterised. RESULTS: The mean follow-up time was 2.67 ± 1.6 years. The most frequent primary location of GEPNEN was small intestine (20%), followed by the appendix (18%), stomach (16%), pancreas (16%), rectum (15%), and colon (15%). NENG1 predominated (64%) in the analysed group. Most well-differentiated GEPNEN (63%) were diagnosed at stage I; however, 18% of them were diagnosed at stage IV. Metastases at diagnosis were found in 31% of patients. The GEPNEN incidence rate in 2007-2011 was 2.1/100000 inhabitants/year, without significant increase during the studied period. CONCLUSIONS: GEPNEN incidence and epidemiology in the population of Krakow and Krakow district is similar to the incidence observed in most European countries. Registers are important tools to evaluate GEPNEN epidemiology. (Endokrynol Pol 2017; 68 (1): 42-46).

What mother know about vaccine preventable diseases?

INTRODUCTION AND OBJECTIVE: The improving epidemiological situation of the most of communicable diseases causes, that the real and potential risks attributable to them have been forgotten. The aim of study was to determine the mothers knowledge about vaccine preventable diseases MATERIALS AND METHODS: A survey was conducted among 177 randomly selected mothers. The interviews with mothers hospitalized after childbearing in two hospitals in Krakow and Myslenice were conducted at the end of 2014 and in 2015 RESULTS: The assessment of risk to develop an infectious diseases in unvaccinated children significantly varied among mothers. Individual respondents claimed that the risk does not exist regarding each of considered disease. The highest percentage of that kind of answers was related to poliomyelitis ­ 3.9% of mothers assessed that unvaccinated children have no risk to become ill. The similar percentage of respondents assessed a risk as remote probable regarding poliomyelitis, pertussis and hepatitis A - 16.8%, 15.2% and 16.3%, respectively. The highest risk was attributed to varicella ­ 50.6% mothers gave that answers. Mothers could not state a risk of disease developing mostly with regard to poliomyelitis, diphtheria, hepatitis A and pertussis ­ 42.7%, 38.2%, 33.7% and 33.2%, respectively. Relatively high percentage of respondents stated a mild course of that kind of diseases like varicella, mumps, rubella, infectious diarrhea and measles - from 17.4% with respect to measles to 34.3% regarding varicella. To life-threating category mothers primarily included sepsis (74.2%), meningitis and tick-borne encephalitis (each obtained 68.5% answers) CONCLUSIONS: Mothers knowledge about vaccine preventable diseases varied depending on the type of disease. The lack of awareness of the risk related to communicable diseases regarded not only those diseases which have not been occurred in Poland for many years but also those ones that still represent significant epidemiological problem. The society too often has an opinion that some diseases like varicella, mumps or rubella are the mild diseases what can conduce to easy withdrawal from those vaccinations

Opinions about vaccination among mothers who delivered newborns in two hospitals in Krakow and Myslenice

INTRODUCTION AND OBJECTIVE: Campaigns against vaccinations in Poland have been increasingly more frequently observed in recent years, that was the reason of bigger number of parents refusing a consent for their children immunization. The aim of study was to determine the sources of information which significantly influence mothers' opinions about vaccinations. MATERIALS AND METHODS: A survey was conducted among 154 randomly selected mothers hospitalized after childbearing in two hospitals in Krakow and Myslenice at the end of 2014 and in 2015. The research tool was the author's structured questionnaire interview. RESULTS: The majority of mothers regarded vaccinations as an efficient method of children protection against infectious diseases. Nevertheless, a few percent of women admitted that it is not efficient method or had no opinion about it. The mothers' confidence was higher for vaccines known for many years compared to new formulations ­ 23.7% did not trust them and 22.4% had no statement on it. The most of respondents claimed that the safety of polyvalent vaccines is lower than single formulas, and were convinced that children receive too many vaccines. About 54.6% of mothers had no opinion and 13.6% admitted that children with chronic diseases should not be vaccinated. Depending on the question content from 3.2% to 54.6% respondents had no opinion about included vaccination issues. The pediatricians and family doctors were the main and the most reliable source of information about vaccinations. The reliability of doctors was assessed higher by citizens of big city compared to women living in rural area (statistically significant). Above 50% of mothers used mass media as a source of information about vaccination but less than 8% regarded them as reliable. CONCLUSIONS: Despite the wide access to different source of information, the newborns' mothers too often had the knowledge and opinions about vaccination inconsistent with data derived from medical facts. Furthermore, significant group of mothers had no opinions about important issues with respect to vaccinations. At the beginning of infants life when parents decide of their child immunization, the reliable knowledge about that issue should be delivered by GPs because the other sources of information are assessed as much less reliable.

The effectiveness of rotavirus vaccine in preventing acute gastroenteritis during rotavirus seasons among Polish children.

INTRODUCTION: Rotavirus is the main etiological cause of intestinal infections in children. Voluntary rotavirus vaccines were included in the Polish vaccination schedule in 2007. The aim of this study was to assess the effectiveness of a completed rotavirus vaccination course in preventing acute gastroenteritis in Polish infants during their first five years of life. MATERIAL AND METHODS: This was a retrospective cohort study conducted in Lesser Poland (Malopolska Province). The sample population included a group of 303 children who received the completed rotavirus vaccination course and 303 children not vaccinated against rotavirus. The date of the child's acute gastroenteritis diagnosis and his or her vaccination history were extracted from the physicians' records. Each kind of diagnosed acute gastroenteritis during winter-spring rotavirus seasons was treated as the endpoint. The relative risk of having gastrointestinal infection was assessed using the hazard ratio from the Cox proportional hazards regression model. RESULTS: In the examined group, 96 (15.8%) children had winter-spring gastrointestinal infections. In the non-vaccinated children, the cumulative incidence of these infections in the first 5 years of life was 20.8%, whereas in the children vaccinated with Rotarix it was only 10.9%. Those who were vaccinated with Rotarix had a 44% reduction in the risk of a winter-spring acute gastroenteritis infection compared to those not vaccinated with Rotarix (p = 0.005). Birth weight less than 2500 g increased the risk of the infection twofold and also reached statistical significance (p = 0.044). CONCLUSIONS: The results showed that Rotarix is effective in preventing acute gastroenteritis in Polish children during rotavirus seasons.

Incomplete oral sanation as a risk factor for elevated leucocytosis and postoperative infection.

BACKGROUND: Patients after cardiac surgery are particularly at risk of infections. The oral cavity is a potential source of bacteria. AIM: To assess of influence of incomplete oral sanation on the probability of occurrence of infection in the postoperative period. METHODS: The study subjects (n = 240) were patients undergoing cardiac surgery, with (n = 185) and without (n = 55) complete oral sanation. Complete oral sanation - patients had treated and eradicated all potential inflammatory foci in the oral cavity. Dental treatment: conservative dental treatment (70%), endodontic treatment (30%), and surgical dental treatment (85%), depending on treatment needs. RESULTS: Patients with incomplete oral cavity sanation had more infections (7.27% vs. 1.62%, p = 0.062) in the postoperative period. The risk of infection was six times higher compared to the patients with complete sanation (p = 0.042), which correlated with higher level of leucocytosis in the early postoperative period (10.11 vs. 10.96 × 103/µL, p = 0.059). CONCLUSIONS: Incomplete oral sanation is associated with higher levels of leucocytosis and greater risk of infection in the early postoperative period.

Prenatal polycyclic aromatic hydrocarbon (PAH) exposure, antioxidant levels and behavioral development of children ages 6-9.

PURPOSE: Prenatal polycyclic aromatic hydrocarbon (PAH) exposure has been shown to increase DNA adduct levels and to affect neurodevelopment. Micronutrients may modify the adverse effect of PAH on neurodevelopment. Thus, we examined if micronutrient concentrations modified the association between PAH exposure and neurodevelopmental outcomes. METHODS: 151 children from a birth cohort who had micronutrient concentrations measured in cord blood and completed the Child Behavioral Checklist (CBCL), between the ages of 6 and 9 years, were evaluated. Prenatal airborne PAH exposure was measured by personal air monitoring. The betas and 95% CI for the associations of antioxidant concentrations and PAH exposure with each of the outcomes of CBCL raw score and dichotomized standardized T-score (based on clinical cutpoints) were estimated, respectively, by multivariable poisson and logistic models. RESULTS: Children below the median for alpha-tocopherol and gamma-tocopherol concentrations, compared to those above, were more likely to have thought problems, aggressive behavior and externalizing problems (p<0.05). Lower carotenoid concentration was associated with more thought problems (MVß=0.60, p<0.001) and externalizing problems (MVß=0.13, p<0.05) for the same contrast. No statistically significant associations were observed between retinol concentrations and neurodevelopmental symptoms. Overall, no consistent patterns were observed when we examined the interaction between antioxidants (e.g., alpha-tocopherol) and PAH in relation to CBCL symptoms (e.g., internalizing and externalizing problems, p<0.05). CONCLUSIONS: Lower alpha-tocopherol, gamma-tocopherol and carotenoid levels may adversely affect healthy neurodevelopment, even after accounting for PAH exposure. Future research to confirm these findings are warranted given the importance of identifying modifiable factors for reducing harmful PAH effects.

Gastroenteropancreatic neuroendocrine neoplasms: a 10-year experience of a single center.

INTRODUCTION: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) constitute a rare and heterogeneous group of tumors with varied biology. OBJECTIVES: The aim of this study was to establish the clinical characteristics of patients with GEP-NEN and identify factors influencing their 5-year survival. PATIENTS AND METHODS: The study included 122 patients living in Kraków or its administrative region, who were diagnosed with GEP-NEN between 2002 and 2011. RESULTS: The mean follow-up period was 4.9 ±2.8 years. The most frequent primary site of the tumor was the small intestine (n = 25; 20%), followed by pancreas (n = 23; 19%), rectum (n = 23; 19%), stomach (n = 21; 17%), appendix (n = 19; 16%), and colon (n = 11; 9%). There were 84 tumors classified as NEN G1; 31, as NEN G2; 5, as neuroendocrine carcinoma; and 1, as mixed adenoneuroendocrine carcinoma. Most well-differentiated GEP-NENs (n = 57; 57%) were diagnosed at stage I according to the American Joint Committee on Cancer / Union for International Cancer Control (AJCC/UICC) classification; 77% of NEN G1 (n = 64) were diagnosed at stage I, but the majority of NEN G2­at stage IV (n = 18; 58%). Metastases at diagnosis were found in 38 patients (34%). In 90% of the cases (n = 101), tumors were hormonally nonfunctional. The overall 5-year survival was 85%. In the univariate analysis, NEN G2 (P = 0.003), higher stage according to the AJCC/UICC classification (P <0.001), and metastases at diagnosis (P <0.001) were associated with poorer prognosis. In standardized multivariate models, higher stage (P = 0.02) and metastases at diagnosis (P = 0.02) were independent risk factors for death. CONCLUSIONS: The most important factors affecting survival of patients with GEP-NENs are tumor stage and the presence of metastases at diagnosis. The analysis of single-center data improves identification of patients with poorer prognosis requiring a more aggressive approach.

Early exposure to thimerosal-containing vaccines and children's cognitive development. A 9-year prospective birth cohort study in Poland.

UNLABELLED: The controversial topic of the early exposure to mercury is regarding ethylmercury, which is present in the thimerosal-containing vaccines (TCVs). The objective of this study was to determine the relationship between the early exposure to TCVs and cognitive development in children during the first 9 years of life. The cohort included 318 children vaccinated in an early period (neonatal and up to 6 months) against hepatitis B and diphtheria-tetanus-pertussis (DTP) using formulation with or without thimerosal. The children's development was assessed using the Fagan test (6th month of life), the Bayley Scales of Infant Development (BSID)-II (12th-36th month), the Raven test (5th, 8th year), and the Wechsler Intelligence Scale for Children (WISC-R) (6th, 7th, 9th year). Results were determined by multivariable linear and logistic regression, adjusted to potential confounders. Children exposed and not exposed to TCVs in the neonatal period had similar outcomes of cognitive-developmental tests; only the results of BSID-II at the 36th month and WISC-R at the 9th year were significantly higher for those exposed to TCVs. Developmental test results in children exposed to TCVs up to the 6th month of life also did not depend on thimerosal dose. CONCLUSION: TCV administration in early infancy did not affect children's cognitive development.

Sensitivity of passive diarrhea surveillance in infants up to the second year of life in Malopolskie voivodeship.

INTRODUCTION: In EU countries and also in Poland, the surveillance of infectious acute gastro-enteritis is a mandatory system based on cases notification (suspected and confirm) conducted by physicians in hospitals and ambulatory care. STUDY OBJECTIVE: The assessment of surveillance sensitivity on acute diarrhea in children up to 2nd year of life in Malopolskie voivodeship from 2009 to 2012. MATERIAL AND METHODS: The data about 720 infants surveyed respectively from birth up to 2nd year of life were used in this study. The information on acute diarrhea cases (outpatient and hospitalized) occurred in infants during follow-up was included in analysis. The data derived from medical records. Each case of acute diarrhea in infants detected by medical records was surveyed in local surveillance system on infectious diseases whether it was notified by physician. RESULTS: The surveillance sensitivity on acute diarrhea in infants up to 2nd year of life increased in Malopolskie voivodeship from 14.3% in 2009 to 24.3% in 2012. The sensitivity of surveillance on hospitalized cases was twofold higher compared to all kind of cases assessed inclusively. CONCLUSION: The surveillance sensitivity on acute diarrhea in infants up to 2nd year of life improved significantly in recent years but is still too low, especially with respect to outpatient cases.

Oral hygiene in population of southern Poland.

AIMS: Proper oral hygiene is an important element in the prevention of many diseases. Oral hygiene habits different depending on the place of residence, age and public awareness. The aim of the study was assessment of oral hygiene habits in a group of patients admitted for cardiac surgery. MATERIAL AND METHODS: The database has been made on the basis of anonymous questionnaires filled by all participants. The study included 643 patients admitted to the hospital for surgical treatment of acquired heart disease. We divided patients into 3 groups depending on age, place of residence and type of heart disease. RESULTS: More than 30% of patients brush their teeth once a day or less. Over 40% of all respondents do not attend for regular visits to the dentist. Most patients, who do not brush teeth or dentures were in group > 70 years old (6%) and live in the countryside. Patients in a big city perform control visit the most often (64%) and this group had the largest proportion of pa- tients who declared that the visits take place once a year or more (46%). CONCLUSIONS: Habits of proper oral hygiene among patients scheduled for cardiac surgery are at high level. 9 out of 10 patients declares daily teeth brushing. Among patients living in the country, 46% do not use regular visits and only 29% go to the dentist once a year or more often. Education campaigns about influence of the improper oral cavity hygiene should be initiated.

Stability of the mental and motor Bayley Scales of Infant Development (2nd ed.) in infants over first three years of life.

UNLABELLED: Despite the Bayley Scales of Infant Development second edition (BSID-II) are wide used both clinically and in research settings, only a few published studies have been examined their stability over time. AIM OF STUDY: The aim of this study was to examine the stability of mental and motor BSID-II scores over the first three years of life. MATERIAL AND METHODS: All children included in this study were a sample followed up in a study on the susceptibility of the fetus and child to environmental factors. The cohort recruited prenatally in Krakow Poland, included 408 children. The mental and motor scales of BSID-II were administered to infants at the end of 12th, 24th and 36th month of life. Stability of the test scores from first to second and third assessment was evaluated using the Pearson's correlation coefficient calculated for the entire group of infants, and for the each gender separately. RESULTS: The older infants obtained the better outcomes in BSID-II. The correlation between the first and second assessments for the Psychomotor Developmental Index (PDI) was r = 0.30, for the Mental Developmental Index (MDI) was r = 0.33, and between the second and third assessments the correlation for the PDI was r = 0.40, for the MDI was r = 0.59. That results suggest a low or moderate degree of relationship between the tests outcomes. Only 8,8% to 34,8% of variance in the infants later BSID-II scores could be explained by their earlier scores. The correlation between the tests scores was higher between outcomes obtained by girls than boys. CONCLUSION: The BSID-II should not be treated as a useful measure for predictive purposes of infants development.

Usefulness of maternal assessment of children development based on reported age of achieved milestones.

STUDY OBJECTIVE: The aim of the study was to examine the usefulness of maternal recall of selected developmental milestones by testing their correlations with the Bayley Scales of Infant Development (BSID-II). MATERIAL AND METHODS: Prospective cohort study. The cohort recruited prenatally, included 387 children. The BSID-II tests were carried out in each child at the end of the 12th, 24th and 36th month of life. When children were 3 years old, mothers were questioned about their child's age at attainment of 8 significant developmental milestones. RESULTS: The infants who attained developmental milestones earlier in their first years of life were more likely to achieved a better scores on the motor scale of the BSID-II. Correlation coefficients ranged from -0.117 for bladder control to -0.424 for standing without assistance and -0.586 for walking unassisted. Correlation arose when the difference between the time of achieving a particular milestone and time of managing the BSID-II was smaller. CONCLUSION: Our study demonstrated that maternal reports of developmental milestones of children under 3 years old are sufficiently reliable to be used in clinical judgment.

Measles, mumps and rubella (MMR) vaccination has no effect on cognitive development in children - the results of the Polish prospective cohort study.

OBJECTIVES: The aim of the study was to examine the hypothesis that MMR exposure has a negative influence on cognitive development in children. Furthermore, MMR was compared to single measles vaccine to determine the potential difference of these vaccines safety regarding children's cognitive development. METHODS: The prospective birth cohort study with sample consisted of 369 infants born in Krakow. Vaccination history against measles (date and the type of the vaccine) was extracted from physicians' records. Child development was assessed using the Bayley Scales of Infant Development (BSID-II) up to 3rd year of life, Raven test in 5th and 8th year and Wechsler (WISC-R) in 6th and 7th year. Data on possible confounders came from mothers' interview, medical records and analyses of lead and mercury level at birth and at the end of 5th year of life. Linear and logistic regression models adjusted for potential confounders were used to assess the association. RESULTS: No significant differences in cognitive and intelligence tests results were observed between children vaccinated with MMR and those not vaccinated up to the end of the 2nd year of life. Children vaccinated with MMR had significantly higher Mental BSID-II Index (MDI) in the 36th month than those vaccinated with single measles vaccine (103.8±10.3 vs. 97.2±11.2, p=0.004). Neither results of Raven test nor WISC-R were significantly different between groups of children vaccinated with MMR and with single measles vaccine. After standardization to child's gender, maternal education, family economical status, maternal IQ, birth order and passive smoking all developmental tests were statistically insignificant. CONCLUSION: The results suggest that there is no relationship between MMR exposure and children's cognitive development. Furthermore, the safety of triple MMR is the same as the single measles vaccine with respect to cognitive development.

[Factors determining students' knowledge on wild mushrooms]. / Czynniki warunkujace wiedze studentów o grzybach dziko rosnacych.

A survey was conducted among students of university schools in Nowy Sacz, Biala Podlaska and Zamosc to determine the guidelines of mushroom poisoning prevention. The study included 580 people. The dependence of knowledge about mushrooms from the place of origin of students, frequency of participation in mushrooming, preferred sources of information about mushrooms, major of study and self-competence in discsriminating of mushrooms was determined. Mushrooms gathered nearly 80% of respondents. Residents of large cities more often that those living in villages and small towns have difficulites in distinguishing the edible and poisonous mushrooms. People often participating in mushrooming retain proper habits during the harvesting and processing of mushrooms. Irrational ways of distinguishing edible mushrooms from poisonous are often rejected by inexperienced people than by frequently gathering mushrooms. Nearly 20% of respondents, regardless of their own experience and self-assessment of their competence in discriminating mushrooms belive that after culinary preparation can by safely consume even deadly poisonous species. The primary source of knowledge on mushrooms for the majority of responents are parents. There was no correlation between the preferred source of information about mushrooms and belief in the myths about them. Knowledge on the mushrooms of medical students (nursing, emergency medical service) is not greater than students other courses.

Neonatal exposure to Thimerosal from vaccines and child development in the first 3 years of life.

BACKGROUND: Despite the common use of Thimerosal as a preservative in childhood vaccines since the 1930s, there are not many studies on ethylmercury toxicokinetics and toxicodynamics in infants. The knowledge of ethylmercury's potential adverse effects is derived mostly from parallel methylmercury research or from animal and theoretical models. AIM OF THE STUDY: This study was designed to examine the relationship between neonatal exposure to Thimerosal-containing vaccine (TCV) and child development. MATERIAL AND METHODS: The study sample consisted of 196 infants born between January 2001 and March 2003 to mothers attending ambulatory prenatal clinics in the first and second trimesters of pregnancy in Krakow. Vaccination history (date and the type of the vaccine) was extracted from physicians' records. Child development was assessed using the Bayley Scales of Infant Development (BSID-II) measured in one-year intervals over 3years. General Linear Model (GLM) and Generalized Estimating Equation (GEE) models adjusted for potential confounders were used to assess the association. RESULTS: An adverse effect of neonatal TCV exposure was observed for the psychomotor development index (PDI) only in the 12th and 24th months of life (ß=-6.44, p<0.001 and ß=-5.89, p<0.001). No significant effect of neonatal TCV exposure was found in the 36th month. The overall deficit in the PDI attributable to neonatal TCV exposure measured over the course of the three-year follow-up (GEE) was significantly higher in TCV group (ß=-4.42, p=0.001). MDI scores did not show the adverse association with neonatal TCV exposure.

[Lack of association between thimerosal-containing vaccines and autism]. / Brak zwiazku miedzy ekspozycja na szczepionki zawierajace tiomersal i rozwojem autyzmu u dzieci.

In Poland, administered childhood vaccines still contain thimerosal as a preservative. Despite the access to mercury free formulas, the most of children are still vaccinated by thimerosal-containing vaccines (TCV) owing to economical reasons. That circumstances caused the rising discussion on potential harmful influence of TCVs on children health. The objective of this analysis was to determine an association of TCVs exposure with the risk of autism. Study population included 96 cases diagnosed with childhood or atypical autism and 192 controls matched individually by year of birth, gender, and physician's practice. Data on autism diagnose and vaccination history were from GPs. Data on the other possible autism risk factors were collected from mothers. Conditional logistic regression was used to assess the risk of autism due to TCVs exposure. No significant association was found between TCVs exposure and autism. After adjusting to potential confounders, odds ratios of the risk of autism developing for infants vaccinated with TCVs were 1.52 (95% CI: 0.29-11.11) for doses 12.5-87.5 microg, 2.78 (95% CI: 0.29-11.11) for 100-137.5 microg and 1.97 (95% CI: 0.37-18.95) for these exposed > or = 150 microg. Our study revealed no evidence of an association between TCVs and autism.

[The parents opinion on the risk factors of autism in their children]. / Opinie rodziców na temat czynników, które mogly spowodowac rozwój autyzmu u ich dzieci.

The mothers' opinions about the reasons of their children autism have been collected during case-control study on risk factors of that disease. The relationship between different opinions and mothers' characteristics have been analyzed. The categories of autism reasons mentioned by mothers have been related to the current knowledge about the risk factors of disease.

Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children's intelligence at 5 years of age in a prospective cohort study in Poland.

BACKGROUND: In this prospective cohort study of Caucasian mothers and children in Krakow, Poland, we evaluated the role of prenatal exposure to urban air pollutants in the pathogenesis of neurobehavioral disorders. OBJECTIVES: The objective of this study was to investigate the relationship between prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child intelligence at 5 years of age, controlling for potential confounders suspected to play a role in neurodevelopment. METHODS: A cohort of pregnant, healthy, nonsmoking women was enrolled in Krakow, Poland, between 2001 and 2006. During pregnancy, participants were invited to complete a questionnaire and undergo 48-hr personal air monitoring to estimate their babies' exposure, and to provide a blood sample and/or a cord blood sample at the time of delivery. Two hundred fourteen children were followed through 5 years of age, when their nonverbal reasoning ability was assessed using the Raven Coloured Progressive Matrices (RCPM). RESULTS: We found that higher (above the median of 17.96 ng/m3) prenatal exposure to airborne PAHs (range, 1.8-272.2 ng/m3) was associated with decreased RCPM scores at 5 years of age, after adjusting for potential confounding variables (n = 214). Further adjusting for maternal intelligence, lead, or dietary PAHs did not alter this association. The reduction in RCPM score associated with high airborne PAH exposure corresponded to an estimated average decrease of 3.8 IQ points. CONCLUSIONS: These results suggest that prenatal exposure to airborne PAHs adversely affects children's cognitive development by 5 years of age, with potential implications for school performance. They are consistent with a recent finding in a parallel cohort in New York City.