Multi-scale neural decoding and analysis.

Objective. Complex spatiotemporal neural activity encodes rich information related to behavior and cognition. Conventional research has focused on neural activity acquired using one of many different measurement modalities, each of which provides useful but incomplete assessment of the neural code. Multi-modal techniques can overcome tradeoffs in the spatial and temporal resolution of a single modality to reveal deeper and more comprehensive understanding of system-level neural mechanisms. Uncovering multi-scale dynamics is essential for a mechanistic understanding of brain function and for harnessing neuroscientific insights to develop more effective clinical treatment.Approach. We discuss conventional methodologies used for characterizing neural activity at different scales and review contemporary examples of how these approaches have been combined. Then we present our case for integrating activity across multiple scales to benefit from the combined strengths of each approach and elucidate a more holistic understanding of neural processes.Main results. We examine various combinations of neural activity at different scales and analytical techniques that can be used to integrate or illuminate information across scales, as well the technologies that enable such exciting studies. We conclude with challenges facing future multi-scale studies, and a discussion of the power and potential of these approaches.Significance. This roadmap will lead the readers toward a broad range of multi-scale neural decoding techniques and their benefits over single-modality analyses. This Review article highlights the importance of multi-scale analyses for systematically interrogating complex spatiotemporal mechanisms underlying cognition and behavior.

Towards a common template for neural reinforcement of finger individuation.

The inability to individuate finger movements is a common impairment following stroke. Conventional physical therapy ignores underlying neural changes with recovery, leaving it unclear why sensorimotor function often remains impaired. Functional MRI neurofeedback can monitor neural activity and reinforce it towards a healthy template to restore function. However, identifying an individualized training template may not be possible depending on the severity of impairment. In this study, we investigated the use of functional alignment of brain data across healthy participants to create an idealized neural template to be used as a training target for new participants. We employed multi-voxel pattern analyses to assess the prediction accuracy and robustness to missing data of pre-trained functional templates corresponding to individual finger presses. We found a significant improvement in classification accuracy (p < 0.001) of individual finger presses when group data was aligned based on function (88%) rather than anatomy (46%). Importantly, we found no significant drop in performance when aligning a new participant to a pre-established template as compared to including this new participant in the creation of a new template. These results indicate that functionally aligned templates could provide an effective surrogate training target for patients following neurological injury.

A Usability Study of Low-cost Wireless Brain-Computer Interface for Cursor Control Using Online Linear Model.

Computer cursor control using electroencephalogram (EEG) signals is a common and well-studied brain-computer interface (BCI). The emphasis of the literature has been primarily on evaluation of the objective measures of assistive BCIs such as accuracy of the neural decoder whereas the subjective measures such as user's satisfaction play an essential role for the overall success of a BCI. As far as we know, the BCI literature lacks a comprehensive evaluation of the usability of the mind-controlled computer cursor in terms of decoder efficiency (accuracy), user experience, and relevant confounding variables concerning the platform for the public use. To fill this gap, we conducted a two-dimensional EEG-based cursor control experiment among 28 healthy participants. The computer cursor velocity was controlled by the imagery of hand movement using a paradigm presented in the literature named imagined body kinematics (IBK) with a low-cost wireless EEG headset. We evaluated the usability of the platform for different objective and subjective measures while we investigated the extent to which the training phase may influence the ultimate BCI outcome. We conducted pre- and post- BCI experiment interview questionnaires to evaluate the usability. Analyzing the questionnaires and the testing phase outcome shows a positive correlation between the individuals' ability of visualization and their level of mental controllability of the cursor. Despite individual differences, analyzing training data shows the significance of electrooculogram (EOG) on the predictability of the linear model. The results of this work may provide useful insights towards designing a personalized user-centered assistive BCI.

Optimizing Prediction Model for a Noninvasive Brain-Computer Interface Platform Using Channel Selection, Classification, and Regression.

A brain-computer interface (BCI) platform can be utilized by a user to control an external device without making any overt movements. An EEG-based computer cursor control task is commonly used as a testbed for BCI applications. While traditional computer cursor control schemes are based on sensorimotor rhythm, a new scheme has recently been developed using imagined body kinematics (IBK) to achieve natural cursor movement in a shorter time of training. This article attempts to explore optimal decoding algorithms for an IBK paradigm using EEG signals with application to neural cursor control. The study is based on an offline analysis of 32 healthy subjects' training data. Various machine learning techniques were implemented to predict the kinematics of the computer cursor using EEG signals during the training tasks. Our results showed that a linear regression least squares model yielded the highest goodness-of-fit scores in the cursor kinematics model (70% in horizontal prediction and 40% in vertical prediction using a Theil-Sen regressor). Additionally, the contribution of each EEG channel on the predictability of cursor kinematics was examined for horizontal and vertical directions, separately. A directional classifier was also proposed to classify horizontal versus vertical cursor kinematics using EEG signals. By incorporating features extracted from specific frequency bands, we achieved 80% classification accuracy in differentiating horizontal and vertical cursor movements. The findings of the current study could facilitate a pathway to designing an optimized online neural cursor control.