Experimenting With the New Frontier: Artificial Intelligence-Powered Chat Bots in Hand Surgery.

Background: Increased utilization of artificial intelligence (AI)-driven search and large language models by the lay and medical community requires us to evaluate the accuracy of AI responses to common hand surgery questions. We hypothesized that the answers to most hand surgery questions posed to an AI large language model would be correct. Methods: Using the topics covered in Green's Operative Hand Surgery 8th Edition as a guide, 56 hand surgery questions were compiled and posed to ChatGPT (OpenAI, San Francisco, CA). Two attending hand surgeons then independently reviewed ChatGPT's answers for response accuracy, completeness, and usefulness. A Cohen's kappa analysis was performed to assess interrater agreement. Results: An average of 45 of the 56 questions posed to ChatGPT were deemed correct (80%), 39 responses were deemed useful (70%), and 32 responses were deemed complete (57%) by the reviewers. Kappa analysis demonstrated "fair to moderate" agreement between the two raters. Reviewers disagreed on 11 questions regarding correctness, 16 questions regarding usefulness, and 19 questions regarding completeness. Conclusions: Large language models have the potential to both positively and negatively impact patient perceptions and guide referral patterns based on the accuracy, completeness, and usefulness of their responses. While most responses fit these criteria, more precise responses are needed to ensure patient safety and avoid misinformation. Individual hand surgeons and surgical societies must understand these technologies and interface with the companies developing them to provide our patients with the best possible care.

Presentation and Treatment of a Patient With Jacobs Syndrome and Metopic Craniosynostosis.

Jacobs syndrome is a rare trisomy (47, XYY) found in ~1 in 1000 male children associated with infertility, autism spectrum disorders, macrocephaly, hypertelorism, tall stature, and macroorchidism. Diagnosis is often delayed due to relatively subtle phenotypic changes. Craniosynostosis, a fusion of the cranial sutures, has been described in ~1 in 2000 live births, of which 25% are related to a diagnosed syndrome with the most common being Apert and Crouzon. Craniosynostosis does not have a known association with Jacobs syndrome and no prior cases have been reported. This case report seeks to describe the presentation and treatment of a patient with Jacobs syndrome and metopic craniosynostosis.

Reliability of spectral-temporal ripple tests in children.

Spectral-temporal ripple tests in both adaptive and non-adaptive versions have been proposed for use in the audiology clinic. Though these methods have been found to yield repeatable results and to be correlated with each other in adults, similar information about test performance in children is lacking. In this preliminary study, children ages 6-12 years completed two repetitions of the adaptive spectral-temporally modulated ripple test (SMRT) and non-adaptive SMRT Lite for computeRless Measurement (SLRM) test. The first and second repetitions of the SLRM were correlated. Though mean performance on the SMRT was significantly correlated with the SLRM, the first and second repetitions of the SMRT were not significantly correlated.

Influence of aided audibility on speech recognition performance with frequency composition for children and adults.

OBJECTIVE: The primary purpose of this project was to evaluate the influence of speech audibility on speech recognition with frequency composition, a frequency-lowering algorithm used in hearing aids. DESIGN: Participants were tested to determine word and sentence recognition thresholds in background noise, with and without frequency composition. The audibility of speech was quantified using the speech intelligibility index (SII). STUDY SAMPLE: Participants included 17 children (ages 6-16) and 21 adults (ages 19 to 72) with bilateral mild-to-severe sensorineural hearing loss. RESULTS: Word and sentence recognition thresholds did not change significantly with frequency composition. Participants with better aided speech audibility had better speech recognition in noise, regardless of processing condition, than those with poorer aided audibility. For the child participants, changes in the word recognition threshold between processing conditions were predictable from aided speech audibility. However, this relationship depended strongly on one participant with a low SII and otherwise, changes in speech recognition between frequency composition off and on were not predicable from aided speech audibility. CONCLUSION: While these results suggest that children who have a low-aided SII may benefit from frequency composition, further data are needed to generalise these findings to a greater number of participants and variety of stimuli.

Effect of level on spectral-ripple detection threshold for listeners with normal hearing and hearing loss.

This study investigated the effect of presentation level on spectral-ripple detection for listeners with and without sensorineural hearing loss (SNHL). Participants were 25 listeners with normal hearing and 25 listeners with SNHL. Spectral-ripple detection thresholds (SRDTs) were estimated at three spectral densities (0.5, 2, and 4 ripples per octave, RPO) and three to four sensation levels (SLs) (10, 20, 40, and, when possible, 60 dB SL). Each participant was also tested at 90 dB sound pressure level (SPL). Results indicate that level affected SRDTs. However, the effect of level depended on ripple density and hearing status. For all listeners and all RPO conditions, SRDTs improved from 10 to 40 dB SL. In the 2- and 4-RPO conditions, SRDTs became poorer from the 40 dB SL to the 90 dB SPL condition. The results suggest that audibility likely controls spectral-ripple detection at low SLs for all ripple densities, whereas spectral resolution likely controls spectral-ripple detection at high SLs and ripple densities. For optimal ripple detection across all listeners, clinicians and researchers should use a SL of 40 dB SL. To avoid absolute-level confounds, a presentation level of 80 dB SPL can also be used.

Cognitive Abilities Contribute to Spectro-Temporal Discrimination in Children Who Are Hard of Hearing.

OBJECTIVES: Spectral ripple discrimination tasks have received considerable interest as potential clinical tools for use with adults and children with hearing loss. Previous results have indicated that performance on ripple tasks is affected by differences in aided audibility [quantified using the Speech Intelligibility Index, or Speech Intelligibility Index (SII)] in children who wear hearing aids and that ripple thresholds tend to improve over time in children with and without hearing loss. Although ripple task performance is thought to depend less on language skills than common speech perception tasks, the extent to which spectral ripple discrimination might depend on other general cognitive abilities such as nonverbal intelligence and working memory is unclear. This is an important consideration for children because age-related changes in ripple test results could be due to developing cognitive ability and could obscure the effect of any changes in unaided or aided hearing over time. The purpose of this study was to establish the relationship between spectral ripple discrimination in a group of children who use hearing aids and general cognitive abilities such as nonverbal intelligence, visual and auditory working memory, and executive function. It was hypothesized that, after controlling for listener age, general cognitive ability would be associated with spectral ripple thresholds and performance on both auditory and visual cognitive tasks would be associated with spectral ripple thresholds. DESIGN: Children who were full-time users of hearing aids for at least 1 year (n = 24, ages 6 to 13 years) participated in this study. Children completed a spectro-temporal modulated ripple discrimination task in the sound field using their personal hearing aids. Threshold was determined from the average of two repetitions of the task. Participants completed standard measurements of executive function, nonverbal intelligence, and visual and verbal working memory. Real ear verification measures were completed for each child with their personal hearing aids to determine aided SII. RESULTS: Consistent with past findings, spectro-temporal ripple thresholds improved with greater listener age. Surprisingly, aided SII was not significantly correlated with spectro-temporal ripple thresholds potentially because this particular group of listeners had overall better hearing and greater aided SII than participants in previous studies. Partial correlations controlling for listener age revealed that greater nonverbal intelligence and visual working memory were associated with better spectro-temporal ripple discrimination thresholds. Verbal working memory, executive function, and language ability were not significantly correlated with spectro-temporal ripple discrimination thresholds. CONCLUSIONS: These results indicate that greater general cognitive abilities are associated with better spectro-temporal ripple discrimination ability, independent of children's age or aided SII. It is possible that these relationships reflect the cognitive demands of the psychophysical task rather than a direct relationship of cognitive ability to spectro-temporal processing in the auditory system. Further work is needed to determine the relationships of cognitive abilities to ripple discrimination in other populations, such as children with cochlear implants or with a wider range of aided SII.

Listener Performance with a Novel Hearing Aid Frequency Lowering Technique.

BACKGROUND: Sloping hearing loss imposes limits on audibility for high-frequency sounds in many hearing aid users. Signal processing algorithms that shift high-frequency sounds to lower frequencies have been introduced in hearing aids to address this challenge by improving audibility of high-frequency sounds. PURPOSE: This study examined speech perception performance, listening effort, and subjective sound quality ratings with conventional hearing aid processing and a new frequency-lowering signal processing strategy called frequency composition (FC) in adults and children. RESEARCH DESIGN: Participants wore the study hearing aids in two signal processing conditions (conventional processing versus FC) at an initial laboratory visit and subsequently at home during two approximately six-week long trials, with the order of conditions counterbalanced across individuals in a double-blind paradigm. STUDY SAMPLE: Children (N = 12, 7 females, mean age in years = 12.0, SD = 3.0) and adults (N = 12, 6 females, mean age in years = 56.2, SD = 17.6) with bilateral sensorineural hearing loss who were full-time hearing aid users. DATA COLLECTION AND ANALYSES: Individual performance with each type of processing was assessed using speech perception tasks, a measure of listening effort, and subjective sound quality surveys at an initial visit. At the conclusion of each subsequent at-home trial, participants were retested in the laboratory. Linear mixed effects analyses were completed for each outcome measure with signal processing condition, age group, visit (prehome versus posthome trial), and measures of aided audibility as predictors. RESULTS: Overall, there were few significant differences in speech perception, listening effort, or subjective sound quality between FC and conventional processing, effects of listener age, or longitudinal changes in performance. Listeners preferred FC to conventional processing on one of six subjective sound quality metrics. Better speech perception performance was consistently related to higher aided audibility. CONCLUSIONS: These results indicate that when high-frequency speech sounds are made audible with conventional processing, speech recognition ability and listening effort are similar between conventional processing and FC. Despite the lack of benefit to speech perception, some listeners still preferred FC, suggesting that qualitative measures should be considered when evaluating candidacy for this signal processing strategy.

Spectro-temporal modulation detection in children.

Children's performance on psychophysical tasks improves with age. The relationship of spectro-temporal modulation detection to age, particularly in children who are hard of hearing, is not well-established. In this study, children with normal hearing (N = 22) and with sensorineural hearing loss (N = 15) completed measures of spectro-temporal modulation detection. Measures of aided audibility were completed in the children who are hard of hearing. Pearson product-moment correlations were completed with listener age and aided audibility as parameters. Spectro-temporal modulation detection performance increased with listener age and with greater aided audibility.

Do "optimal" conditions improve distortion product otoacoustic emission test performance?

OBJECTIVES: To determine whether an "optimal" distortion product otoacoustic emission (DPOAE) protocol that (1) used optimal stimulus levels and primary-frequency ratios for each f2, (2) simultaneously measured 2f2 - f1 and 2f1 - f2 distortion products, (3) controlled source contribution, (4) implemented improved calibration techniques, (5) accounted for the influence of middle ear reflectance, and (6) applied multivariate analyses to DPOAE data results in improved accuracy in differentiating between normal-hearing and hearing-impaired ears, compared with a standard clinical protocol. DESIGN: Data were collected for f2 frequencies ranging from 0.75 to 8 kHz in 28 normal-hearing and 78 hearing-impaired subjects. The protocol included a control condition incorporating standard stimulus levels and primary-frequency ratios calibrated with a standard SPL method and three experimental conditions using optimized stimuli calibrated with an alternative forward pressure level method. The experimental conditions differed with respect to the level of the reflection-source suppressor tone and included conditions referred to as the null suppressor (i.e., no suppressor tone presented), low-level suppressor (i.e., suppressor tone presented at 58 dB SPL), and high-level suppressor (i.e., suppressor tone presented at 68 dB SPL) conditions. The area under receiver operating characteristic (A(ROC)) curves and sensitivities for fixed specificities (and vice versa) were estimated to evaluate test performance in each condition. RESULTS: A(ROC) analyses indicated (1) improved test performance in all conditions using multivariate analyses, (2) improved performance in the null suppressor and low suppressor experimental conditions compared with the control condition, and (3) poorer performance below 4 kHz with the high-level suppressor. As expected from A(ROC), sensitivities for fixed specificities and specificities for fixed sensitivities were highest for the null suppressor and low suppressor conditions and lowest for standard clinical procedures. The influence of 2f2 - f1 and reflectance on test performance were negligible. CONCLUSIONS: Predictions of auditory status based on DPOAE measurements in clinical protocols may be improved by the inclusion of (1) optimized stimuli, (2) alternative calibration techniques, (3) low-level suppressors, and (4) multivariate analyses.