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1.
Diagnostics (Basel) ; 12(8)2022 Jul 28.
Artigo em Inglês | MEDLINE | ID: mdl-36010170

RESUMO

Paragangliomas are rare, non-epithelial neuroendocrine neoplasms originating in paraganglia, for instance the adrenal medulla, or at extra-adrenal locations. The aim of this study was to review the literature regarding abdominal extra-adrenal paragangliomas diagnosed pre-operatively with fine-needle biopsy (FNA and/or FNB). The PubMed database was searched to identify such cases, using a specific algorithm and inclusion/exclusion criteria. An unpublished case from our practice was also added to the rest of the data, resulting in a total of 36 cases for analysis. Overall, 24 (67%) lesions were found in females, whereas 12 (33%) in males. Most (21/36; 58.33%) were identified around and/or within the pancreatic parenchyma. FNA and/or FNB reached or suggested a paraganglioma diagnosis in 17/36 cases (47.22%). Of the preoperative misdiagnoses, the most common was an epithelial neuroendocrine tumor (NET). Regarding follow-up, most patients were alive with no reported recurrence; however, 5/36 patients exhibited a recurrence or a widespread disease, whereas one patient died 48 months following her diagnosis. In two patients, transient hypertension was reported during the EUS-FNA procedure. In conclusion, this study showed that the preoperative diagnosis of these lesions is feasible and, while diagnostic pitfalls exist, they could significantly be avoided with the application of immunochemistry.

2.
Cureus ; 13(1): e12853, 2021 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-33628702

RESUMO

Primary mediastinal neuroendocrine tumor (PMNET) is an extremely rare clinical entity and few cases have been described in the literature. Here, we report a histologically confirmed rare PMNET case of a 66-year-old male patient with a mass detected in the anterior upper mediastinum by chest high-resolution computed tomography (HRCT). Early detection and surgical intervention of this neoplasm are critical for long term survival, though the tumor is associated with a dismal outcome.

3.
Cureus ; 12(11): e11792, 2020 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-33409038

RESUMO

Primary gastric malignant melanoma (PGMM) is an extremely rare clinical entity, and few cases have been described in the literature. Here, we report a histologically confirmed PGMM case of a 74-year-old man with a mass in the stomach found by gastroscopy. The patient had no history of melanoma. This rare disease may be misdiagnosed for another gastric malignant tumor type when there is no known primary lesion. Early detection and surgical intervention are critical for long term survival or cure, though the tumor is often advanced at the time of diagnosis and is associated with a dismal outcome.

4.
Diagn Cytopathol ; 45(6): 565-568, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28261927

RESUMO

Paragangliomas are rare neoplasms that arise from neural crest cells of the autonomous system. Herein, we present a case of a 37-year-old patient with a history of retroperitoneal paraganglioma and tuberculous infection presenting with a paraganglioma of the neck that was initially misdiagnosed as metastatic tumor originating from the lungs. Cytological features from fine needle aspiration and immunocytochemistry pointed to the right diagnosis. However, distinguishing between primary and metastatic site of a paraganglioma can be very challenging due to the overlapping features of these entities. Furthermore, this case underlines the value of a detailed medical history in the era of modern diagnostic modalities. Diagn. Cytopathol. 2017;45:565-568. © 2017 Wiley Periodicals, Inc.


Assuntos
Neoplasias de Cabeça e Pescoço/patologia , Neoplasias Pulmonares/patologia , Paraganglioma Extrassuprarrenal/patologia , Adulto , Biópsia por Agulha Fina , Diagnóstico Diferencial , Feminino , Humanos , Metástase Neoplásica
5.
Pediatr Surg Int ; 33(6): 727-730, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28353086

RESUMO

Intraductal papilloma (IP) constitutes a rare benign neoplasm among male population with only few reports on childhood patients. Herein, we describe an 11-year-old IP male patient who presented with spontaneous nipple discharge of his right breast.


Assuntos
Neoplasias da Mama Masculina/diagnóstico , Mama/patologia , Papiloma Intraductal/diagnóstico , Mama/diagnóstico por imagem , Mama/cirurgia , Neoplasias da Mama Masculina/cirurgia , Hemorragia , Humanos , Masculino , Pessoa de Meia-Idade , Derrame Papilar , Papiloma Intraductal/cirurgia
6.
J Cytol ; 32(4): 223-9, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26811568

RESUMO

BACKGROUND: Human papillomavirus (HPV) is known to be involved in the carcinogenesis of squamous cells in uterine cervix cancer, mostly by binding and inactivating the p53 and pRb tumor suppressor genes. Lately, evidence has emerged suggesting that HPV oncoproteins may interact with proteins involved in cellular apoptosis as well. AIM: This study aimed to investigate the expression of proapoptotic proteins Bax and Bak in women with low-risk and high-risk HPV types as opposed to HPV-negative women, and in women with normal pap smear compared to women with abnormal Papanicolau test (Pap) smear. MATERIALS AND METHODS: A total of 120 liquid-based cervical samples were subtyped for HPV types with microarray hybridization and then stained and evaluated immunocytochemically for Bax and Bak expression. Statistical analysis was performed on the Bax and Bak scores (percentage of positive cells × staining intensity), the overall percentage of positive cells, and the most prevalent staining intensity group found in each sample. RESULTS: A weak association between negative Bax staining and cytologically normal Pap smears was discovered, whereas cytologically abnormal samples tended to stain weakly or moderately positive. No other statistically significant difference was found in the other analyzed parameters. CONCLUSION: Cytologically normal pap smears seem to have a slight tendency to stain negative for Bax as opposed to cytologically abnormal pap smears. Although the association is weak, it is an indication that there might be a connection between the expression of Bax and the development of cervical intraepithelial dysplasia, which warrants further investigation in larger-scale studies.

7.
Diagn Cytopathol ; 41(3): 206-11, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-21965020

RESUMO

Ameloblastoma is an odontogenic tumor with aggressive biological behavior, high recurrence rate, and a complex microscopic appearance with many different histologic patterns. Primary ameloblastoma is also described in extragnathic locations. Because of its wide morphologic spectrum, which is mirrored also in cytologic smears, a thorough study of distinctive features is required to reach a reliable diagnosis. Twelve cases of ameloblastoma were examined both cytologically and histologically. The patients were seven women and five men 24-85 years old, mean age being 64 years. Eleven cases were primary tumors of the mandible and maxilla, and one case was a lung tumor metastatic from the tibia. The epithelial element in the cytologic smears of the various cases was morphologically diverse. The basaloid pattern and minimal nuclear atypia were rather constant findings, and the most helpful features toward reaching a cytological diagnosis. However in most cases, careful consideration of the clinical, radiological, cytological, and occasionally immunocytochemical data was required to rule out other entities with similar cytological findings. In some cases, the final diagnosis was only possible by histologic examination. Due to their variable microscopic morphology, ameloblastomas are quite often misdiagnosed for other entities, both benign and malignant. Nevertheless, when one is aware of their distinctive features, an accurate diagnosis can be made by fine-needle aspiration cytology, in conjunction with clinical and radiological findings. Both the preoperative surgical planning and the postoperative follow-up of the patients benefit significantly from this method.


Assuntos
Ameloblastoma/patologia , Neoplasias Ósseas/patologia , Neoplasias Pulmonares/secundário , Neoplasias Mandibulares/patologia , Neoplasias Maxilares/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Ameloblastoma/diagnóstico por imagem , Ameloblastoma/cirurgia , Biópsia por Agulha Fina , Núcleo Celular/patologia , Citoplasma/patologia , Feminino , Humanos , Masculino , Neoplasias Mandibulares/diagnóstico por imagem , Neoplasias Mandibulares/cirurgia , Neoplasias Maxilares/diagnóstico por imagem , Neoplasias Maxilares/cirurgia , Pessoa de Meia-Idade , Radiografia , Tíbia/patologia , Adulto Jovem
8.
Diagn Cytopathol ; 40(3): 239-44, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20890998

RESUMO

Proliferative myositis (PM) and myositis ossificans (MO) are two uncommon, benign pseudosarcomatous lesions of soft tissue. Despite their benign nature, they are often misdiagnosed for malignant soft tissue tumors because of their alarming clinical presentation. Fine needle aspiration cytology (FNAC) is a quick and simple method that can accurately diagnose such lesions, provided that the cytopathologist is adequately familiar with the cytomorphological features of these lesions as opposed to the features of sarcomas. In this report, we present three cases of PM and one case of MO diagnosed by FNAC. Their cytomorphological features are described, and related literature is reviewed.


Assuntos
Miosite Ossificante/patologia , Miosite/patologia , Adulto , Biópsia por Agulha Fina , Citodiagnóstico , Técnicas Citológicas , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sarcoma/patologia , Neoplasias de Tecidos Moles/patologia
9.
J Oral Sci ; 53(2): 249-52, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21712632

RESUMO

Ectopic thyroid gland is rarely seen in the submandibular region, thereby posing difficult diagnostic and management problems. Two Caucasian women presented with painful swelling in the submandibular region, which increased in size considerably during the preceding months. Ultrasound-guided fine needle biopsy (Ug-FNB) revealed ectopic thyroid tissue. In conclusion, ectopic thyroid gland with or without pathology should be included in the differential diagnosis of submandibular swelling and Ug-FNB should be one of the first diagnostic tools utilized for this rare clinical entity.


Assuntos
Biópsia por Agulha Fina/métodos , Coristoma/patologia , Doenças da Glândula Submandibular/patologia , Glândula Tireoide/patologia , Ultrassonografia de Intervenção/métodos , Adulto , Coristoma/diagnóstico por imagem , Diagnóstico Diferencial , Feminino , Humanos , Doenças da Glândula Submandibular/diagnóstico por imagem , Glândula Tireoide/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Ultrassonografia Doppler em Cores
10.
Acta Cytol ; 54(5 Suppl): 898-902, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21053565

RESUMO

UNLABELLED: BACKGROUND; Vulvar Paget's disease comprises only 1-8% of malignant vulvar tumors. It is associated with an underlying carcinoma in 20-30% of cases. Clinically, it manifests as erythematous areas with hyperkeratotic plaques, accompanied by pruritus. Histologically, it is characterized by large, pale cells with mucicarmine-positive cytoplasm, isolated or in aggregates, in the epidermis. CASE: A 75-year-old woman presented with erythematous plaques covering the entire vulvar, vaginal and perianal area and pruritus. Smears were taken from all 3 sites and stained with Papanicolaou stain. Additionally, biopsies were taken from the vulva, vagina and outer borders of the lesion and were stained with hematoxylin-eosin and also for periodic acid-Schiff stain, CK7, CEA, S-100 and CK20. The cytologic examination revealed numerous round to columnar, moderately enlarged atypical cells, dispersed or in loose groups, with abundant clear cytoplasm, vesicular nuclei and prominent nucleoli. The histologic findings confirmed the cytologic diagnosis. No indication of an underlying adenocarcinoma was found. CONCLUSION: Although the histologic examination of a vulvar lesion is necessary in order to confirm the diagnosis of vulvar Paget's disease and rule out the possibility of an underlying invasive adenocarcinoma, the cytologic examination of vulvar smears is useful for alerting the clinician to the possibility of vulvar Paget's disease.


Assuntos
Doença de Paget Extramamária/patologia , Teste de Papanicolaou , Esfregaço Vaginal , Vulva/patologia , Neoplasias Vulvares/patologia , Idoso , Citoplasma/patologia , Feminino , Humanos
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