Cross-sectional field study comparing hippocampal subfields in patients with post-traumatic stress disorder, major depressive disorder, post-traumatic stress disorder with comorbid major depressive disorder, and adjustment disorder using routine clinical data.

Background: The hippocampus is a central brain structure involved in stress processing. Previous studies have linked stress-related mental disorders, such as post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), with changes in hippocampus volume. As PTSD and MDD have similar symptoms, clinical diagnosis relies solely on patients reporting their cognitive and emotional experiences, leading to an interest in utilizing imaging-based data to improve accuracy. Our field study aimed to determine whether there are hippocampal subfield volume differences between stress-related mental disorders (PTSD, MDD, adjustment disorders, and AdjD) using routine clinical data from a military hospital. Methods: Participants comprised soldiers (N = 185) with PTSD (n = 50), MDD (n = 70), PTSD with comorbid MDD (n = 38), and AdjD (n = 27). The hippocampus was segmented and volumetrized into subfields automatically using FreeSurfer. We used ANCOVA models with estimated total intracranial volume as a covariate to determine whether there were volume differences in the hippocampal subfields cornu ammonis 1 (CA1), cornu ammonis 2/3 (CA2/3), and dentate gyrus (DG) among patients with PTSD, MDD, PTSD with comorbid MDD, and AdjD. Furthermore, we added self-reported symptom duration and previous psychopharmacological and psychotherapy treatment as further covariates to examine whether there were associations with CA1, CA2/3, and DG. Results: No significant volume differences in hippocampal subfields between stress-related mental disorders were found. No significant associations were detected between symptom duration, psychopharmacological treatment, psychotherapy, and the hippocampal subfields. Conclusion: Hippocampal subfields may distinguish stress-related mental disorders; however, we did not observe any subfield differences. We provide several explanations for the non-results and thereby inform future field studies.

Nature videos for PTSD: protocol for a mixed-methods feasibility study.

Background: Given the prevalence of post-traumatic stress disorder (PTSD), particularly among military personnel, new treatment approaches are needed. One may be virtual relaxation interventions, especially 360-degree nature videos, since studies have demonstrated their relaxation effects for healthy participants. If these relaxation effects can be reproduced in patients with PTSD, they may offer a viable tool to reduce distress and hyperarousal. Objective: This research protocol describes a planned study that will examine the relaxation effects of 360-degree nature videos for patients with PTSD. It will also investigate whether these relaxation effects differ depending on the hardware immersion level (head-mounted display [HMD] vs. PC screen) in comparison to a control condition in which patients only listen to natural sounds and do not view a video. Finally, the effect of each intervention's dose duration (five vs. ten minutes) will be explored. Method: A counterbalanced, randomised, controlled, within-subject experiment will be conducted (sample size N = 36). Only soldiers aged 18 years or older with a primary diagnosis of PTSD will be included. Those with psychosis, substance dependence, a change in psychiatric medication within the last month, suicidal intent, and motion sickness will be excluded. All patients will experience the HMD, PC, and control conditions once for five or ten minutes. Self-reported relaxation measures will be collected before and after, and patients' skin conductance level, heart rate, and heart rate variability will be assessed during each condition. Semi-structured interviews will be conducted to examine the patients' experiences in detail. Conclusions: This feasibility study will provide initial evidence of whether viewing 360-degree nature videos via HMD or PC screen is relaxing for patients with PTSD and whether the effects are greater compared with the control condition. The study will also validate the dose duration and thereby informing a subsequent confirmatory interventional trial. Trial registration: DRKS00020277. HIGHLIGHTS: This randomised controlled feasibility study will examine whether 360-degree nature videos are a suitable relaxation intervention for military personnel with post-traumatic stress disorder.

Introducción: Dada la prevalencia del trastorno de estrés postraumático (TEPT), particularmente entre militares, se necesitan nuevos enfoques de tratamiento. Uno podría ser intervenciones de relajación virtual, especialmente videos de naturaleza de 360-grados, ya que los estudios han demostrado sus efectos de relajación para participantes sanos. Si estos efectos de relajación pueden reproducirse en pacientes con TEPT, podrían ofrecer una herramienta viable para reducir la angustia y la hiperalerta.Objetivo: Este protocolo de investigación describe un estudio planificado que examinará los efectos de relajación con videos de naturaleza de 360-grados, para pacientes con TEPT. También investigará de qué manera estos efectos de relajación difieren dependiendo del nivel de inmersión del hardware (pantalla montada en la cabeza [HMD] vs. pantalla de PC) en comparación con una condición de control en la que los pacientes solo escuchan los sonidos de la naturaleza y no ven un video. Finalmente, el efecto de la duración de la dosis de cada intervención (cinco vs diez minutos) será explorados.Método: Se llevará a cabo un experimento contrabalanceado, aleatorizado, controlado e intrasujeto (tamaño de muestra N = 36). Solo serán incluidos los soldados de 18 años o más con un diagnóstico primario de TEPT. Serán excluidos aquellos con psicosis, dependencia de sustancias, un cambio en la medicación psiquiátrica en el último mes y quienes presenten ideación suicida o cinetosis (mareo de movimiento). Todos los pacientes experimentarán las condiciones de HMD, PC y control una vez durante cinco o diez minutos. Las mediciones de relajación autoreportadas se recopilarán antes y después y el nivel de conductancia de la piel de los pacientes, la frecuencia cardíaca y la variabilidad de la frecuencia cardíaca se evaluarán durante cada condición. Se realizarán entrevistas semiestructuradas para examinar las experiencias de los pacientes en detalle.Conclusiones: Este estudio de factibilidad proporcionará evidencia inicial de si visualizar videos de naturaleza de 360-grados a través de HMD o la pantalla de la PC es relajante para los pacientes con TEPT, y si los efectos son mayores comparados con la condición de control. El estudio también validará la duración de la dosis y operacionalización de los puntos de termino, informando así un ensayo interventivo confirmatorio posterior.

Virtual Trauma Interventions for the Treatment of Post-traumatic Stress Disorders: A Scoping Review.

Some post-traumatic stress disorder (PTSD) patients do not benefit from imaginal exposure therapy. One possible approach to reach such patients are virtual trauma interventions. Herein, a qualitative scoping review was conducted. Different types of virtual trauma exposure interventions were identified. For each type of virtual trauma exposure interventions it was examined in detail: (1) which in sensu trauma exposure approach serves as therapeutic framework, how it was transferred into virtual reality, and if it was manualized; (2) which hardware and software were used; (3) whether the influence of spatial and social presence on the efficacy of virtual trauma interventions have been measured, and (4) whether the efficacy of virtual trauma interventions for PTSD patients having imagination difficulties was evaluated. These research questions were analyzed qualitatively. Accordingly, an extensive literature search was conducted using the databases Web of Science, PsycINFO, LIVIVO, PTSDpubs, and PubMed for scientific articles published between January 2013 and July 2020. Only studies aimed to reduce PTSD symptoms using virtual trauma interventions were included. The literature search was not limited to a specific study design, treatment/intervention method, or a minimum sample size. Eighteen studies were identified, which reported three different virtual trauma intervention approaches, namely, virtual reality exposure therapy (VRET), multi-modular motion-assisted memory desensitization and reconsolidation (3MDR), and action-centered exposure therapy (ACET). Seven randomized controlled trials (RCTs), two pilot studies, and one case study were focused on VRET; while two RCTs, one pilot study, and three case studies focused on 3MDR, and two case studies on ACET. Regarding the first research question (1), the results show that VRET is based on prolonged exposure, aiming for a virtual re-creation of the patient's traumatic recounting. Several treatment protocols exist for VRET. 3MDR is based on eye movement desensitization and reprocessing, aiming to reduce the patient's avoidance behavior. In 3MDR patients walk toward individualized trauma-related symbolic images in a cave automatic virtual environment (CAVE). One treatment protocol exists for 3MDR. ACET is based on the inhibitory learning theory, aiming for active interactions with a virtual trauma-associated environment to alter the anxiety structure through new secondary inhibitory learning. One treatment protocol exists for ACET. For the second research question (2), the results indicate that all VRET studies used head-mounted displays (HMDs) with a virtual version of the Iraq/Afghanistan or the World Trade Center attacks, while 3MDR studies utilized two different versions of a CAVE with personalized trauma-related images, and the ACET studies used HMDs with virtual street scenarios. For the third research question (3), the results demonstrate that the influence of spatial or social presence on the efficacy of virtual trauma interventions was not examined in any of the included studies. Similarly, for the fourth research question (4), the results show that empirical evidence for the efficacy of virtual trauma interventions on PTSD patients having imagination difficulties was lacking. Therefore, such empirical studies are needed to fill these research gaps.

Psychometric evaluation of the Hamburg Nightmare Questionnaire (HNQ).

Background: Nightmares are a widespread phenomenon. In comparison to the general population, they occur in mentally ill and especially in traumatized individuals with an increased frequency. Despite the high prevalence, there is no short questionnaire in the German language that is able to characterize nightmares, to differentiate between different nightmare types and to assess their impact on daytime functioning. Objective: The Hamburg Nightmare Questionnaire (HNQ) has been developed as a short self-rating instrument to fill this gap. Method: Psychometric characteristics of the HNQ were evaluated in a sample of 707 German soldiers passing through the standard diagnostics of the Center for Mental Health at the German Armed Forces Hospital Hamburg. Results: The results of this study show satisfactory psychometric characteristics as a sound factorial structure and adequate internal consistency for the HNQ as well as initial indications of the construct validity of its subscales. Conclusions: The HNQ is a reliable and economic tool for the assessment of posttraumatic nightmares in clinical as well as research settings.

Antecedentes: Las pesadillas son un fenómeno ampliamente generalizado. En comparación con la población general, las pesadillas ocurren con una mayor frecuencia en personas con enfermedad mental y, especialmente, en personas traumatizadas. A pesar de su alta prevalencia, no existe ningún cuestionario breve en idioma alemán que sea capaz de caracterizar las pesadillas, diferenciarlas en tipos, y evaluar su impacto sobre la funcionalidad durante el periodo de vigilia.Objetivo: Se desarrolló el Cuestionario de Pesadillas de Hamburgo (HNQ, por sus siglas en inglés) como un instrumento de valoración breve auto-aplicado para subsanar esta brecha.Método: Se evaluaron las características psicométricas del HNQ a partir de una muestra de 707 soldados alemanes que eran sometidos a los diagnósticos estándar del Centro para la Salud Mental del Hospital de Hamburgo de las Fuerzas Armadas Alemanas.Resultados: Los resultados de este estudio mostraron características psicométricas satisfactorias, tales como una firme estructura factorial y una adecuada consistencia interna para el HNQ, así como indicadores iniciales de la validez del constructo de sus subescalas.Conclusiones: El HNQ es una herramienta confiable y económica para la evaluación de pesadillas postraumáticas tanto en el ámbito clínico como en el de investigación.