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1.
Am J Obstet Gynecol ; 163(1 Pt 1): 130-7, 1990 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-2197863

RESUMO

To assess the association between women with preterm premature rupture of membranes and 41 potential risk factors, we conducted a case-control study in six United States tertiary perinatal centers. The study involved completion of a comprehensive questionnaire for 341 women with preterm premature rupture of membranes in singleton pregnancies from 20 to 36 weeks' gestation and 253 control women matched for maternal age, gestational age, parity, clinic or private patient status, and previous vaginal or cesarean delivery. Univariate analysis revealed 11 variables associated with a significantly (p less than 0.05) increased risk of preterm premature rupture of membranes. After multiple logistic regression analysis, three variables remained in the model as independent risk factors: antepartum vaginal bleeding in more than one trimester (odds ratio 7.4; 95% confidence interval, 2.2, 25.6), current cigarette smoking (odds ratio, 2.1; 95% confidence interval, 1.4, 3.1), and previous preterm delivery (odds ratio, 2.5; 95% confidence interval, 1.4, 2.5). Cessation of cigarette smoking by pregnant women may reduce the risk of preterm premature rupture of membranes. Further study is necessary to determine the nature of the relationship between antepartum vaginal bleeding and preterm premature rupture of membranes.


Assuntos
Ruptura Prematura de Membranas Fetais/etiologia , Recém-Nascido Prematuro , Estudos de Casos e Controles , Feminino , Humanos , Recém-Nascido , Prontuários Médicos , Estudos Multicêntricos como Assunto , Gravidez , Complicações na Gravidez , Estudos Prospectivos , Fatores de Risco , Comportamento Sexual , Fumar/efeitos adversos , Inquéritos e Questionários , Hemorragia Uterina/complicações
3.
J Pediatr ; 94(2): 190-3, 1979 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-762605

RESUMO

The mean serum concentration of 24,25(OH)2D determined by competitive protein-binding radioassay was significantly lower in ten uremic children maintained on hemodialysis (0.82 +/- 0.43[SD] ng/ml) than in ten patients with impaired renal function not requiring hemodialysis (1.30 +/- 0.54 ng/ml, P less than 0.05), or in 12 normal children (2.98 +/- 1.57 ng/ml, P less than 0.01). The serum levels of 250HD were similar in all groups. There were significant (P less than 0.01) positive correlations between the serum concentration of 24,25(OH)2D or the ratio 24,25(OH)2D/25OHD and the creatinine clearance. The serum concentration of 24,25(OH)2D was significantly decreased also in six anephric adults relative to normal adult values. The data indicate that production of 24,25(OH)2D is impaired in subjects with compromised renal function. Inasmuch as the major active metabolite of Vitamin D, i.e., 1,25(OH)2D, is requried for renal synthesis of 24,25(OH)2D measurement of the latter metabolite may provide a convenient method for assessment of renal vitamin D metabolism. The role of this metabolite in the pathogenesis of renal osteodystrophy remains speculative.


Assuntos
Di-Hidroxicolecalciferóis/sangue , Hidroxicolecalciferóis/sangue , Rim/metabolismo , Uremia/sangue , Criança , Humanos , Diálise Renal , Uremia/terapia
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