Characteristics of individuals who developed type 2 diabetes from prediabetes despite undergoing interventions, and evaluation of the performance of urinary myo-inositol as a risk factor for developing diabetes.

AIMS/INTRODUCTION: The aim of this study was to clarify the characteristics of individuals with prediabetes who developed type 2 diabetes despite undergoing interventions, and to evaluate the performance of urinary myo-inositol (UMI) as a noninvasive indicator for the risk of developing diabetes. MATERIALS AND METHODS: A total of 51 individuals with prediabetes who underwent a 75-g oral glucose tolerance test, ΔUMI (the difference in the UMI : creatinine ratio between before and 120 min after 75-g glucose loading), fasting plasma glucose, insulin, hemoglobin A1c, noninvasive testing (age, body mass index, blood pressure) and general blood tests were measured at baseline, and underwent dietary/exercise guidance for 8 years were studied. RESULTS: A total of 31 participants developed diabetes in 8 years. At baseline, the group that developed diabetes was characterized by high ΔUMI, hemoglobin A1c, fasting plasma glucose and low high-density lipoprotein cholesterol, and insulinogenic index (I.I.). I.I and ΔUMI showed a higher correlation than fasting plasma glucose and hemoglobin A1c. Regarding diabetes onset within 8 years, Cox regression analysis of diabetes onset showed the baseline ΔUMI is an independent predictor, adjusted for the result of not only noninvasive markers, but also that of noninvasive and general blood markers. The log-rank test showed that all glycemic indicators were significantly associated with diabetes onset. CONCLUSION: Participants who developed type 2 diabetes from prediabetes despite undergoing interventions were characterized by high glycemic control markers and low I.I. As noninvasive measurement of ΔUMI is associated with I.I. and diabetes onset, it could be a useful indicator for identifying individuals with a high risk of diabetes onset.

Effect of High Moisture Ear Corn and High Moisture Shelled Corn Feeds on Laying Hen Performance.

The aim of the study was to test the effect of high moisture ear corn (HMEC) and high moisture shelled corn (HMSC) feeds on laying hen performance. A total of 108 Rhode Island Red laying hens were divided by body weight and performance into 12 blocks (9 in each). Each block was assigned to one of three dietary treatments. The hens were fed one of three experimental diets containing 48.0% commercial laying hen diet (CON), 55.7% HMEC (EC) or 48.5% HMSC (SC) on a dry matter (DM) basis. All diets were isocaloric (2.80 mega calorie (Mcal) of (metabolizable energy (ME)/kg of DM) and isonitrogenous (15.5% CP of DM). DM Feed intake (139 to 148 g DM/d per hen), egg production rate (79 to 85%), egg mass (47.6 to 51.2 g/d per hen) and feed utilization (2.7 to 3.1 g of feed DM/g of egg) were not affected by diet. Body weight for the SC diet was significantly less than that for the CON diet (P<0.05). This was possibly due to the low feed intake during weeks 1 and 2 because of the short adaptation period to the experimental diet. The body weight loss of hens fed the SC diet may not have occurred when there had been a sufficient adaptation period. Eggshell strength (3.27 to 3.52 kg/cm2) and Haugh unit (80.0 to 83.6) were not affected by diet. In conclusion, HMEC and HMSC diets do not significantly affect laying hen performance and can be used as a main ingredient of the laying hen diet.