[First Report of Intraorbital Abscess Caused by Candida allociferrii and Specific PCR for Differentiating Stephanoascus ciferrii Complex Species].

We present a rare case of intraorbital abscess caused by Candida allociferrii, which was described as a new species of Stephanoascus ciferrii complex in 2002, in a patient after enucleation of choroidal melanoma. This strain showed resistance to itraconazole, and fluconazole. After debridement and topical use of amphotericin B, his wound abscess was disappeared. To our knowledge, this is the first C. allociferrii infection case in human.

Ocular perivascular epithelioid cell tumor: report of 2 cases with distinct clinical presentations.

Perivascular epithelioid cell tumors comprise a rare and recently described family of neoplasms that characteristically coexpress melanocytic and myoid markers. We describe the clinicopathologic features of 2 ocular cases. Case 1 occurred in a 26-year-old woman with a recurrent left upper eyelid tumor, and case 2 was diagnosed in a 7-year-old boy with a left ciliary body mass. This is the first report of perivascular epithelioid cell tumor arising in the ciliary body or eyelid. Neither patient in our series had documented evidence of the tuberous sclerosis complex. Despite its rarity, perivascular epithelioid cell tumor should be considered in the differential diagnosis of ocular melanocytic lesions. Although most examples appear cytologically bland, experience is limited regarding their malignant potential; and therefore, complete surgical resection and close follow-up are recommended.

Transpupillary thermotherapy for vasoproliferative retinal tumor.

PURPOSE: To report the clinical course of a patient with vasoproliferative retinal tumor (VPRT) who was treated with transpupillary thermotherapy (TTT). METHODS: A 50-year-old asymptomatic woman who had undergone fundus examination as a part of a preventive medical examination and been diagnosed with a retinal tumor in the left eye was referred to our hospital. Photocoagulation failed to inhibit progression of the massive serous detachment that accompanied the tumor, and TTT was performed with an 810-nm diode laser with a 4.0-mm spot size at 500 mW to 750 mW for 60 seconds with a 1-month interval between 2 treatments. Four and two partially overlapping laser spots were applied to cover the entire tumor in the first and second treatment sessions, respectively. As a result, the laser was applied to the tumor until the lesion become white. RESULTS: The serous retinal detachment and macular edema had almost completely resolved after two sessions of TTT. Thirteen months after TTT, there was no recurrence of the tumor. CONCLUSION: There were no complications associated with TTT for VPRT. Further follow-up of this case as well as accumulative data from other case reports is still needed, but TTT may be effective for treating VPRT with severe retinal detachment.

[Long-term prognosis of 29 patients with uveal malignant melanoma who were operated on by local resection or enucleation].

PURPOSE: The prognosis after surgical treatment (local resection or enucleation) of uveal malignant melanoma was investigated. METHODS: Twenty-nine patients with uveal malignant melanoma were operated on from August, 1989 to December, 2005. We evaluated the prognosis of the cases according to the operative method (local resection or enucleation), size of tumors, histological types, and presence of scleral invasion. RESULTS: 14 patients underwent local resection and 15 patients underwent enucleation of the eyeball. The five year survival rate was 100% in the case of local resection, and 66% in the case of enucleation. More patients who had large tumors died than patients who had small tumors. The five year survival rate was 100% in spindle A, mixed, and epithelioid type, and 69% in spindle B type. Five year survival rate was 67% in the patients who had scleral invasion, and 92% in the patients who did not have scleral invasion. CONCLUSIONS: In our series, local resection did not worsen the prognosis of the cases of choroidal malignant melanoma compared with the case of enucleation.

No evidence of a correlation between BCL10 expression and API2-MALT1 gene rearrangement in ocular adnexal MALT lymphoma.

In the present study, 62 cases of ocular adnexal lymphoproliferative disorders were reviewed clinicopathologically. Of them, 51 were extranodal marginal zone B-cell lymphoma (MALT lymphoma), five were diffuse large B-cell lymphoma (DLBCL), one was peripheral T-cell lymphoma, one was NK/T cell lymphoma, nasal type, and four were reactive lymphoid hyperplasia. These lymphoma cases showed a favorable clinical course and localized disease, except for the case of NK/T cell lymphoma, although 19 cases (32.8%) had a recurrence of disease. To clarify the correlation between BCL10 protein expression and API2-MALT1 gene rearrangement, the 51 cases of MALT lymphoma and 5 cases of DLBCL were analyzed by immunohistochemical and RT-PCR methods. Nuclear BCL10 expression was identified in 58% of MALT lymphoma cases, but not in any DLBCL cases. There was no evidence of a correlation between aberrant nuclear BCL10 expression and the clinical parameters examined in the present study. API2-MALT1 transcription was not demonstrated in either the MALT lymphoma cases or the DLBCL cases studied using a multiplex one-tube reverse transcriptase-PCR method. These findings indicate that the nuclear expression of BCL10 is unlikely to correlate with the API2-MALT1 fusion gene in ocular adnexal MALT lymphoma.

Bilateral iris metastases from prostate cancer.

BACKGROUND: Iris metastases of malignant tumors are not common, and most of the cases are unilateral. To our knowledge, there has been no report of bilateral iris tumors metastasized from prostate cancer. CASE: A 71-year-old man with a history of prostate cancer presented with bilateral iris tumors and secondary glaucoma. He had had multiple bone metastases, and had undergone chemotherapy. OBSERVATIONS: Gray-white fleshy tumors spread in the iris of both eyes. Iridocyclitis and secondary glaucoma were present. After external beam radiotherapy, the iris tumors regressed remarkably in volume. CONCLUSIONS: We observed a rare case of bilateral iris tumors, which had probably metastasized from prostate cancer. The tumors were well controlled with conservative therapies including radiation. We believe this article is the first report of bilateral iris tumors metastasized from prostate cancer.