NENet: Nested EfficientNet and adversarial learning for joint optic disc and cup segmentation.

Glaucoma is an ocular disease threatening irreversible vision loss. Primary screening of Glaucoma involves computation of optic cup (OC) to optic disc (OD) ratio that is widely accepted metric. Recent deep learning frameworks for OD and OC segmentation have shown promising results and ways to attain remarkable performance. In this paper, we present a novel segmentation network, Nested EfficientNet (NENet) that consists of EfficientNetB4 as an encoder along with a nested network of pre-activated residual blocks, atrous spatial pyramid pooling (ASPP) block and attention gates (AGs). The combination of cross-entropy and dice coefficient (DC) loss is utilized to guide the network for accurate segmentation. Further, a modified patch-based discriminator is designed for use with the NENet to improve the local segmentation details. Three publicly available datasets, REFUGE, Drishti-GS, and RIM-ONE-r3 were utilized to evaluate the performances of the proposed network. In our experiments, NENet outperformed state-of-the-art methods for segmentation of OD and OC. Additionally, we show that NENet has excellent generalizability across camera types and image resolution. The obtained results suggest that the proposed technique has potential to be an important component for an automated Glaucoma screening system.

IDRiD: Diabetic Retinopathy - Segmentation and Grading Challenge.

Diabetic Retinopathy (DR) is the most common cause of avoidable vision loss, predominantly affecting the working-age population across the globe. Screening for DR, coupled with timely consultation and treatment, is a globally trusted policy to avoid vision loss. However, implementation of DR screening programs is challenging due to the scarcity of medical professionals able to screen a growing global diabetic population at risk for DR. Computer-aided disease diagnosis in retinal image analysis could provide a sustainable approach for such large-scale screening effort. The recent scientific advances in computing capacity and machine learning approaches provide an avenue for biomedical scientists to reach this goal. Aiming to advance the state-of-the-art in automatic DR diagnosis, a grand challenge on "Diabetic Retinopathy - Segmentation and Grading" was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI - 2018). In this paper, we report the set-up and results of this challenge that is primarily based on Indian Diabetic Retinopathy Image Dataset (IDRiD). There were three principal sub-challenges: lesion segmentation, disease severity grading, and localization of retinal landmarks and segmentation. These multiple tasks in this challenge allow to test the generalizability of algorithms, and this is what makes it different from existing ones. It received a positive response from the scientific community with 148 submissions from 495 registrations effectively entered in this challenge. This paper outlines the challenge, its organization, the dataset used, evaluation methods and results of top-performing participating solutions. The top-performing approaches utilized a blend of clinical information, data augmentation, and an ensemble of models. These findings have the potential to enable new developments in retinal image analysis and image-based DR screening in particular.

Retinal image analysis for disease screening through local tetra patterns.

Age-related Macular Degeneration (AMD) and Diabetic Retinopathy (DR) are the most prevalent diseases responsible for visual impairment in the world. This work investigates discrimination potential in the texture of color fundus images to distinguish between diseased and healthy cases by avoiding the prior lesion segmentation step. It presents a retinal background characterization approach and explores the potential of Local Tetra Patterns (LTrP) for texture classification of AMD, DR and Normal images. Five different experiments distinguishing between DR - normal, AMD - normal, DR - AMD, pathological - normal and AMD - DR - normal cases were conducted and validated using the proposed approach, and promising results were obtained. For all five experiments, different classifiers namely, AdaBoost, c4.5, logistic regression, naive Bayes, neural network, random forest and support vector machine were tested. We experimented with three public datasets, ARIA, STARE and E-Optha. Further, the performance of LTrP is compared with other texture descriptors, such as local phase quantization, local binary pattern and local derivative pattern. In all cases, the proposed method obtained the area under the receiver operating characteristic curve and f-score values higher than 0.78 and 0.746 respectively. It was found that both performance measures achieve over 0.995 for DR and AMD detection using a random forest classifier. The obtained results suggest that the proposed technique can discriminate retinal disease using texture information and has potential to be an important component for an automated screening solution for retinal images.

Statistical Geometrical Features for Microaneurysm Detection.

Automated microaneurysm (MA) detection is still an open challenge due to its small size and similarity with blood vessels. In this paper, we present a novel method which is simple, efficient, and real-time for segmenting and detecting MA in color fundus images (CFI). To do this, a novel set of features based on statistics of geometrical properties of connected regions, that can easily discriminate lesion and non-lesion pixels are used. For large-scale evaluation proposed method is validated on DIARETDB1, ROC, STARE, and MESSIDOR dataset. It proves robust with respect to different image characteristics and camera settings. The best performance was achieved on per-image evaluation on DIARETDB1 dataset with sensitivity of 88.09 at 92.65% specificity which is quite encouraging for clinical use.

Localization of optic disc and fovea in retinal images using intensity based line scanning analysis.

Accurate detection of diabetic retinopathy (DR) mainly depends on identification of retinal landmarks such as optic disc and fovea. Present methods suffer from challenges like less accuracy and high computational complexity. To address this issue, this paper presents a novel approach for fast and accurate localization of optic disc (OD) and fovea using one-dimensional scanned intensity profile analysis. The proposed method utilizes both time and frequency domain information effectively for localization of OD. The final OD center is located using signal peak-valley detection in time domain and discontinuity detection in frequency domain analysis. However, with the help of detected OD location, the fovea center is located using signal valley analysis. Experiments were conducted on MESSIDOR dataset, where OD was successfully located in 1197 out of 1200 images (99.75%) and fovea in 1196 out of 1200 images (99.66%) with an average computation time of 0.52s. The large scale evaluation has been carried out extensively on nine publicly available databases. The proposed method is highly efficient in terms of quickly and accurately localizing OD and fovea structure together compared with the other state-of-the-art methods.

Rotation-invariant texture image retrieval using rotated complex wavelet filters.

This paper proposes a novel approach for rotation-invariant texture image retrieval by using set of dual-tree rotated complex wavelet filter (DT-RCWF) and DT complex wavelet transform (DT-CWT) jointly, which obtains texture features in 12 different directions. Two-dimensional RCWFs are nonseparable and oriented, which improves characterization of oriented textures. Robust and efficient isotropic rotationally invariant features are extracted from DT-RCWF and DT-CWT decomposed subbands. This paper demonstrates the effectiveness of this new set of features on four different sets of rotated and nonrotated databases. Experimental results indicate that the proposed method improves retrieval accuracy from 83.17% to 93.71% on a small size (208 images) nonrotated database D1, from 82.71% to 90.86% on a small size (208 images) rotated database D2, from 72.18% to 76.09% on a medium-size (640 images) rotated database D3, and from 64.17% to 78.93% on a large size (1856 images) rotated database D4, compared with the discrete wavelet transform-based approach. New method also retains comparable levels of computational complexity.

Texture image retrieval using new rotated complex wavelet filters.

A new set of two-dimensional (2-D) rotated complex wavelet filters (RCWFs) are designed with complex wavelet filter coefficients, which gives texture information strongly oriented in six different directions (45 degrees apart from complex wavelet transform). The 2-D RCWFs are nonseparable and oriented, which improves characterization of oriented textures. Most texture image retrieval systems are still incapable of providing retrieval result with high retrieval accuracy and less computational complexity. To address this problem, we propose a novel approach for texture image retrieval by using a set of dual-tree rotated complex wavelet filter (DT-RCWF) and dual-tree-complex wavelet transform (DT-CWT) jointly, which obtains texture features in 12 different directions. The information provided by DT-RCWF complements the information generated by DT-CWT. Features are obtained by computing the energy and standard deviation on each subband of the decomposed image. To check the retrieval performance, texture database D1 of 1856 textures from Brodatz album and database D2 of 640 texture images from VisTex image database is created. Experimental results indicates that the proposed method improves retrieval rate from 69.61% to 77.75% on database D1, and from 64.83% to 82.81% on database D2, in comparing with traditional discrete wavelet transform based approach. The proposed method also retains comparable levels of computational complexity.