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2.
Med Sci Monit ; 21: 585-97, 2015 Feb 24.
Artigo em Inglês | MEDLINE | ID: mdl-25708246

RESUMO

The aim of this study is to present the available and verified methods of prevention of cognitive decline in healthy older adults and to review clinical trials of therapies to improve impaired cognitive performance. We discuss data about the actual possibility of pharmacological treatment, usefulness of physical exercises, and effectiveness of different cognitive training methods. In a separate chapter we discuss why older people cope much better in life challenges then it would appear from the measurements made by use of neuro-psychological tests. We also discuss the so-called issue of transfers, ie, the question of how certain cognitive characteristics, improved through cognitive training, are transferred to other mental skills. We distinguish between simple and sophisticated (usually computerized) forms of cognitive training and pay particular attention to methods that are simple and easy to use. In particular, we discuss the so-called "learning therapy", which amounts to "reading aloud and simple arithmetic calculations", the method based on "switching between words and imagination", and also the method consisting of personal counseling, support, and assistance in learning, especially in the form of home visits. In the final chapter we formulate practical advice, not only for individuals who want to undertake the preventing or correction activities alone with eventual help of medical professionals, but also for the members of health institutions that wish to implement preventive and therapeutic actions directed to a chosen population. We also discuss the indications and rationale for further research and clinical trials.


Assuntos
Transtornos Cognitivos/prevenção & controle , Transtornos Cognitivos/terapia , Guias de Prática Clínica como Assunto , Idoso , Cognição , Transtornos Cognitivos/epidemiologia , Transtornos Cognitivos/psicologia , Disfunção Cognitiva/prevenção & controle , Disfunção Cognitiva/terapia , Humanos , Testes Neuropsicológicos
3.
Med Sci Monit ; 20: 2733-9, 2014 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-25524993

RESUMO

Older people often exhibit memory impairments. Contemporary demographic trends cause aging of the society. In this situation, it is important to conduct clinical trials of drugs and use training methods to improve memory capacity. Development of new memory tests requires experiments on animals and then clinical trials in humans. Therefore, we decided to review the assessment methods and search for tests that evaluate analogous cognitive processes in animals and humans. This review has enabled us to propose 2 pairs of tests of the efficiency of working memory capacity in animals and humans. We propose a basic set of methods for complex clinical trials of drugs and training methods to improve memory, consisting of 2 pairs of tests: 1) the Novel Object Recognition Test - Sternberg Item Recognition Test and 2) the Object-Location Test - Visuospatial Memory Test. We postulate that further investigations of methods that are equivalent in animals experiments and observations performed on humans are necessary.


Assuntos
Memória/fisiologia , Testes Neuropsicológicos , Animais , Humanos , Pesquisadores , Estatística como Assunto
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