[Syndrome of optic nerve atrophy, diabetes mellitus and diabetes insipidus]. / O sindrome atrofii zritel'nykh nervov, sakharnogo i nesakharnogo diabeta.

The paper is concerned with a case of a familial variant of the hereditary De Lawter syndrome, optic nerve atrophy coupled with diabetes mellitus and insipidus. Double diabetes was detected in two brothers. Their uncle suffered from deaf-mutism. Diabetes mellitus was insulin-dependent, diabetes insipidus responded well to adiurekrin, pituitrin, chloropropamide; optic nerve atrophy was characterized by white discs with clearly defined borders. Apparently, the syndrome is based on several mutant genes the action of which manifests as isolated and in different combinations as well.

[The myocardial contractile function and central hemodynamics of patients with insulin-dependent diabetes mellitus during treatment]. / Sokratitel'naia funktsiia miokarda i tsentral'naia gemodinamika u bol'nykh insulinzavisimym sakharnym diabetom v protsesse lecheniia.

The results of echocardiographic investigation of 48 patients with type I diabetes mellitus (DM) were compared: 48 patients received routine therapy including diabetic management, insulin and vitamin therapy, 32 received this type of therapy plus a complex consisting of inosine, benphothiamine and pyridoxal phosphate. A considerable decrease in myocardial contractility and hemodynamic disorder were revealed against a background of DM decompensation in both groups of patients. Clinical improvement resulting from the use of the above complex showed good correlation with a positive course of echocardiographic values of myocardial contractility and pumping function. Elimination of myocardial insufficiency was accompanied by an increase in the stroke volume, ejection fraction, the rate of circulatory shortening of myocardial fibers, left ventricular mass, and a decrease in end diastolic and systolic volumes. The second type of therapy was well tolerated by the patients and made it possible to considerably lessen myocardial insufficiency and reduce a period of treatment in hospital as compared to routine therapy.

[Central hemodynamics, effectiveness of endocardial blood flow and general physical work capacity in impaired glucose tolerance and diabetes mellitus]. / Tsentral'naia gemodinamika, effektivnost' endokardial'nogo krovotoka i obshchaia fizicheskaia rabotosposobnost' pri pri narushennoi tolerantnosti k gliukoze i sakharnom diabete.

The end diastolic pressure, myocardial viability index and other parameters of myocardial contractility, as well as central hemodynamics and general physical working capacity were studied in 120 subjects, including 20 subjects with impaired glucose tolerance, 80 patients with diabetes mellitus, and a control group of 20 healthy subjects. In impaired glucose tolerance, a tendency to reduced endocardial blood flow and myocardial contractility as well as elevated end diastolic pressure were observed. The physical working capacity remained within normal. In decompensated diabetes mellitus, the efficacy of endocardial blood flow considerably reduced, the end diastolic pressure rose more than twofold, myocardial contractility deteriorated, the stroke volume decreased, the general physical working capacity sharply fell. In compensated diabetes mellitus, versus decompensated one, subendocardial perfusion and myocardial contractility improved, stroke volume increased; the exercise tolerance threshold rose but did not reach normal.