[Assessment of an association between fatty acid structure of lipids in pulmonary surfactant and 137Cs content in the body of children, residents of radiation-contaminated areas].

An evaluation of correlation between fatty acid composition in pulmonary surfactant lipids and 137Cs content in the body of children, residents of radiation-contaminated areas revealed that a increased incorporation of 137Cs promotes a disruption of fatty acid balance towards an increase in the saturation of the surfactant lipid complex, a destruction of lecithin fraction of surfactant, a decrease in antioxidant properties of surfactant system, an activation of lipid peroxidation processes in the respiratory area of lung by lipoxygenase type, a disturbance of polyunsaturated fatty acid metabolism on the stage of bioregulators-eicosanoid formation.

[Application BAA "Glucorn" for the correction fatty-acid composition of pulmonary surfactant lipids in children-residents of radiation contaminated territories].

During application of BAA "Glucorn" for the correction of fatty-acid composition of pulmonary surfactant lipids in children-residents of radiation contaminated territories detected changes, evidence about increasing adaptation-compensatory processes in lipid membrane structures of pulmonary surfactant and respiratory tracts epithelium, activation of enzymatic pathway conversion of polyunsaturated fatty acids in their derivations--eicosanoids in absence the changes lipid peroxydation.

[Evaluation of immunity parameters and free radical processes in children-residents of radioactive contaminated territories born to parents irradiated in childhood].

The children--residents of contaminated territories, born from mothers irradiated in their childhood had in remote period of the Chernobyl Disaster an increase in the frequency of disorders connected with immune system activation and depressive types, increase in intensity of free radical processes in blood serum and erythrocytes.

[Assessment of quercetin efficiency for correction of fatty acid composition of pulmonary surfactant lipids in children residents of the radioactive contaminated territories].

The correction with quercitin medication used for children residents of radioactive contaminated territories lead to changes in the lipid fatty acid spectrum of expired air condensate that were indicative of the increase in the antioxidant properties of pulmonary surfactant, the decrease in the activity of the lipid peroxidation process in the respiratory organs according to the lipoxigenese type, the increase in the unsaturated lipid complex of expired air condensate due to metabolic inactive linoleic and arachidonic polyunsaturated fatty acid.

[Comparative characteristic of fatty acid content of lipids from expired air condensate in children with recurrent bronchitis residing in radiative contaminated territories and "clear" regions concerning radionuclide contamination].

The differences in the fat acid spectrum of expired air condensate in children with recurrent bronchitis who are residents of the radiation contaminated territories and children with analogous diagnosis living in the "clear" region regarding the radionuclide contamination consisted in the increased saturation of lipid complex indices against the decrease in content of polyunsaturated fat acids, antioxidant properties of pulmonary surfactant and activity of adaptation-compensatory processes in lipid bilayer of its membrane structures.

[Estimation of lipid fatty acids in condensate of expired air in children-residents of radioactive contaminated territories].

The study of lipid fatty acid content in the condensate of an expired air by gas liquid chromatography revealed an activation of lipid peroxidation processes against a background of a decrease in the antioxidant properties of pulmonary surfactant and metabolic disorders of polyunsaturated fatty acids at the stage of the bioregulator-eikosanoid formation in children-residents of the radioactive contaminated territories.

[Comparative characteristic of some parameters of the surfactant pulmonary system in children-residents of radioactive contaminated territories and children born to participants of liquidation of Chernobyl accident consequences].

The study of lipid fat acid content in condensate of expired air with the help of the gas liquid chromatography revealed the increased sum of polyunsaturated fatty acids (PUFA) in a large measure of increased content of arachidonic and linolic PUFA in children-residents of radioactive contaminated territories in comparison with children born by participants of liquidation of Chernobyl accident consequences. It is evidence of more active processes of lipid peroxidation and shift of the balance of fatty acids to the side of omega-6 family.

[Bioelectrical activity of muscle tissue and some characteristics of intracellular methabolism in children living in radiation polluted areas].

Children who live in radiation polluted areas have been found with the help of cytochemical analysis of enzymatic spectrum of circulating lymphocytes to have less active energy creation processes taken place in mitochondrions. It is partially compensated by intensification of glycolytic reactions and involvement of lipids and amino acids in processes of energy creation. These changes on system level (the muscle system) were confirmed by electromyography. It is confirmed showing the decrease in bioelectrical activity and functional reserves of muscle tissue and clinically by signs of chronic fatigue signs.

[Nonrespiratory lung functions in children who have undergone the chronic effect of ionizing radiation as a result of the accident at the Chernobyl Atomic Electric Power Station]. / Nerespiratorni funktsiï leheniv u ditei, iaki zaznaly khronichnoho vplyvu ionizuiuchoho vyprominiuvannia v rezul'tati avariï na ChAES.

With the purpose of assessing the condition of nonrespiratory functions of the lungs in those children having been under chronic exposure to ionizing irradiation as a result of the Chernobyl accident in the time-related course of the post-accident period, an examination was done of 964 children free from clinically manifest pathology of the respiratory organs aged 5 to 14 years, residing in the zones of radiation control. Noted in the above children over the post-accident period are changes in indices for non-respiratory functions of the lungs suggesting diminution of respiratory moisture oozing, disordered production of pulmonary surfactant, with intensity of free-radical processes being rather high.

[Changes in the respiratory functional status of children exposed to the chronic effect of ionizing radiation as a consequence of the Chernobyl catastrophe]. / Zminy funktsional'noho stanu dykhannia u ditei, iaki zaznaly khronichnoho vplyvu ionizuiuchoho vyprominiuvannia vnaslidok Chornobyl's'koï katastrofy.

Investigating the functions of the respiratory system some disorders of the ventilation capacity and the lung respiratory functions, external respiration, hypoxic changes in circulatory type at the functional loadings were revealed in children exposed to chronic radiation effects during the postaccident period. It was supposed that an increase in the intensity of free radical processes in the body and the presence of dysadaptation conditions are the basis of changes revealed.