RESUMO
Study of polymorphic genes of pro- and anti-inflammatory cytokines (IL-4, IL-10, TNF-α) in patients with occupational allergic dermatoses showed significantly higher frequency of polymorphic variants of cytokine genes IL4 C589T, IL10 C819T, IL10 G1082A, IL10 C592A, and TNF G308A in comparison with the population control. The presence of homozygous variant IL10 G1082A--AA in 80% cases characterizes early disease development, i.e. within 3 years after the first exposure to the occupational factor.
Assuntos
Dermatite Atópica/genética , Interleucina-10/genética , Interleucina-4/genética , Doenças Profissionais/genética , Fator de Necrose Tumoral alfa/genética , Substituição de Aminoácidos , Asma/epidemiologia , Asma/genética , Estudos de Casos e Controles , Dermatite Atópica/epidemiologia , Eczema/epidemiologia , Eczema/genética , Estudos de Associação Genética , Predisposição Genética para Doença , Humanos , Doenças Profissionais/epidemiologia , Polimorfismo de Nucleotídeo ÚnicoRESUMO
Laboratory tests in occupational medicine get more importance and are used in clinical practice for diagnosis and evaluating the treatment efficiency, as well as for assessing risk of occupational, occupationally mediated diseases and more advanced forms of noninfectional diseases, to reveal early manifestations of diseases in workers exposed to hazardous work conditions. The article covers contemporary molecular technologies to diagnose and evaluate risk of occupational diseases, that are used nowadays in FSBI "RIOH" RAMS.
Assuntos
Técnicas de Diagnóstico Molecular/métodos , Doenças Profissionais/diagnóstico , Exposição Ocupacional/efeitos adversos , Tecnologia Biomédica/métodos , Humanos , Medicina do Trabalho/métodos , RiscoRESUMO
The article deals with factors causative of high social-economic importance of occupational skin diseases, presents parameters of occupational skin diseases prevalence, exogenous and endogenous risk factors of occupational skin diseases. This conditions appear to have negative influence on everyday life and occupational activities of the patients, induce lower quality of life and work performance. Pathogenesis and clinical signs, laboratory values characterizing atopic and allergic dermatitis are discussed. The authors necessitated a search of signs or complex of signs, that can point to predisposition for sensitization of individuals exposed to occupational hazards.