RESUMO
Two new penicillide derivatives, secopenicillides A (3) and B (4), were isolated along with penicillide (1) and purpactin A (2), and altenusin (5) and dehydroaltenusin (6), the antifungal substances of this fungus, from the extract of Penicillium simplicissimum IFM 53375. The absolute structures of 3 and 4 were determined by spectroscopic investigation and chemical correlation to penicillide (1). The absolute configuration of purpactin A (2) was determined by the chemical method.
RESUMO
Screening of Malbranchea filamentosa IFM 41300 for bioactive compounds led to the identification of 4-benzyl-3-phenyl-5H-furan-2-one (1) as a vasodilator and erythroglaucin (2). The structure of 1 was established on the basis of spectroscopic and chemical investigations. Compound 1 inhibited Ca2+-induced vasocintraction in aortic rings pretreated with high K+ (60mM) or norepinephrine. Finally, compound 1 did not exhibit activity against human pathogenic microorganisms.
Assuntos
Compostos de Benzil/química , Compostos de Benzil/farmacologia , Furanos/química , Furanos/farmacologia , Onygenales/química , Vasodilatadores/química , Vasodilatadores/farmacologia , Animais , Aorta Torácica/efeitos dos fármacos , Aorta Torácica/fisiologia , Compostos de Benzil/isolamento & purificação , Cálcio/farmacologia , Relação Dose-Resposta a Droga , Furanos/isolamento & purificação , Técnicas In Vitro , Espectroscopia de Ressonância Magnética , Masculino , Testes de Sensibilidade Microbiana , Estrutura Molecular , Potássio/farmacologia , Ratos , Ratos Wistar , Espectrometria de Massas por Ionização por ElectrosprayRESUMO
In the course of our research for new antifungal agents, two new meroterpenoids, penisimplicin A (1) and B (2), were isolated from Penicillium simplicissimum. The absolute structures of 1 and 2 were established by spectroscopic and chemical investigation. Penisimplicin A (1) and B (2) are rare examples of D-ring seco-meroterpenoids. Since compounds 1 and 2 showed no antifungal activities, the isolation of the compounds with antifungal activity will be attempted.