Assuntos
Arteriosclerose Obliterante/cirurgia , Hialuronoglucosaminidase/uso terapêutico , Isquemia/prevenção & controle , Doença Arterial Periférica/cirurgia , Complicações Pós-Operatórias/prevenção & controle , Idoso , Anastomose Cirúrgica , Arteriosclerose Obliterante/patologia , Constrição Patológica/patologia , Constrição Patológica/prevenção & controle , Feminino , Humanos , Isquemia/patologia , Masculino , Pessoa de Meia-Idade , Doença Arterial Periférica/patologia , Complicações Pós-Operatórias/patologia , Túnica Íntima/patologiaRESUMO
Chair of Neurology of the Advanced Medical Training Department of the Federal Educational Facility of the Higher Vocational Education Russian State Medical University under the Russian Public Health Ministry, Moscow, Russia. The article deals with the findings obtained in examining and treating a total of eighty-seven patients suffering from atherosclerosis obliterans of the lower-limb arteries with stage IIB and III chronic arterial insufficiency. Studied were impairments of the theological properties of the blood and plasma, erythrocytic deformability and the concentration of malonic dialdehyde in blood at admission to the hospital, upon completion of the course of conservative treatment, and after the reconstructive vascular intervention performed. It was determined that the leading mechanism disturbing oxygen utilization by tissues is a decrease in erythrocytic deformability, which promotes shunting of the arterial blood flow and persists after the surgical vascular reconstruction preformed.
Assuntos
Arteriosclerose Obliterante/cirurgia , Hemorreologia , Perna (Membro)/irrigação sanguínea , Arteriosclerose Obliterante/diagnóstico , Arteriosclerose Obliterante/fisiopatologia , Doença Crônica , Deformação Eritrocítica , Feminino , Seguimentos , Humanos , Masculino , Malondialdeído/sangue , Microcirculação , Pessoa de Meia-Idade , Modelos Biológicos , Procedimentos de Cirurgia Plástica , Índice de Gravidade de Doença , Fatores de Tempo , Resultado do TratamentoRESUMO
The present literature review pays primary attention to the pathophysiblogical and immunological grounds of the process of restenoses of vascular anastomoses after reconstructive interventions in patients with atherosclerosis obliterans. On the molecular, cellular and tissue levels, analysed herein are alterations leading to restenosis, also presenting the data concerning currently available methods of diagnosis of this pathological condition. In addition, methods aimed at preventing and treating restenoses are discussed.
