[Chronic granulomatous disease (in a 2-month-old infant)]. / Hronicna granulomatozna bolest (u odojceta od 2 meseca).

The paper describes a severe form of chronic granulomatous disease with onset in the neonatal period; the case presented is a 2-month-old male infant, coming from a family in which hid older brother died with signs of the same illness. The disease is rare. This is the second report in our literature. The clinical picture showing various severity confirms the heterogenity of the disease and difference in the gene expressivity. Further investigation involving the function of granulocytes in children with recurrent infections might help us to reveal this disease characterized by disfunction of granulocytes, more frequently.

[Familial leukemia]. / Familijarna leukemija.

Occurrence of familial leukaemia confirms the influence of genetic factors in the appearance of malignant diseases. Such cases were described in one generation, in distant relations of two and three generations and in monozygotic siblings. Either the same type of leukaemia was recorded or different types. This is thought to be caused by pathological gene transmission in interaction with environmental factors which increase the tendency to malignant diseases in these families. Two cases of familial type of leukaemia are presented in the paper; in one family the illness appeared among members of one generation, but in the other in two generations. In both families it was a question of acute lymphoblastic leukaemia. Other types of malignancy were not found, nor was any environmental factor confirmed to have influenced cancerogenesis. Cytogenetic studies of the patients did not show any deviation from the normal kariotype. The illness evolution was fatal. This is the second report of familial leukemia in Yugoslav literature.

[Epidemiology and etiology of acute leukoses in children]. / Epidemiologija i etiologija akutnih leukoza u dece.

In their work authors have analyzed some epidemiologic and etiologic data that can be taken as the elements of risk in leukemogenesis. The investigations have been done retrospectively in 212 children suffering from acute leukemia and treated in Pediatric Clinic in Beograd. Certain factors of risk are particularly studied as: repeated viral infections, repeated use of antibiotics, diagnostic and therapeutic irradiation of children, familiar data on congenital anomalies and cancer and same harmful prezygotic and prenatal influences of possible significance. The authors also presented the results of their cytogenetic investigations obtained from 32 children. It is especially pointed out the significance of detailed data taken from patients suffering from these diseases.

[Calculosis of biliary and urinary tracts in children with congenital hemolytic anemias. (Retrospective view of some published work and certain investigations)]. / Kalkuloza zucnih i urinarnih puteva u dece sa urodenim hemoliticnim anemijama. (Osvrt na neke pulikovane radove i sopstvena iskustva).

During the last ten years twenty children with hereditary haemolitic anemia were admitted to the Children's University Hospital. As hyperbilirubinemia is one of the factors influencing calculi formation, we made systematic examination of the biliary and urinary pathways, because throughout these the excretory activity of bilirubin and its compound urobilinogen is performed. Owing to such a procedure, out of twenty children ten were discovered to have biliary calculi and other ten biliary and urinary calculi. As far as we learned from the available literature, parallel examination of these two pathways in children hereditary haemolitic anemia had not been made before.