CHANGES IN IMMUNOLOGICAL INDICATORS UNDER THE INFLUENCE OF TREATMENT OF GENERALIZED PERIODONTITIS IN PATIENTS WITH MANIFESTATIONS OF PSYCHOEMOTIONAL STRESS.

OBJECTIVE: The aim: The aim of investigation was to determine the effect of the proposed treatment of patients with generalized periodontitis and psychoemotional stress on changes in the immune system of patients. PATIENTS AND METHODS: Materials and methods: The clinical and laboratory investigations were conducted to revealed the effectiveness of the proposal complex of adrenoblockers in complex treatment of generalized periodontitis in 40 patients with psychoemotional stress. To assess the effectiveness of the treatment, the level of cortisol in saliva was determined. 40 patients with chronic course of generalized periodontitis I-II grade were divided into two subgroups: main and control. For the treatment of main subgroup patients used a modified enhanced complex of adrenoblockers to suppress the manifestations of psychoemotional stress. RESULTS: Results: The effectiveness of usage of the proposed complex of adrenoblockers were revealed after treatment of main group patients. The complex of adrenoblockers lead to stabilization of the generalized periodontitis in patients with psychoemotional stress. Such combination of adrenoblockers oppresses main symptoms of psychoemotional stress in with generalized periodontitis as evidenced by the decrease of cortisol levels in the patients saliva. CONCLUSION: Conclusions: As a result of researches the obtained data testify to achievement of stabilization of pathological process in a periodontium. All this together demonstrates the beneficial effect of the proposed complex of adrenoblockers on the dystrophic-inflammatory process in the periodontium. Decreased levels of cortisol in saliva indicate a decrease in the manifestations of psychoemotional stress in patients with generalized periodontitis.

EFFECTІVENESS OF LASER THERAPY ІN COMPLEX TREATMENT OF HERPETIC STOMATITIS.

OBJECTIVE: The aim: The purpose of research is to improve the effectiveness of treatment by applying laser in complex treatment in patients with herpetic stomatitis. PATIENTS AND METHODS: Materials and methods: Were examined 47 people (22 men and 25 women) with acute herpetic stomatitis. The patіents' age was from 20 to 72 years. All patients underwent immunological tests such as (T-lymphocytes (CD3 +), T-helpers (CD4 +), cytotoxic T-lymphocytes (CD8 +), the content of immunoglobulins IgM, IgG, IgA and slgA in saliva to assess the іmmunological reactivity of the organism. RESULTS: Results: Clinical observations have shown that when using laser therapy, the results of treatment were better than in the control group. Positive dynamics was observed as early as 1-2 days after the start of laser use and was more pronounced when used in the early stages of the disease. The use of the laser promoted a more rapid suspension of new lesions, a decrease in pain syndrome, and a more rapid regression of herpetic lesions. We have found significant improvements in the arameters of cellular and humoral іmmunity in patients of the main group. CONCLUSION: Conclusions: Treatment of herpetic stomatitis is relevant and requires further improvement and the search for new methods. The use of a laser in the complex treatment of herpetic stomatitis has a positive effect on the course and іmmunological status of patients with herpetic stomatіtis. The manifestations of the disease healed faster, and the pain syndrome was less severe. Duration between іllness and treatment decreased on 19.7% and 26%. It is advіsable to include the method of treatment using a laser in the complex therapy of herpetic stomatitis.