RESUMO
Standard and high-risk groups of 77 children with neuroectodermal medulloblastoma were given sandwich chemotherapy. The former group was treated with high-dose chemotherapy complemented with autotransplantation of bone marrow and peripheral stem cells. The treatment proved effective: 7-year recurrence-free survival (0.66 +/- 0.05) (overall survival--0.67 +/- 0.05; recurrence-free--0.62 +/- 0.06). Sandwich chemotherapy administered in standard risk group was followed by 7-year recurrence-free survival (0.84 +/- 0.08). High-dose chemotherapy complemented with autotransplantation of bone marrow and peripheral stem cells in conjunction with high-dose chemotherapy resulted in 6-year recurrence-free survival: 0.77 +/- 0.08 in patients after high-dose chemotherapy and 0.46 +/- 0.10--without it.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Encefálicas/tratamento farmacológico , Meduloblastoma/tratamento farmacológico , Tumores Neuroectodérmicos Primitivos/tratamento farmacológico , Adolescente , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Transplante de Medula Óssea , Neoplasias Encefálicas/mortalidade , Neoplasias Encefálicas/radioterapia , Neoplasias Encefálicas/cirurgia , Neoplasias Cerebelares/tratamento farmacológico , Quimioterapia Adjuvante , Criança , Pré-Escolar , Intervalo Livre de Doença , Esquema de Medicação , Feminino , Humanos , Masculino , Meduloblastoma/mortalidade , Tumores Neuroectodérmicos Primitivos/mortalidade , Transplante de Células-Tronco de Sangue Periférico , Radioterapia Adjuvante , Transplante Autólogo , Resultado do TratamentoRESUMO
In vitro experiments were conducted to determine the impact of interleukin-2 (IL-2) on apoptosis and function of cytostatic-cultured lymphoid (mononuclear) cells (MNC) of peripheral blood from healthy subjects and children with cancer. Neither slight or any effect on vepesid-16 or carboplatin--cultured MNC apoptosis, nor any phytohemagglutinin--induced proliferation was found. By contrast, in carboplatin- cultured MNC from healthy subjects, IL-2 significantly potentiated their toxicity for tumor cells by producing interferon-gamma. It was concluded that IL-2 predominantly supported MNC functional activity rather than inhibited lymphoid MNC apoptosis in in vitro culture with cytostatic drugs.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia , Apoptose/efeitos dos fármacos , Interleucina-2/farmacologia , Leucócitos Mononucleares/efeitos dos fármacos , Leucócitos Mononucleares/parasitologia , Adolescente , Carboplatina/farmacologia , Criança , Pré-Escolar , Etoposídeo/farmacologia , Feminino , Humanos , Lactente , Leucócitos Mononucleares/fisiologia , MasculinoAssuntos
Leucemia/epidemiologia , Linfoma/epidemiologia , Adolescente , Fatores Etários , Linfoma de Burkitt/epidemiologia , Criança , Pré-Escolar , Interpretação Estatística de Dados , Feminino , Doença de Hodgkin/epidemiologia , Humanos , Lactente , Recém-Nascido , Leucemia Mieloide Aguda/epidemiologia , Modelos Lineares , Linfoma não Hodgkin/epidemiologia , Masculino , Distribuição de Poisson , Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiologia , Sistema de Registros , República de Belarus/epidemiologia , Fatores SexuaisAssuntos
Astrocitoma/epidemiologia , Neoplasias Encefálicas/epidemiologia , Neoplasias do Sistema Nervoso Central/epidemiologia , Ependimoma/epidemiologia , Glioma/epidemiologia , Tumores Neuroectodérmicos/epidemiologia , Adolescente , Fatores Etários , Astrocitoma/mortalidade , Neoplasias Encefálicas/mortalidade , Neoplasias do Sistema Nervoso Central/mortalidade , Criança , Pré-Escolar , Interpretação Estatística de Dados , Ependimoma/mortalidade , Feminino , Glioma/mortalidade , Humanos , Lactente , Recém-Nascido , Masculino , Tumores Neuroectodérmicos/mortalidade , Sistema de Registros , República de Belarus/epidemiologia , Fatores Sexuais , Análise de SobrevidaRESUMO
A retrospective review was carried out to evaluate the results of treatment (1989-1998) of 81 children, aged under 15, with primary medulloblastoma. Thirty-three patients received surgery and postoperative craniospinal radiotherapy; 48--adjuvant chemotherapy (VCR 1.5 mg/m2, i.v., 1 day; CCNU 75 mg/m2, per os, 1 day; cisplatin 80 mg/m2 or carboplatin 400 mg/m2, i.v., 1 day). Overall 9-year survival was 37 +/- 0.8%. This index in the adjuvant chemotherapy group was 59 +/- 0.8%, without chemotherapy--22 +/- 0.8%.
Assuntos
Antineoplásicos Alquilantes/uso terapêutico , Antineoplásicos/uso terapêutico , Carboplatina/uso terapêutico , Neoplasias Cerebelares/tratamento farmacológico , Cisplatino/uso terapêutico , Lomustina/uso terapêutico , Meduloblastoma/tratamento farmacológico , Adolescente , Fatores Etários , Antineoplásicos/administração & dosagem , Antineoplásicos Alquilantes/administração & dosagem , Carboplatina/administração & dosagem , Neoplasias Cerebelares/mortalidade , Neoplasias Cerebelares/radioterapia , Neoplasias Cerebelares/cirurgia , Quimioterapia Adjuvante , Criança , Pré-Escolar , Cisplatino/administração & dosagem , Terapia Combinada , Feminino , Humanos , Lomustina/administração & dosagem , Masculino , Meduloblastoma/mortalidade , Meduloblastoma/radioterapia , Meduloblastoma/cirurgia , Dosagem Radioterapêutica , Fatores Sexuais , Análise de Sobrevida , Fatores de TempoRESUMO
The functional status of the thyroid gland was evaluated in 63 children with Hodgkin's disease, aged 4-15 years, before, in the course of and 5 years after chemoradiation therapy. Thyroxin (T4), triiodothyronine (T3) and thyroid-stimulating hormone (TSH) in the blood were assayed. The disease was shown to disrupt the pituitary-thyroid system leading to hypothyroidism development which progressed as the disease advanced. While chemotherapy brought the balance between the peripheral thyroid hormone levels and TSH back to normal, thyroid function decreased again following radiotherapy of the neck. The most pronounced and persistent failure of the pituitary-thyroid system was registered with the total target dose of 30 Gy and higher. Irradiation in a dose of 20 Gy caused less disruption and the function was spontaneously restored within 12 months after the treatment.
