1.
RSC Adv
; 10(28): 16727-16731, 2020 Apr 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35498849
RESUMO
We developed conjugates between monoclonal antibody (mAb) and folic acid (FA) by using a tryptophan (Trp)-selective reaction, which yields relatively homogenous products compared to conventional methods. The obtained mAb-FA conjugates showed significant cellular cytotoxicity toward folate receptor-expressing cancer cells, demonstrating that the conjugates retained the Fc region's original function.