RESUMO
Aluminum sulfate, potash alum, ammonium alum, purified and unpurified nephelinic coagulant are assigned to the 3rd jeopardy class (moderately dangerous chemicals), sodium alum--to the 4th jeopardy class (slightly dangerous chemicals) at the single exposure. Local irritation of rabbit's skin was not revealed, but instillation into the eye results in conjunctivitis and purulent ophthalmitis. Aluminum sulfate and coagulants afflict the nervous system, liver and heart. The recommended MAC in the air of workplace for aluminum sulfate, potash alum, sodium alum and coagulants based on them is equal to 0.5 mg/m3.
Assuntos
Poluentes Ocupacionais do Ar , Compostos de Alúmen , Coagulantes , Saúde Ocupacional , Animais , Olho/efeitos dos fármacos , Coração/efeitos dos fármacos , Dose Letal Mediana , Fígado/efeitos dos fármacos , Concentração Máxima Permitida , Camundongos , Sistema Nervoso/efeitos dos fármacos , Coelhos , Ratos , Pele/efeitos dos fármacos , Local de TrabalhoAssuntos
Boratos/farmacocinética , Boratos/toxicidade , Compostos de Boro/farmacocinética , Compostos de Boro/toxicidade , Compostos de Magnésio , Magnésio/farmacocinética , Magnésio/toxicidade , Animais , Osso e Ossos/metabolismo , Boratos/sangue , Compostos de Boro/sangue , Encéfalo/metabolismo , Rim/metabolismo , Fígado/metabolismo , Magnésio/sangue , Masculino , Ratos , Testículo/metabolismo , Distribuição TecidualRESUMO
Multichamber toxicokinetic model studies of the resorption, distribution and excretion properties of poorly soluble substances in subchronic action of suspensions administered intragastrically can be the first step in prognosing the toxicokinetic properties of the inhaled aerosols of the substances mostly discharged from the respiratory into the gastrointestinal tract (GIT). The generally accepted quantitative characteristics of the particles' deposition and translocation into GIT can provide a further application of the model for a mathematical description of a prolonged inhalational exposure to some substances. This technique was tested with the boron compounds characterized by low solubility and revealed a good correlation between the prognosed and actual deposits of the substance in the organ and excretions. At the same time, detected were some qualitative and quantitative differences in the boron toxicokinetics influenced by magnesium deboride and hexaborate, which were explained by differences in their solubility.