[Effect of temperature on the development of chromosome aberrations in human blood lymphocytes irradiated in pulse and continuous modes at BARS-6 reactor].

Summarized results of 5 repeated experiments of comparative study of radiation effects of the pulse reactor BARS-6 either in a single pulse or a continuos irradiation mode on human lymphocytes are presented. Higher efficiency (30-40%) of continuous irradiation (exposure duration 1 h) rather than pulse irradiation with ultra-high dose rates (1-2.5) x 10(6) Gy/min (pulse duration 65 micros) was confirmed. The efficiency ratio did not depend on the temperature, 20 degrees C or 0 degrees C, during the exposure. Cell repair system and chromatin conformation influence on the results obtained is discussed.

[Optimization of laboratory assessment of the activity of an inflammatory process in patients with rheumatoid arthritis].

The paper proposes to measure the serum content of medium-weight molecules as a simple and available means of rapidly and adequately assessing the total activity of an inflammatory process (including the minimal one) in patients with rheumatoid arthritis. The method may be performed at any powered clinical diagnostic laboratories; it does not require expensive reagents and equipment, and special staff training.

[Cytogenetic effect of the pulse reactor BARS-6 continuous or one-time irradiation with ultrahigh dose rate on human lymphocytes].

The results of the comparative study of radiation effects of the pulse reactor BARS-6 either in single pulse or continuos irradiation mode on human G0 lymphocytes are presented. Under identical doses the cytogenetic efficiency was observed to be higher for continuous irradiation (1 hour) than for single pulse irradiation with ultrahigh dose rate (0.5-3) x 106 Gy/minutes (pulse duration 65 x 10(-6) s). The difference averaged about 37% on total aberration frequency and 27% on the sum of dicentrics and centric rings. The influence of the dose rate and of the mixed gamma-neutron irradiation on the obtained results is discussed.