RESUMO
The nature and rate of endogenous autorosette formation were investigated in peripheral blood from cancer patients. Both neutrophils, monocytes and platelets were involved. The latter lysed red blood cells. Thrombotic autorosette levels rose as the number of lymphocytes was falling and metastases appeared.
Assuntos
Neoplasias/sangue , Neoplasias/imunologia , Formação de Roseta , Adulto , Idoso , Plaquetas/imunologia , Neoplasias da Mama/sangue , Neoplasias da Mama/imunologia , Neoplasias Esofágicas/sangue , Neoplasias Esofágicas/imunologia , Feminino , Humanos , Neoplasias Pulmonares/sangue , Neoplasias Pulmonares/imunologia , Masculino , Pessoa de Meia-Idade , Monócitos/imunologia , Neutrófilos/imunologia , Neoplasias Gástricas/sangue , Neoplasias Gástricas/imunologiaRESUMO
AIM: To study intensity of intravascular autorossette-formation (ARF) and its role in development of anemia in patients with chronic heart failure (CHF). MATERIAL AND METHODS: Blood smears (Romanovsky-Gimze stain) were obtained from 210 patients with CHF (functional class I-III) treated as indicated. Total number of autorossettes (AR) and AR with red cell lysis in them were calculated in the blood smears. RESULTS: The number of endogenic AR increases with higher functional class of CHF, duration of the disease, number of drugs. With increasing number of AR and AR with exocytic lysis, number of red cells and blood hemoglobin concentration lower. CONCLUSION: It is suggested that phenomenon of intravascular autorossette-formation is involved in pathogenesis of anemia in CHF patients and a cause of anemia may be much more complicated that it was thought initially.
Assuntos
Anemia/etiologia , Baixo Débito Cardíaco/complicações , Eritrócitos/patologia , Hemólise , Idoso , Capilares/patologia , Estudos de Casos e Controles , Contagem de Eritrócitos , Feminino , Hemoglobinas/análise , Humanos , Masculino , Monócitos/patologia , Neutrófilos/patologiaRESUMO
Endogenic auto-rosetting in peripheral blood was studied in workers exposed to paint-and-lacquer materials. Findings are increased numbers of general auto-rosettes and of auto-rosettes with extracellular RBC lysis (p < 0.001). That was associated with decrease of RBC and hemoglobin (p < 0.01).