RESUMO
The present paper focuses on the immunological and morphological aspects of extracorporal joining up of donor porcine spleen in the treatment of psoriasis. It has been ascertained that extracorporal joining up of donor porcine in the treatment of psoriasis makes for normalization of bodily immunologic reactivity leading to regression of psoriatic eruptions.
Assuntos
Circulação Cruzada/métodos , Hemoperfusão/métodos , Psoríase/terapia , Baço , Animais , Humanos , Neutrófilos/imunologia , Psoríase/imunologia , Baço/patologia , Suínos , Fatores de TempoRESUMO
Newly developed combined adsorbents, containing from 1 to 8 mg of thymic DNA per 1 g of the granulated or the fibrous carbonic matrix, demonstrated good biocompatibility and selectivity for DNA- and DNP-binding substances. In a group of 14 patients with severe psoriasis (uncontrol trial) a single hemoperfusion procedure through DNA-coated granulated synthetic carbons (perfusion volume was 2.5-3.1 L, sorbent quantity was 30 g) resulted in complete remission in 6 patients and in substantial improvement of clinical status in 6 other patients. A positive effect was observed in 4 patients during 7-11 months; in 8 patients it is being observed for more than 29-33 months. The double-blind tests in the group of patients subjected to hemoperfusion through the DNA-coated charcoal (27 people) and uncoated charcoal (9 people) showed the full-scale remission in 55.5% and 11.2% respectively. The authors believe that the DNA-coated activated carbons can be an effective therapeutic procedure for treatment of numerous immuno-dependent diseases and states associated with disorders in the kinetics of cell division.
Assuntos
Carbono/administração & dosagem , DNA/administração & dosagem , Hemoperfusão/métodos , Psoríase/tratamento farmacológico , Anticorpos Antinucleares/metabolismo , Sítios de Ligação , Materiais Biocompatíveis , Método Duplo-Cego , Feminino , Humanos , MasculinoRESUMO
The results of psoriasis sorption therapy (hemosorption (HS), plasmosorption (PS), hemosorption with exchanged plasma transfusion) are presented in this work. Indices of immunity and clinical efficiency of sorption therapy in 89 examined patients are studied. It was determined that sorption therapy possessed therapeutic efficiency with clinical forms of dermatosis, it promotes the normalization of immunological status indices, blood aggregation condition and microcirculation.
