RESUMO
BACKGROUND: Cardiac autonomic nervous system (ANS) dysfunction in Huntington's disease (HD) might affect both the sympathetic and parasympathetic branch of the ANS. RESULTS AND CONCLUSIONS: The pattern of linear heart rate variability we found in mid stage HD patients points towards a predominately reduced cardiovagal modulation compared with healthy subjects, which might influence HD patients' susceptibility for cardiovascular complications such as syncopes and cardiac arrhythmias.
Assuntos
Sistema Nervoso Autônomo/fisiopatologia , Frequência Cardíaca/fisiologia , Doença de Huntington/fisiopatologia , Postura/fisiologia , Adulto , Eletrocardiografia , Feminino , Coração/inervação , Coração/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Teste da Mesa Inclinada , Nervo Vago/fisiopatologiaRESUMO
To investigate the effect of depression and medication on the autonomic nervous system (ANS) we compared 25 patients suffering from depression with 72 matched control subjects (CON). From every patient three times ECG and non-invasive blood pressure were recorded in: acute non-mediated state (T1), medicated state (T2) and clinical recovered state (T3). Cardiac autonomic regulation was evaluated by linear and nonlinear analysis methods. The results show that non-medicated depressed patients differ significantly from CON (p0.05). In the medicated state considerably high significant differences between depressed patient and CON were found (p0.0001). After an 18 months follow-up a normalization of autonomic parameters was achieved in depressed patients. These results show that depression influences autonomic parameters significantly and that medical treated clinical recovered patients approximate to healthy controls in autonomic regulation.