[Effectiveness evaluation of the psychological support inclusion in the correction of pain syndrome in patients with movement disorders at the stage of medical rehabilitation using the virtual reality technology]. / Otsenka effektivnosti vklyucheniya psikhologicheskogo soprovozhdeniya s ispol'zovaniem tekhnologii virtual'noi real'nosti v korrektsiyu bolevogo sindroma u patsientov s narusheniyami dvigatel'nykh funktsii na etape meditsinskoi reabilitatsii.

OBJECTIVE: Evaluation of the comparative effectiveness of various methods of psychological support in the correction of pain syndrome in patients with degenerative-dystrophic diseases of big joints and spine in the process of medical rehabilitation. MATERIAL AND METHODS: In conditions of hospital, the 70 patients with degenerative-dystrophic diseases of the big joints and spine who received drug and non-drug treatment were examined. The dynamics of the psycho-emotional state, subjective assessment of well-being and pain was studied in three groups: the main group (24 patients) where the psycho-correction plan included classes with a medical psychologist using a high-tech VR tool - «Vive Focus Plus EEA virtual reality helmet¼. A comparison group (24 patients) who received a standard format of psychological support within the patient-centered approach. The control group (22 patients) where only psycho-diagnostic measures were carried out. The «Tamp Kinesiophobia Scale¼, «Visual Analogue Scale of Well-Being Evaluation¼, «McGill Pain Questionnaire¼ were used as diagnostic tools. When comparing the effects of the interventions the nociceptive or mixed nature of pain was taken into account. RESULTS AND CONCLUSION: It has been shown that psychological support improves the effectiveness of pain therapy while the inclusion of a high-tech VR tool in psycho-correctional programs is expedient for overcoming the fear of movement and pain of neuropathic and mixed genesis but ineffective for relieving nociceptive pain, i.e. pain where there is no psychological component.

[Adherence to treatment as a factor in increasing the effectiveness of psychological rehabilitation programs for stroke patients using augmented reality technology]. / Priverzhennost' k lecheniyu kak faktor povysheniya effektivnosti programm psikhologicheskoi reabilitatsii bol'nykh, perenesshikh insul't, s ispol'zovaniem tekhnologii dopolnennoi real'nosti.

PURPOSE OF THE STUDY: Studying the contribution of treatment adherence to the effective use of the Visual Medicine hardware and software complex (HSC) in the psychological rehabilitation of stroke patients. MATERIAL AND METHODS: The results of the use of APC in 81 patients undergoing a standard course of medical rehabilitation have been investigated (50 men and 31 women, average age 57.3±11.7 years). Compliance using the psycho-diagnostic questionnaire «Level of Compliance¼, which examines social, emotional and behavioral compliance; the state of higher mental functions (HMF) in dynamics by neuropsychological examination (tests for simultaneous and visual-spatial gnosis, kinesthetic, dynamic, spatial and constructive praxis) are studied. RESULTS AND CONCLUSION: It is shown that the use of a hardware-software complex helps to recover motor skills. However, the degree of positive dynamics of changes in the HMF state depends on the contribution of patient adherence to treatment, in particular, their «social compliance¼. It has been established that preventive diagnostics of social compliance at the average level, according to the questionnaire «Level of compliance¼, can be an indication for inclusion in the rehabilitation plan of training sessions with the program «Visual Medicine¼. Deviation towards low or high values signals the appointment of a medical psychologist consultation with the aim of further psychocorrectional work to achieve the optimal level of social compliance.

[Myofascial facial massage as a possible method of correction of psychoemotional states]. / Miofastsial'nyi massazh litsa kak vozmozhnyi metod korrektsii psikhoemotsional'nykh sostoyanii.

The work highlights the current problems of the relationship between the tonic activity of facial muscles and psychoemotional states. The frequency and severity of psychoemotional conditions and indicators of tonic activity of the facial muscles in 67 healthy women were studied. The currently known methods for the correction of psycho-emotional states based on the feedback mechanism are analyzed. The effectiveness of use of myofascial face massage as an instrument for the correction of psychological status was assessed. The influence of various massage techniques aimed at relaxing facial muscles on the psychoemotional state in the long term has been proved. The most effective tools for correcting muscle tone for the correction of psychoemotional states are proposed.

The stoichiometry of proton translocation through H+-ATPase of rat-liver mitochondria.

The ratio of the number of protons transported directly by H+-ATPase of intact mitochondria and that of the hydrolyzed ATP (the proton translocation quotient) is determined. A special kinetic method which makes possible determination of ATPase and H+-translocase activities in the same experiment has been used to estimate the proton translocation quotient for mitochondrial H+-ATPase. The quotient is found to be, on average, equal to 3.31 mol/mol. It is shown that the protonophore 3,5-di-tert-butyl-4-hydroxybenzylidenemalononitrile can greatly decrease the proton translocation quotient. This supports our assumption concerning a labile coupling between H+-translocase and ATPase in mitochondria [I. A. Gorskaya, K. F. Sholtz, S. A. Moreva, A. V. Kotelnikova (1979) Biochemistry (Engl. Transl. Biokhimiya) 44, 765-770]. A decrease in the translocation quotient in the presence of the protonophore is likely to be due to the ability of this uncoupler to take back the translocated protons into the mitochondrial matrix before their release into the medium. An electrostatic model of the molecular mechanism of H+-translocase and ATPase coupling in the H+-ATPase complex is discussed. The model is in agreement with the results obtained: transport of more than two protons per each hydrolyzed ATP molecule, and variable efficiency of the process.

A study of dependence of protein synthesis in mitochondria on the transmembrane potential.

1. Incorporation of [H3]leucine into the TCA insoluble fraction of rat liver mitochondria incubated in vitro is inhibited by uncouplers of oxidative phosphorylation. The inhibition is not correlated with the activation of mitochondrial ATPase. 2. Dependence of mitochondrial protein synthesis on the transmembrane potential is manifested in a wide range of K+ and Mg++ concentrations in the incubation media. 3. The inhibitory action of uncouplers shows a lag period equal to 5-7 minutes, this lag period however is not observed when the uncoupler is added to puromycin-treated mitochondria. 4. Dependence of mitochondrial protein synthesis on the transmembrane potential, which represents a property characteristic for the inner mitochondrial membrane suggests that mitochondrial ribosomes act in close contact with the mitochondrial membrane system.