[The risk-adaptive strategies of Hodgkin's lymphoma therapy].

Using of radiochemotherapy improves short-term and long-term results of treatment in patients with primary Hodgkin's lymphoma (HL) comparing with treatment by chemotherapy alone. The rates of 5-year, 10-year OS and DFS are 88%, 83% and 90%, 86% in case of radiochemotherapy, versus 73%, 66% and 72%, 68% using chemotherapy alone. The 5-year and 10-year OS, DFS estimates in treatment with ABVD are 84% and 83%, 75% and 74%; BEACOPP-baseline - 83% and 82%, 82% and 81% (p<0.05). At the same time ABVD chemotherapy develops less toxicity (p<0.001). The treatment with 6 cycles of ABVD is considered as the most appropriate in primary Hodgkin's lymphoma patients with extranodal lesions. Comparison of complications rate during chemotherapy with MOPP, ABVD, BEACOPP-baseline, BEACOPP-escalated reveals major hematologic toxicity and infectious complications rate in BEACOPP-escalated program (p<0,05). The age ≥45 years, hemoglobin <105g/l, B symptoms, fibrinogen >5g/l, involvement of 3 and more areas of lymph nodes, liver involvement, inguinal lymph nodes are defined by the multiple-factor analysis as adverse prognostic factors of patients with primary Hodgkin's lymphoma (HL) with extranodal lesions (p<0.05). Allocation of group of high risk is proved by correlation between survival and the Prognostic Score (PS). The 5-year and 10-year DFS, OS for patients with PS-0-2 estimates are 88% and 86%, 89% and 83%, for patients with PS-3-4 - 78% and 69%, 80% and 77%, for patients with PS-5-6 - 43% and 42%, 60% and 38% respectively (p<0.001).

[Spinal stroke in the acute myeloblast leucosis].

Data of literature on the frequency of the nervous system lesions in different variants of leucosis are analyzed. A case of a man with petechial skin rash and bruises on the body, gingival hemorrhage and general sickness is described in details. The hematologic tests revealed acute myeloblast leucosis. A lumbar puncture revealed blood in the cerebrospinal fluid and MRI showed an epidural hematoma in lumbar segments 3 and 4. At this level, the hematoma compressed the dural bag and roots of the horse tail with accompanying vessels (the radicular medullar artery and large radicular veins). A paracentetic removal of the hematoma with the decompression of spinal roots was carried out. The blasts in the cerebrospinal fluid and symptoms of the left facial nerve lesion allowed to diagnose neuroleucosis. This case presented the mixed pathogenesis of myeloischemia. The epidural hematoma compressed not only the roots of the horse tail but the accompanying vessels (arteries and veins). The venous outflow obstruction along radicular veins worsened the microcirculation in the cross-sectional area of the spinal cord. Complex polychemotherapy in the combination with neuroprotectors (cortexin, gliatiline), antiaggregants and vitamins is recommended.

Pulse wave sensors with improved noise immunity.

Reviewed in this article are the principle of operation and design features of the pulse wave sensors realizing the method of space-oriented differentiation for the noninvasive arterial pressure meters which can measure pressure during the physical tests of a patient. Disclosed are the test results and procedure for checking the pulse wave sensors using the nonstandard means of measurement.

[Automatic instrument for measuring blood pressure indirectly]. / Avtomaticheskii izmeritel' arterial'nogo davleniia kosvennym metodom.

The PPB-01 automatic blood pressure meter is recommended to ease the medical staff efforts, provide higher accuracy, and ability to further data input in the devices for automatic processing of biomedical information. Its functioning is based on variation of the slope of positive pulse-wave part. The meter features a high noise immunity and permits measurement at a moderate motor activity.

[Effect of immunization of pregnant women with staphylococcal toxoid on the immunologic status of the child]. / Vliianie immunizatsii stafilokokkovym anatoksinom beremennoi zhenshchiny na immunologicheskii status rebenka

A study was made of the effect of immunization of women during pregnancy of the immunological status of puerperants and their neonates, and also on the course of pregnancy in women and on development of a child aged under one year. Elevation of the IgG level in the blood serum, of the IgA -- in the milk of puerperants, and of the IgM -- in the blood serum of neonates, and also a marked increase in the antistaphylolysin titre in the mother and the neonate was revealed as a result of immunization. Clinical obervations showed such immunization to be harmless for the women, the neonate and the child the first year after birth. Immunization had a favourable effect on the state health of the children the first year after birth; this was expressed in a greater, in comparison with other children, resistance against infections diseases.