[The clinico-immunological characteristics of the treatment of patients with a severe course of bronchial asthma using the method of the extracorporeal incorporation of pig donor spleen]. / Kliniko-immunologicheskaia kharakteristika lecheniia bol'nykh s tiazhelym techeniem bronkhial'noi astmy metodom ékstrakorporal'nogo podkliucheniia donorskoi selezenki svin'i.

A comprehensive clinical-and-immunological evaluation was done of efficiency of treatment of patients with severe forms of bronchial asthma (BA) by hemosorption through donor porcine spleen, xenosorption (XS), in 63 patients. XS was found out to have a marked positive clinical effect manifested by a considerable decrease of frequency of asphyxiation bouts and amounts of inhalation broncholytics being taken within the first 24 hours after the procedure. By day 14 from the start of XS we succeeded in lowering the systemic corticosteroids maintenance dose on the average 2.5 times as little. Positive clinical dynamics correlated with positive immunologic changes which revealed themselves in normalization of numbers as well as functional activity of T-cells, rise in T-helpers, normalization of content of serum immunoglobulins A, M and G, with the parameters characterizing the system of phagocytosis approaching the norm, the processes of autoimmunization getting more attenuated.

[Recovery of immunological responsiveness in patients with bronchial asthma during nicotinamide treatment]. / Vosstanovlenie immunologicheskoi reaktivnosti u bol'nykh bronkhial'noiastmoi pri terapii nikotinamidom.

It has been found that among patients with bronchial asthma (BA) there are individuals with primary complete or partial lymphocytic resistance to glucocorticoid hormones (GC), which is apparently to be associated with cellular immunodeficiency and lower counts of young cortisol-sensitive cells in these patients. This condition may be aggravated with GC use and may appear as steroid dependence with all its clinical manifestations. It has been demonstrated that cellular steroid dependence may be either decreased or completely eliminated by special therapy aimed at enhancing lymphocytic sensitivity to hormones. Nicotinamide served as the drug of choice, which promoted the recovery of GC lymphocytic sensitivity, which may be attributed to the positive effects of the drug on the systemic immunity of BA patients.

[The comparative efficacy of hemosorption and xenosorption in bronchial asthma patients]. / Sravnitel'naiaéffektivnost' gemosorbtsii i ksenosorbtsii u bol'nykh bronkhial'noi astmoi.

The authors studied comparative clinical, immunologic, laboratory and functional effectiveness of hemosorption (HS) on charcoals and xenosorption (XS) on donor pig spleen in bronchial asthma patients. XS was administered in 60 patients, HS was applied to 91 patient. There was no significant difference in immunologic characteristics between the patient groups. However, XS had a more apparent positive influence on the external respiratory function, degree of allergy and unspecific inflammation, as well as on general clinical effectiveness.

[The clinico-immunological characteristics of bronchial asthma patients undergoing autologous ultraviolet blood irradiation]. / Kliniko-immunologicheskaia kharakteristika bol'nykh bronkhial'noi astmoi pri ul'trafioletovom obluchenii autokrovi.

Ultraviolet irradiation of blood studied in 201 patients with various forms of bronchial asthma proved to be the most effective in "aspirin" and infectious-allergic forms of the disease. Analysis of immunological changes showed that ultraviolet irradiation of blood brings to the norm content of IgG in serum, influence beneficially quantity and functional activity of T-lymphocytes, reduces auto-immunization and sensibilization to Streptococcus.

[The clinico-immunological efficacy of paspat and prodigiozan in the combined treatment of infectious-allergic bronchial asthma]. / Kliniko-immunologicheskaia éffektivnost' paspata i prodigiozana v kompleksnom lechenii infektsionno-allergicheskoi bronkhial'noi astmy.

64 patients with infectious-allergic bronchial asthma (IABA) were examined. 20 of them were co-administered paspat, 24 patients additionally received prodigiosan, 20 patients constituted control group and were given conventional treatment. Patients of all the groups were comparable in age, state of immunological reactivity of the body and severity of the disease. Immunomodulatory effect of the drugs, mainly of paspat, not only resulted in normalization of functional properties of granulocytes but also promoted liquidation of quantitative and functional IABA-conditioned immunodeficiency on the part of T- and B-lymphocytes, thus increasing effectiveness of the treatment in the whole.

[The clinico-immunological efficacy of triacort in bronchial asthma]. / Kliniko-immunologicheskaia éffektivnost' triakorta pri bronkhial'noi astme.

Efficacy of the home-made inhalant preparation "Tricort-aerosol" in 30 patients with moderate and severe bronchial asthma was assessed. Clinical, functional and immunological measures have been analyzed in the course of treatment with the drug. Administration of the drug in complex therapy was proved to be advisable in patients with different forms of bronchial asthma.

[The effect of vilozen on the immune status of bronchial asthma patients]. / Vliianie vilozena na immunnyi status bol'nykh bronkhial'noi astmoi.

An immunological study of 163 patients with different forms of bronchial asthma revealed a distinct disturbance of the cellular link of immunity in these patients. Vilosen (a native non-protein immunomodulator extracted from the thymus of animals) possessing a prevailing action on T-cells was used for correction of the immune disorders. It was found that vilosen proved effective in the complex treatment of patients with atopic associated forms of bronchial asthma.

[Methodology and effectiveness of bronchoscopy with polychromatic analysis in patients with pulmonary tuberculosis and sarcoidosis]. / Metodika i éffektivnost' bronkhoskopii s primeneniem polikhromaticheskogo analiza u bol'nykh tuberkulezom i sarkoidozom legkikh.

A procedure of polychromatic analysis (PA) was improved by using light filter occular attachments. In 154 patients, including those with pulmonary tuberculosis (101) and sarcoidosis (53), a diagnostic effectiveness of a traditional bronchoscopy is compared to that with PA, including morphoendoscopic comparison. As against traditional bronchoscopy, PA made it possible to find out in 34.8% an additional number of non-specific endobronchitis cases accompanying pulmonary tuberculosis, and at the same time to approach in 90.2% an endoscopic diagnosis to a pathomorphologic one. In several patients the authors managed to additionally distinguish by means of PA infiltrative bronchial tuberculosis of tuberous type. In pulmonary sarcoidosis the use of PA also allowed to increase a diagnostic effectiveness of the traditional bronchoscopy.

[Experimental pharmacodynamic study of rifampicin administered by various methods]. / Eksperimental'noe izuchenie farmakokinetiki rifampitsina pri razlichnykh metodakh vvedeniia.

The experimental study was performed on 80 male albino rats. The dose of rifampicin was 10 mg per 1 kg of the body weight. The highest rifampicin levels in the lung tissue were determined at all periods after intrabronchial administration of the drug. Thus, 2 hours after intrabronchial instillation of rifampicin its level in the lung tissue was 10--12 times higher than that after its enteral use. In 4 hours the antibiotic level decreased. Still, it remained 10 times higher than that after the enteral use. In 8 hours the level of rifampicin administered intrabronchially was almost the same as its maximum concentration in the lung tissue attained after the enteral use in 2 hours. By the 12th hour of the intrabronchial administration of rifampicin its concentration in the lung tissue markedly decreased. Still, it was 5--6 times higher than that after the enteral use. The rifampicin levels in the liver tissue after intrabronchial administration of the drug were at all periods much lower than those after the enteral use. The levels of rifampicin in the blood serum after its intrabronchial and enteral administration, as well as those in the liver tissue did not significantly differ.