[The results of the cytogenetic examination of children and adolescents living in radionuclide-contaminated regions of Kaluga Province]. / Rezul'taty tsitogeneticheskogo obsledovaniia detei i podrostkov, prozhivaiushchikh v zagriaznennykh radionuklidami raionakh Kaluzhskoi oblasti.

After the Chernobyl accident in a period from 1989 to 1992 blood samples were collected and analysed for chromosomal aberrations in lymphocytes from 490 children born and living continuously in two districts of Kaluga Province with radioactive contamination. The results of cytogenetic examinations show the frequency of unstable aberrations in children from Zhizdra District to be higher than that in children from Ulyanovo District and in the control group. No correlation was found between the thyroid absorbed doses ranging from 0 to 5 Gy and the aberration frequencies. No differences in chromosomal aberration yields were observed in children born before or after the Chernobyl accident. Repeat examinations of the same children cohorts revealed no significant changes with time in the level of unstable aberrations.

[The results of the cytogenetic examination of the inhabitants of population centers adjacent to the Semipalatinsk nuclear testing grounds (at the period of the work of the interdepartamental commission in 1989)]. / Rezul'taty tsitogeneticheskogo obsledovaniia zhitelei naselennykh punktov, prilegaiushchikh k Semipalatinskomu ispytatel'nomu iadernomu poligonu (v period raboty mezhvedomstvennoi komissii v 1989 g.).

Within the frames of activity of joint commission the cytogenetic studies of 98 persons from different areas of Semipalatinsk Province have been carried out in 1989. The studies revealed the higher level of chromosome aberrations in the settlements adjacent to firing ground. The possible connection of discovered cytogenetic lesions to the influence of radiation aftermath of ground and air nuclear weapon test is discussed.

[The results of the cytogenetic examination of children and adolescents living in radionuclide-contaminated regions of Bryansk Province]. / Rezul'taty tsitogeneticheskogo obsledovaniia detei i podrostkov, prozhivaiushchikh v zagriaznennykh radionuklidami raionakh Brianskoi oblasti.

The paper presents the data on cytogenetic studies of 663 children inhabited radionuclide contaminated territories of Bryansk Province. Statistically significant difference with control was observed only for the territory with the highest radioactive contamination level of 137Cs (1000 kBq/m2). For two other territories with lesser contamination (100 and 700 kBq/m2) the rate of chromosome aberrations is nearly the same and does not differ significantly from control one. No difference in the level of cytogenetic damage was discovered for children affected by radiation pre- or postnatally.

[A comparative study of the frequency of stable and unstable chromosome aberrations in the gamma irradiation of human lymphocytes in vitro]. / Sravnitel'noe issledovanie chastoty stabil'nykh i nestabil'nykh abberatsii khromosom pri gamma-obluchenii limfotsitov krovi cheloveka in vitro.

Comparative studies of the yield of stable and unstable chromosome aberrations have been carried out in human lymphocytes gamma irradiated in vitro within the doze range 0.1--1.0 Gy. It was observed that the yield of unstable chromosome aberrations (dicentrics and centric rings) is satisfactorily described for discovered dose range with linear-quadratic approximation. For stable chromosome aberrations in G-banded chromosome the dose response dependence was less expressed. The studies revealed non-random involvement of different chromosomes in translocations, and the most frequently involved are 1 and 13 chromosomes.

[Changes in the content of glucocorticoids in the plasma and tissues of rats in postnatal ontogeny]. / Izmenenie soderzhaniia gliukokortikoidov v plazme i tkaniakh krys v postnatal'nom ontogeneze.

The concentrations of two glucocorticoids (corticosterone and cortisol) were investigated in plasma and tissues of adult albino male rats and preweaning pups. An increase in corticosterone concentration in plasma and kidneys during maturation was shown. A steroid undistinguishable from cortisol in TLC, RIA and HPLC tests was detected in pups. A conclusion is made that cortisol takes part in hormonal regulation of immature rats.

[Modification of the intestinal syndrome using a hypoxic gas mixture under different conditions of animal irradiation]. / Modifitsirovanie kishechnogo sindroma s pomoshch'iu gazovoi gipoksicheskoi smesi v razlichnykh usloviiakh oblucheniia zhivotnykh.

In experiments on 1152 CBA mice and SHK colony and on 1180 Wistar rats it was demonstrated that a gas hypoxic mixture containing oxygen (10%) and nitrogen (90%) (GHM-10) reduced the intestinal syndrome of the acute radiation sickness in animals exposed to ionizing radiation at rest, during physical exercises, after radiation sickness endured earlier, after exposure to SHF, after fractionated irradiation, and after radiation-and-thermal damage.

[Cytogenetic effects induced by neutrons in human peripheral blood lymphocytes in vitro. I. Dose-effect relationship for different types of chromosome aberrations when exposed to neutrons with different energies]. / Tsitogeneticheskie éffekty, indutsiruemye neitronami v limfotsitakh perifericheskoi krovi cheloveka in vitro. Soobshchenie I. Zavisimost' éffekta ot dozy dlia raznykh tipov aberratsii khromosom pri vozdeistvii neitronov raznykh énergii.

Human lymphocytes were irradiated in vitro during G0 stage by graded doses of thermal neutrons and of neutrons with mean energy of 0.04; 0.09; 0.35; 0.85 and 14.7 MeV as well as by 60Co gamma-rays. The data were fitted to the linear and linear-quadratic relations. The neutrons of low and intermediate energies showed the linear dependence on the dose, 14.7 MeV neutrons and gamma-rays--a linear-quadratic one, whereas the data obtained with 0.85 MeV neutrons fitted well the both models. Terminal and interstitial deletions produced by both gamma-rays and neutrons showed different dependencies upon the dose. Some qualitative pecularities of aberration spectra were found in the experiments with neutrons as compared with the data on gamma-irradiation: the ratio of exchanges to fragments was greater, and aberrations of chromatid type were produced. The specially designed experiments and calculations showed that the last effect was not connected with induced radioactivity.

[Cytogenetic effects induced in vitro in human peripheral blood lymphocytes by neutrons. II. Relative biological effectiveness of neutrons having different energies]. / Tsi togeneticheskie éffekty, indutsiruemye neitronami v limfotsitakh perifericheskoi krovi cheloveka in vitro. Soobshchenie II. Otnositel'naia biologicheskaia éffektivnost' neitronov raznykh énergii.

Human lymphocytes were irradiated in vitro during Go stage by graded doses of thermal neutrons and neutrons having an average energy of 0.04; 0.09; 0.35; 0.85 and 14,7 MeV as well as by 60Co gamma rays, and RBE of neutrons relative to gamma-rays was calculated for the frequency of total and different types of aberrations. It was found that the RBE has the most value at the low doses and decreases when the exposition dose increases. 0.35 MeV neutrons have the maximum RBE in comparison with neutrons having other energies. When comparing the RBE values calculated for different types of chromosome aberrations, it was found out that dicentrics and dicentrics plus centric rings had more RBE than acentric aberrations (pair fragments and minutes).