RESUMO
This review is dedicated to one of the problems of liver transplantation and how to solve it. The incidence of complications after liver transplantation depends on ischemia-reperfusion injury of the graft. The global shortage of donor organs, using different technologies for conservation and graft function. This article describes the basic pathogenesis and proposed a new method for the prevention of ischemia reperfusion injury of the liver.
Assuntos
Hepatócitos , Transplante de Fígado , Fígado , Preservação de Órgãos/métodos , Traumatismo por Reperfusão , Animais , Hepatócitos/metabolismo , Hepatócitos/patologia , Humanos , Fígado/metabolismo , Fígado/patologia , Traumatismo por Reperfusão/mortalidade , Traumatismo por Reperfusão/patologia , Traumatismo por Reperfusão/prevenção & controleRESUMO
The article highlights the problem of the relationship of the intestinal microbiome person with metabolic syndrome. Changes in bacterial intestinal proportions in obesity captured the attention of scientists around the world, especially in relation to their effect on the metabolism. Increasing the proportion of Firmicutes and Actinobacteria and decrease of Bacteroidetes associated with increased levels of serum lipopolysaccharides, insulin resistance, weight gain, and other co-morbid manifestations of the metabolic syndrome. The mechanisms, underlying this interdisciplinary problems, actively studied to optimize the prevention and treatment of obesity and type 2 diabetes.
Assuntos
Intestinos/microbiologia , Síndrome Metabólica/microbiologia , Microbiota , Obesidade/microbiologia , Animais , Humanos , Síndrome Metabólica/terapia , Obesidade/terapia , Prebióticos , Probióticos/administração & dosagem , Probióticos/uso terapêuticoRESUMO
Experiments were performed in 18 male rats followed by a histological investigation of the obtained material. The application of the 30% solution of ethyl alcohol was proved to cause irreversible dystrophic alterations of nerve fibers in the gastric wall when injected subserously and there were no irreversible destructive alterations in other organ tissues. Results of treatment of 82 patients with perforated pyloro-duodenal ulcers after suturing the perforated opening in combination with chemical denervation of the gastric acid-producing zone with 30% solution of ethyl alcohol injected subserously were analyzed. Reliably decreased acid-proteolytic activity of the gastric body was found to result in stable remission and low percentage of recurrent diseases. The method can be recommended for wide practical use due to its simplicity and low percentage of recurrences of ulcer disease of the duodenum against the background of preserved helicobacteriosis of the stomach.
Assuntos
Ácido Gástrico/metabolismo , Úlcera Péptica Perfurada/terapia , Úlcera Gástrica/terapia , Estômago/inervação , Simpatectomia Química/métodos , Nervo Vago/efeitos dos fármacos , Animais , Modelos Animais de Doenças , Etanol , Feminino , Seguimentos , Mucosa Gástrica/metabolismo , Humanos , Masculino , Úlcera Péptica Perfurada/complicações , Úlcera Péptica Perfurada/metabolismo , Ratos , Ratos Wistar , Estudos Retrospectivos , Úlcera Gástrica/complicações , Úlcera Gástrica/metabolismo , Resultado do TratamentoRESUMO
The article presents the results of using the vagotomy of an acid-producing zone of a stomach by the method of chemical denervation. Subjects to the operation were 20 Wistar line male rats and 22 patients with perforating pyloroduodenal ulcers accompanied by cardio pathology. The simplicity, availability and low traumatism of the technique, in view of the low percent of a relapse of the pyloroduodenal ulcers, enable to recommend it for the treatment for the elderly patients with the heavy cardio pathology.
