A robust model of Stimulus-Specific Adaptation validated on neuromorphic hardware.

Stimulus-Specific Adaptation (SSA) to repetitive stimulation is a phenomenon that has been observed across many different species and in several brain sensory areas. It has been proposed as a computational mechanism, responsible for separating behaviorally relevant information from the continuous stream of sensory information. Although SSA can be induced and measured reliably in a wide variety of conditions, the network details and intracellular mechanisms giving rise to SSA still remain unclear. Recent computational studies proposed that SSA could be associated with a fast and synchronous neuronal firing phenomenon called Population Spikes (PS). Here, we test this hypothesis using a mean-field rate model and corroborate it using a neuromorphic hardware. As the neuromorphic circuits used in this study operate in real-time with biologically realistic time constants, they can reproduce the same dynamics observed in biological systems, together with the exploration of different connectivity schemes, with complete control of the system parameter settings. Besides, the hardware permits the iteration of multiple experiments over many trials, for extended amounts of time and without losing the networks and individual neural processes being studied. Following this "neuromorphic engineering" approach, we therefore study the PS hypothesis in a biophysically inspired recurrent networks of spiking neurons and evaluate the role of different linear and non-linear dynamic computational primitives such as spike-frequency adaptation or short-term depression (STD). We compare both the theoretical mean-field model of SSA and PS to previously obtained experimental results in the area of novelty detection and observe its behavior on its neuromorphic physical equivalent model. We show how the approach proposed can be extended to other computational neuroscience modelling efforts for understanding high-level phenomena in mechanistic models.

Robust neuromorphic coupled oscillators for adaptive pacemakers.

Neural coupled oscillators are a useful building block in numerous models and applications. They were analyzed extensively in theoretical studies and more recently in biologically realistic simulations of spiking neural networks. The advent of mixed-signal analog/digital neuromorphic electronic circuits provides new means for implementing neural coupled oscillators on compact, low-power, spiking neural network hardware platforms. However, their implementation on this noisy, low-precision and inhomogeneous computing substrate raises new challenges with regards to stability and controllability. In this work, we present a robust, spiking neural network model of neural coupled oscillators and validate it with an implementation on a mixed-signal neuromorphic processor. We demonstrate its robustness showing how to reliably control and modulate the oscillator's frequency and phase shift, despite the variability of the silicon synapse and neuron properties. We show how this ultra-low power neural processing system can be used to build an adaptive cardiac pacemaker modulating the heart rate with respect to the respiration phases and compare it with surface ECG and respiratory signal recordings from dogs at rest. The implementation of our model in neuromorphic electronic hardware shows its robustness on a highly variable substrate and extends the toolbox for applications requiring rhythmic outputs such as pacemakers.

Automatic detection of synaptic partners in a whole-brain Drosophila electron microscopy data set.

We develop an automatic method for synaptic partner identification in insect brains and use it to predict synaptic partners in a whole-brain electron microscopy dataset of the fruit fly. The predictions can be used to infer a connectivity graph with high accuracy, thus allowing fast identification of neural pathways. To facilitate circuit reconstruction using our results, we develop CIRCUITMAP, a user interface add-on for the circuit annotation tool CATMAID.

Discrimination of EMG Signals Using a Neuromorphic Implementation of a Spiking Neural Network.

An accurate description of muscular activity plays an important role in the clinical diagnosis and rehabilitation research. The electromyography (EMG) is the most used technique to make accurate descriptions of muscular activity. The EMG is associated with the electrical changes generated by the activity of the motor neurons. Typically, to decode the muscular activation during different movements, a large number of individual motor neurons are monitored simultaneously, producing large amounts of data to be transferred and processed by the computing devices. In this paper, we follow an alternative approach that can be deployed locally on the sensor side. We propose a neuromorphic implementation of a spiking neural network (SNN) to extract spatio-temporal information of EMG signals locally and classify hand gestures with very low power consumption. We present experimental results on the input data stream using a mixed-signal analog/digital neuromorphic processor. We performed a thorough investigation on the performance of the SNN implemented on the chip, by: first, calculating PCA on the activity of the silicon neurons at the input and the hidden layers to show how the network helps in separating the samples of different classes; second, performing classification of the data using state-of-the-art SVM and logistic regression methods and a hardware-friendly spike-based read-out. The traditional algorithm achieved a classification rate of [Formula: see text] and [Formula: see text], respectively, and the spiking learning method achieved [Formula: see text]. The power consumption of the SNN is [Formula: see text], showing the potential of this approach for ultra-low power processing.