RESUMO
In the current study we have presented the analyzed data of screening materials of type 2 diabetes patients aged 45 and above carried out in Kharkov (n=535) and Kharkov district villages (n=1052). It has been established, that the data of cohort people with normal body mass index were practically the same and accounted approximately one fourth of the analyzed patients. At the same time, it appeared that the patients living in the city were more susceptible to metabolic obesity (enlargement of abdominal fat tissue), arterial hypertension, myocardial infarction, insult and heavy family history. Metabolic obesity prevalent in city cohorts practically did not have any effect on the frequency of the above mentioned risk-factors. However, it definitely affected the cardio-vascular component in village cohorts.
Assuntos
Diabetes Mellitus Tipo 2/epidemiologia , Diabetes Mellitus Tipo 2/patologia , Hipertensão/epidemiologia , Obesidade/patologia , Tecido Adiposo/patologia , Idoso , Índice de Massa Corporal , Doenças Cardiovasculares/complicações , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/patologia , Diabetes Mellitus Tipo 2/etiologia , Feminino , Humanos , Hipertensão/complicações , Hipertensão/patologia , Masculino , Pessoa de Meia-Idade , Obesidade/complicações , Obesidade/epidemiologia , Fatores de RiscoAssuntos
Doenças do Sistema Nervoso Autônomo/diagnóstico , Neuropatias Diabéticas/diagnóstico , Eletromiografia/métodos , Doenças Urogenitais Femininas/diagnóstico , Diafragma da Pelve/fisiopatologia , Uretra/fisiopatologia , Adulto , Doenças do Sistema Nervoso Autônomo/complicações , Doenças do Sistema Nervoso Autônomo/fisiopatologia , Neuropatias Diabéticas/complicações , Neuropatias Diabéticas/fisiopatologia , Feminino , Doenças Urogenitais Femininas/etiologia , Doenças Urogenitais Femininas/fisiopatologia , Humanos , Pessoa de Meia-Idade , Reprodutibilidade dos TestesRESUMO
Polymorphism of PON-1 gene in 192 position of amino acid sequence of enzyme paraoxonase 1 was studied. For this research we have used the blood samples of 96 patients with T2DM and 123 healthy habitants of Kharkiv. Frequencies of alleles for the patients (pQ = 0,65, pR = 0,35) and the healthies (PQ = 0,70 and pR = 0,30) did not differentiate meaningfully. Distribution of the genotypes for healthy people does not correspond to Hardy-Weinberg equilibrium, the patients of T2DM have surplus of both homozygotes and shortage of heterozygotes. The risk of illness of T2DM for QQ homozygotes is 1,46-times higher and for QR heterozygotes is two times lower than on the average in the population (2%). The risk of illness of T2DM for RR homozygotes 1,86-times exceeds a middle population risk but is not significant.
Assuntos
Arildialquilfosfatase/genética , Diabetes Mellitus Tipo 2/genética , Polimorfismo de Nucleotídeo Único , Estudos de Casos e Controles , DNA/genética , Diabetes Mellitus Tipo 2/enzimologia , Eletroforese em Gel de Ágar , Feminino , Frequência do Gene , Predisposição Genética para Doença , Homozigoto , Humanos , Masculino , RiscoRESUMO
Genetic analysis was carried out on the material including clinic and genealogical data about 510 patients with type 2 Diabetes Mellitus, 445 Essential Hypertension individuals, 239 abdominal obesity persons and their 1st degree relatives. It has been shown that the Essential Hypertension and abdominal obesity distribution in the population and families can be described by means of a variants polygene model with essential influence of the major genes. Gene complexes of predisposition to obesity, Essential Hypertension and Type 2 Diabetes Mellitus are independent, however, their liabilities are covered.
Assuntos
Constituição Corporal , Predisposição Genética para Doença , Síndrome Metabólica/genética , Característica Quantitativa Herdável , Adulto , Constituição Corporal/genética , Diabetes Mellitus Tipo 2/epidemiologia , Diabetes Mellitus Tipo 2/genética , Feminino , Testes Genéticos , Genética Populacional , Humanos , Hipertensão/epidemiologia , Hipertensão/genética , Masculino , Síndrome Metabólica/epidemiologia , Obesidade Abdominal/epidemiologia , Obesidade Abdominal/genética , LinhagemRESUMO
A study made in 77 patients with different form of thyropathy revealed increased blood plasma and erythrocyte content of lipid peroxidation products, such as diene conjugates and TBA-active producers. The plasma chemiluminescence got more intense as well. Different mechanisms for the lipid peroxidation activation in patients presenting with thyroid hormone abundance or deficiency have been analyzed.
