RESUMO
A number of polyfluro-3,6-dihydro-2H-1,3,5-oxadiazines and polyfluoro-4H-1,3,5-oxadiazines was designed. Relationship between their chemical structure and in vitro activity was investigated. The highest activity against grampositive microorganisms was shown by N1,N6-bis-[2,2,6,6-tetrakis(trifluoromethyl)-3,6-dihydro-2H-1,3,5-oxadiazine-4-yl]-1,6-hexane diamine.
Assuntos
Antibacterianos/química , Antibacterianos/farmacologia , Bactérias Gram-Positivas/efeitos dos fármacos , Oxazinas/química , Oxazinas/farmacologia , Antibacterianos/síntese química , Estrutura Molecular , Oxazinas/síntese químicaRESUMO
A series of 1-(2-hydroxyethyl)- and 1-(3-hydroxyethyl)-3-substituted ureas and thioureas were synthesized. 1-(3-Hydroxyethyl)-3-acylthioureas were shown to be specific substrates for alcohol dehydrogenase in vitro.
Assuntos
Álcool Desidrogenase/química , Tioureia/análogos & derivados , Tioureia/química , Tioureia/síntese química , Ureia/química , Ureia/síntese química , Especificidade por SubstratoRESUMO
A series of uracil and theophyllin derivatives were synthesized. 4-Amino-1,3-dimethyl-5-nonanoylaminouracil displayed the most pronounced effect of the in vitro stimulation of the 2-deoxyglucose transport into hepatic rat cells.