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1.
Biomed Res Int ; 2016: 8459018, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27610382

RESUMO

Objective. Results of a device-training for nonambulatory individuals with thoracic and lumbar spinal cord injury (SCI) using a powered exoskeleton for technically assisted mobility with regard to the achieved level of control of the system after training, user satisfaction, and effects on quality of life (QoL). Methods. Observational single centre study with a 4-week to 5-week intensive inpatient device-training using a powered exoskeleton (ReWalk™). Results. All 7 individuals with SCI who commenced the device-training completed the course of training and achieved basic competences to use the system, that is, the ability to stand up, sit down, keep balance while standing, and walk indoors, at least with a close contact guard. User satisfaction with the system and device-training was documented for several aspects. The quality of life evaluation (SF-12v2™) indicated that the use of the powered exoskeleton can have positive effects on the perception of individuals with SCI regarding what they can achieve physically. Few adverse events were observed: minor skin lesions and irritations were observed; no falls occurred. Conclusions. The device-training for individuals with thoracic and lumbar SCI was effective and safe. All trained individuals achieved technically assisted mobility with the exoskeleton while still needing a close contact guard.


Assuntos
Exoesqueleto Energizado , Traumatismos da Medula Espinal/reabilitação , Adulto , Deambulação com Auxílio , Fontes de Energia Elétrica , Feminino , Humanos , Vértebras Lombares , Masculino , Pessoa de Meia-Idade , Educação de Pacientes como Assunto , Satisfação do Paciente , Estudos Prospectivos , Qualidade de Vida , Traumatismos da Medula Espinal/fisiopatologia , Vértebras Torácicas
2.
Ann Nutr Metab ; 60(2): 98-107, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22398912

RESUMO

INTRODUCTION: Oral iron as a supplement has been associated with adverse health consequences, especially in the context of young children with active malaria. A potential aggravating role of non-transferrin-bound iron (NTBI) has been proposed. MATERIAL AND METHODS: NTBI responses in both a fasting and post-oral iron dosing situation were related to serum iron concentration and ferritin status. Fasting and 1, 2, and 3 h postdose serum samples were obtained in conjunction with oral ferrous sulfate supplementation in aqueous solution of 0, 15, 30, 60, 120 and 240 mg Fe in a cohort of 8 healthy Guatemalan men over a 9-week metabolic protocol. Hemoglobin, serum ferritin, percent transferrin saturation, serum iron and NTBI were all measured. RESULTS: Circulating levels of serum iron and NTBI increased in a graded fashion in response to oral iron, with the relative increment for NTBI slightly greater than that of iron. Detectable NTBI was occasionally measured in fasting specimens, more frequently in subjects with high ferritin status. Post-iron NTBI responses, by contrast, were higher in normal-ferritin subjects in absolute terms, and rose with increasing postabsorptive serum iron responses. DISCUSSION: The appearance and response of circulating NTBI were consistent with recognized principles of iron regulation.


Assuntos
Suplementos Nutricionais , Hematínicos/farmacocinética , Ferro da Dieta/farmacocinética , Ferro/sangue , Adulto , Estudos de Coortes , Suplementos Nutricionais/efeitos adversos , Ferritinas/sangue , Compostos Ferrosos/administração & dosagem , Guatemala , Hematínicos/administração & dosagem , Hematínicos/efeitos adversos , Hemoglobinas/análise , Humanos , Absorção Intestinal , Ferro/metabolismo , Ferro da Dieta/administração & dosagem , Ferro da Dieta/efeitos adversos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Transferrina/metabolismo , Adulto Jovem
3.
Ann Nutr Metab ; 58(2): 158-66, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21654163

RESUMO

BACKGROUND/AIMS: Prohepcidin and the active form hepcidin-25 are two variants of the peptide hormone hepcidin for iron homoeostasis. Their regulatory role and usefulness as biomarkers of the iron status are uncertain. Our aim is to describe the intra-individual variance of serum and urinary hepcidin-25 and prohepcidin concentrations, the mutual associations of the 4 hepcidin formats, and their correspondence with iron status variables in male Guatemalan volunteers. METHODS: Eight healthy adult males provided serial samples of serum and urine without previous iron dosing over 6 intervals during a 9-week protocol period. Prohepcidin was assayed by a commercial enzyme immunoassay, and hepcidin-25 species in serum and urine were analysed by time-of-flight mass spectrometry after prior enrichment procedures. RESULTS: Serum hepcidin-25 levels correlated significantly with urinary hepcidin-25 concentrations, whereas serum and urinary prohepcidin were not associated with one another or with the homologous or converse formats for hepcidin-25. Serum ferritin and transferrin saturation were significantly correlated with serum hepcidin-25 concentrations, but not with urine hepcidin-25 or with either format of prohepcidin. CONCLUSION: Hepcidin-25 shows correspondence across biological fluids, and the background 'status' of hepcidin activation may be related to the host's iron stores, whereas prohepcidin concentrations showed no promise in this regard.


Assuntos
Peptídeos Catiônicos Antimicrobianos/sangue , Peptídeos Catiônicos Antimicrobianos/urina , Ferro/sangue , Estado Nutricional , Precursores de Proteínas/sangue , Precursores de Proteínas/urina , Adulto , Biomarcadores/sangue , Índice de Massa Corporal , Ferritinas/sangue , Guatemala , Hepcidinas , Humanos , Ferro/metabolismo , Deficiências de Ferro , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Fatores de Tempo , Transferrina/análise , Transferrina/metabolismo , Adulto Jovem
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