[Mathematical modeling of the fracture along the length of the femur diaphysis]. / Matematicheskoe modelirovanie pereloma po vsei dline diafiza bedrennoi kosti.

THE AIM OF THE STUDY: Was to establish a pattern of femur diaphysis fracture with impact force over the entire front surface in an increments of 25 mm. Transverse, oblique and comminuted femur fractures were studied as a result of mathematical modeling. The application of mathematical modeling using the finite element analysis made it possible to visualize and predict the tension arising in the transient material during the impact force of blunt object, as well as the features of fractures' morphology in different sections of femur diaphysis. Modelled data about the mechanism and morphology of femur fracture were confirmed by the results of original full-scale experiments.

[Forensic medical assessment of lidocaine and bupivacaine systemic toxicity]. / Sudebno-meditsinskaya otsenka sistemnoi toksichnosti lidokaina i bupivakaina.

THE AIM OF THE STUDY: Was to assess the lidocaine and bupivacaine systemic toxicity in forensic medical practice. The number of patients' clinical observations equal three with local anesthetic systemic toxicity (LAST) from the practice of forensic medical experts were studied, and a search of scientific publications for the last 5 years in PubMed database was conducted. The amount of publications, describing cases with LAST, equal four were selected. Differential diagnostic features between LAST and anaphylaxis were considered. The literature data about relationship between lidocaine's concentration in the blood serum and clinical features are shown. The forensic medical assessment of LAST is proposed.

[Mathematical modeling using finite element analysis in forensic medical examination]. / Matematicheskoe modelirovanie s pomoshch'yu konechno-elementnogo analiza v sudebno-meditsinskoi ekspertize.

The purpose of the work is to develop methods of mathematical modeling using finite element analysis in forensic medical examination. The stages of the methodology for solving problems of deformable body mechanics in forensic medicine are considered, which allows to reliably establish the possibility of formation and morphology of damage under specific conditions and circumstances, to focus the researcher's attention on problem points when creating and evaluating the model. The use of simplified models of the human body makes the expert's conclusion more reasonable, which increases the confidence of law enforcement agencies in the activities of the forensic medical expert service and allows for a new look at solving the problems of forensic medicine and forensic medical examination.

[Mathematical modeling of femoral diaphyseal fracture at an acute angle]. / Matematicheskoe modelirovanie pereloma diafiza bedrennoi kosti pod ostrym uglom.

The aim of the work is to establish the regularity of the formation femoral diaphysis fracture under an impact action on the anterior surface of the femur at an acute angle. As a result of mathematical modeling, transverse and short oblique, comminuted fractures of the femoral diaphysis were studied. Application of mathematical modeling with final element analysis made it possible to visualize and predict the stresses arising in the trace-perceiving material under the impact action of a blunt solid object. The data obtained in modeling of the mechanism and morphology of the femoral diaphysis fracture are confirmed by the results of the original full-scale experiments. Absence of experiments and practical observations of femoral fractures with the above described conditions does not enable us to fully validate the mathematical model of femoral fracture and indicates the need for scientific research on biomannequins.

Baclofen (fun drug) and ethanol combined poisoning in humans: A histopathology and morphometry model.

BACKGROUND: - This study intends to address the scarcity of data regarding the pathogenesis of Baclofen poisoning in humans, which has seen a recent increase, worldwide, especially amongst the young people. Another reason for the conduction of this study was lack of the substantial data about the histo-pathological findings of lungs, in synergistic toxicity of Baclofen with Ethanol, in-spite of it being very common in humans, and both being respiratory depressant with similar mechanism of action. PURPOSE: - The authors aimed to understand the pathogenesis of fatal poisonings in humans due to Baclofen in combination with Ethanol via an animal research model. The enhancement of the overall scientific literature by extending research along the lines of the handful studies available in this regard was another adjunct goal of the study. MATERIAL AND METHODS: Fifteen Wistar rats were divided into control and test group of five and ten subjects respectively. The test group was further divided into two sub-groups of five each, with Baclofen administered to one, and it in conjunction with Ethanol to the other, in lowest dosages adjusted for the humans. Rats in both the groups were euthanized by dislocation of the cervical vertebrae for the histopathology examination. RESULTS: Capillary and venous plethora, hemorrhages in the inter-alveolar septi, hemorrhages into the alveoli and sludging was seen in the 1st sub-group. The plethora of venules, capillaries and arterioles, with sludging by the WBC (white blood corpuscle) infiltrates was seen in the 2nd sub-group. Desquamation of the ciliated epithelium and edematous thickening of the intra-alveolar septi, along with features suggestive of the peri-vascular edema was seen in the 2nd sub-group. The morphometric analysis of the micro vessels showed a significantly higher value of the arteriolar diameter in the 2nd sub-group, in comparison to 1st, but the venular diameter in the two sub-groups did not differ to any extent.

Forensic pathological characteristics of explosion trauma in confined space terrorist mass fatalities classified with a 3-dimensional model.

BACKGROUND: Explosion fatalities are the severest type of violent crimes. These involve the use of explosive devices in terrorist like activities in confined spaces in civilian or military settings, with mass number of people present all around. A stark dearth of literature for the forensic interpretation of such catastrophes is astonishing. PURPOSE: Characterization of the pattern of the multitude of injuries in explosions in confined spaces as guide for investigations and growth of literature on this entity. METHODOLOGY: A review of the archives of the forensic examinations of mass fatalities due to an explosion in a metro car was undertaken. It was combined with the reconstruction of the events by developing a three-dimensional model of this incident that involved seventeen fatalities. RESULTS: All the decedents showed differential pattern of fatal injuries under the influence of damaging explosion factors (DEFs). The causative forces were characterized as gas-detonation (in all the cases), damaging effect by shock waves (59% of the cases), and impact of fragmentation and collision of the body (thrown off) with nearby objects. Traumatic effect due to shrapnel as well as blunt force was noted in 82% of the cases. Gross destruction of head due to combined effect of gas-detonation and fragmentation was seen in 29% of the cases. CONCLUSION: An interpretation of the nature and pattern of injuries in confined space explosions can help to estimate the location of deceased/s with respect to the epicenter and the type of DEFs.

[The mathematical modeling of the injurious impact on the tibial bone for the evaluation of the conditions leading to its fracture]. / Matematicheskoe modelirovanie travmiruiushchego vozdeistviia na bol'shebertsovuiu kost' dlia otsenki uslovii obrazovaniia pereloma.

We have undertaken the mathematical modeling of the process associated with the destruction of the diaphyseal and proximal epiphyseal parts of the tibial bone by means of the finite element analysis. The main emphasis was laid on the elucidation of the topography of force stresses in the model bone. It was shown that loading the upper third of the bone either along its axis or perpendicular to the surface (i.e. in the region formed largely by the cancellous tissue) results in the depressed fracture at the site of the impact. Loading of the mid-third region of the bone (characterized by the predominance of the compact tissue) under the same conditions led to the transverse fracture originating from the side opposite to the impact application site.

[Simulation of the mechanisms of formation of stab and slash wounds by the finite element method].

The application of finite element analysis for the simulation of penetration of a blade with the broken tip through the skin made it possible to visualize the process of its destruction and to assess the trace-forming properties of the blade. The findings obtained in the present study confirm the results of previous attempts to consider the damage to tissues by pointed objects in terms of theoretical mechanics based on the theory of material cutting.

[Forensic medical evaluation of stab-incised wounds caused by knives with point defects].

The present experimental study allowed to characterize specific signs of stab-incised wounds caused by knives with operational point defects. Diagnostic coefficients calculated for these macro- and microscopic features facilitate differential diagnostics of the injuries and make it possible to identify a concrete stabbing/cutting weapon with which the wound was inflicted..