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1.
Psychophysiology ; 60(9): e14315, 2023 09.
Artigo em Inglês | MEDLINE | ID: mdl-37186319

RESUMO

Individuals with grandiose narcissism exhibit enhanced antagonism and a defensive pattern of discordance between their emotional and physiological reactions to self-threatening evaluations. Although theoretical perspectives link narcissistic defensiveness to negative emotions, empirical evidence linking grandiose narcissism to emotional reactivity remains mixed. The current study used self-reported affect, electrocardiography, and facial electromyography (fEMG) to examine whether people scoring high in grandiose narcissism show amplified physiological and self-reported emotional reactivity to negative social evaluation. Following two challenging cognitive tasks, participants received negative and neutral feedback in a face-to-face evaluation situation. Receiving negative feedback decreased self-reported positive affect and dominance, slowed heart rate, and amplified fEMG activity related to frowning and eye constriction. Although self-reported emotional reactions were unrelated to grandiose narcissism, fEMG activity associated with negative affect was significantly enhanced by grandiose narcissism. In conclusion, individuals with higher levels of grandiose narcissism may not be willing to report overt emotional reactivity to self-threatening feedback, but physiological responses "beneath their thin skin" reveal amplified threat-related facial muscle activity suggestive of a negative emotional state.


Assuntos
Narcissus , Humanos , Músculos Faciais , Emoções , Transtornos do Humor , Narcisismo
2.
Front Psychol ; 13: 993663, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36300061

RESUMO

Continued interest in the distinction between grandiose narcissism, vulnerable narcissism and the fluctuation between grandiose and vulnerable states has expanded the repertoire of self-report instruments. The present study examined the psychometric properties of four brief narcissism measures [the Narcissistic Personality Inventory-13 (NPI-13), Hypersensitive Narcissism Scale (HSNS), Super-Brief Pathological Narcissism Inventory (SB-PNI), and the g-FLUX] in a Finnish sample of university students. Confirmatory factor analyses supported the reliability of the NPI-13, g-FLUX, SB-PNI Vulnerability, and two HSNS subfactors (Oversensitivity and Egocentrism). Tests of measurement invariance indicated the NPI-13, SB-PNI Vulnerability, HSNS Oversensitivity, and the g-FLUX perform similarly between males and females and are generally similar between individuals in younger and older age groups. Construct and predictive validity were evaluated by examining relations between narcissism measures and relevant criteria including psychopathology symptoms, self-esteem, well-being, five factor traits, and empathy. Results supported the construct validity of all four measures, while correlational profiles highlighted the convergence between the g-FLUX and measures of both grandiosity and vulnerability. The NPI-13 was most predictive of NPD symptoms, whereas vulnerable narcissism measures were most predictive of psychopathology. Results further establish the psychometric properties of the NPI-13, SB-PNI Vulnerability, HSNS Oversensitivity, Egocentrism, and provide new validation of the g-FLUX.

3.
Psychol Assess ; 30(7): 984-990, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29792507

RESUMO

Despite a growing interest in the use of self-report measures of narcissism among student, community, and clinical samples, the research on narcissism in prison samples is sparse, despite elevated rates of narcissism in these samples. The current study examined the relations between commonly used measures of grandiose narcissism (Narcissistic Personality Inventory-13 [NPI-13]), vulnerable narcissism (Hypersensitive Narcissism Scale [HSNS]), and narcissistic personality disorder (NPD; Personality Diagnostic Questionnaire [PDQ]) in a sample of adult male offenders (N = 179). The NPI-13 and PDQ NPD scales overlapped substantially with one another and manifested similar empirical profiles (rICC = .81), with both being substantially correlated with interview-based symptoms of NPD, entitlement, psychopathy, and externalizing behaviors. Conversely, the HSNS manifested more limited relations with other measures of NPD and related traits (e.g., entitlement), as well as externalizing behaviors, and was more strongly related to internalizing symptoms. Consistent with previous work, NPD appears to be a blend of grandiose and vulnerable narcissism as the PDQ's empirical profile overlapped with that of the HSNS (rICC = .51), which was not true for the NPI-13 (rICC = .18). Analyses of the incremental validity of the 3 measures suggested that the NPI-13 was particularly successful in accounting for unique variance in these relevant criteria. These results underscore the benefit of utilizing multiple measures to distinguish empirical correlates of grandiose narcissism, vulnerable narcissism, and NPD. (PsycINFO Database Record


Assuntos
Criminosos/psicologia , Narcisismo , Transtornos da Personalidade/diagnóstico , Transtornos da Personalidade/psicologia , Inventário de Personalidade/estatística & dados numéricos , Autorrelato/estatística & dados numéricos , Adolescente , Adulto , Criminosos/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Prisioneiros/psicologia , Prisioneiros/estatística & dados numéricos , Inquéritos e Questionários , Wisconsin , Adulto Jovem
5.
J Allergy Clin Immunol Pract ; 6(1): 126-131, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-28634104

RESUMO

BACKGROUND: We developed and validated NLP-PAC, a natural language processing (NLP) algorithm based on predetermined asthma criteria (PAC) for asthma ascertainment using electronic health records at Mayo Clinic. OBJECTIVE: To adapt NLP-PAC in a different health care setting, Sanford Children Hospital, by assessing its external validity. METHODS: The study was designed as a retrospective cohort study that used a random sample of 2011-2012 Sanford Birth cohort (n = 595). Manual chart review was performed on the cohort for asthma ascertainment on the basis of the PAC. We then used half of the cohort as a training cohort (n = 298) and the other half as a blind test cohort to evaluate the adapted NLP-PAC algorithm. Association of known asthma-related risk factors with the Sanford-NLP algorithm-driven asthma ascertainment was tested. RESULTS: Among the eligible test cohort (n = 297), 160 (53%) were males, 268 (90%) white, and the median age was 2.3 years (range, 1.5-3.1 years). NLP-PAC, after adaptation, and the human abstractor identified 74 (25%) and 72 (24%) subjects, respectively, with 66 subjects identified by both approaches. Sensitivity, specificity, positive predictive value, and negative predictive value for the NLP algorithm in predicting asthma status were 92%, 96%, 89%, and 97%, respectively. The known risk factors for asthma identified by NLP (eg, smoking history) were similar to the ones identified by manual chart review. CONCLUSIONS: Successful implementation of NLP-PAC for asthma ascertainment in 2 different practice settings demonstrates the feasibility of automated asthma ascertainment leveraging electronic health record data with a potential to enable large-scale, multisite asthma studies to improve asthma care and research.


Assuntos
Algoritmos , Asma/diagnóstico , Atenção à Saúde , Processamento de Linguagem Natural , Pré-Escolar , Fumar Cigarros/efeitos adversos , Estudos de Coortes , Registros Eletrônicos de Saúde , Estudos de Viabilidade , Feminino , Humanos , Lactente , Masculino , Valor Preditivo dos Testes , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Sensibilidade e Especificidade
6.
J Am Med Inform Assoc ; 25(3): 353-359, 2018 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-29202185

RESUMO

OBJECTIVE: To assess clinical documentation variations across health care institutions using different electronic medical record systems and investigate how they affect natural language processing (NLP) system portability. MATERIALS AND METHODS: Birth cohorts from Mayo Clinic and Sanford Children's Hospital (SCH) were used in this study (n = 298 for each). Documentation variations regarding asthma between the 2 cohorts were examined in various aspects: (1) overall corpus at the word level (ie, lexical variation), (2) topics and asthma-related concepts (ie, semantic variation), and (3) clinical note types (ie, process variation). We compared those statistics and explored NLP system portability for asthma ascertainment in 2 stages: prototype and refinement. RESULTS: There exist notable lexical variations (word-level similarity = 0.669) and process variations (differences in major note types containing asthma-related concepts). However, semantic-level corpora were relatively homogeneous (topic similarity = 0.944, asthma-related concept similarity = 0.971). The NLP system for asthma ascertainment had an F-score of 0.937 at Mayo, and produced 0.813 (prototype) and 0.908 (refinement) when applied at SCH. DISCUSSION: The criteria for asthma ascertainment are largely dependent on asthma-related concepts. Therefore, we believe that semantic similarity is important to estimate NLP system portability. As the Mayo Clinic and SCH corpora were relatively homogeneous at a semantic level, the NLP system, developed at Mayo Clinic, was imported to SCH successfully with proper adjustments to deal with the intrinsic corpus heterogeneity.

7.
Child Psychiatry Hum Dev ; 48(6): 967-982, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-28315981

RESUMO

Psychopathic traits are a manifestation of a personality pathology that comprises a core affective-interpersonal dysfunction (callous-unemotional traits) and an impulsive-antisocial behavioral component. Of particular importance, psychopathic traits are associated with the perpetration of some of the most severe acts of violence, and they appear to indicate a subset of youth at risk for earlier onset, greater frequency, and persistence of violent offending. Although these youth represent a minority of the population, they commit a significant proportion of the violence in the general community. In our review, we highlight evidence of a unique neurobiological predisposition that underlies the core affective deficits and describe contemporary accounts for the developmental processes leading to the antisocial behavior associated with psychopathy. Current evidence suggests that, for this subset of youth, the structure and function of neural circuitry supporting emotion processing, reward learning, decision making, and the development of emotion related to empathy may be crucial to understanding why they are at risk for violence. In particular, a reward dominant pattern of neurobehavioral conditioning may explain how these youth progress to some of the most severe and persistent forms of violence. However, this pattern of conditioning may also be essential to the primary prevention of such deleterious behavior. We suspect that effective strategies to prevent such violence may ultimately be informed by understanding these affective and motivational mechanisms.


Assuntos
Transtorno da Personalidade Antissocial/psicologia , Recompensa , Violência/psicologia , Adolescente , Agressão/psicologia , Criminosos , Emoções , Empatia , Humanos , Comportamento Impulsivo
8.
Ann Epidemiol ; 26(7): 455-460, 2016 07.
Artigo em Inglês | MEDLINE | ID: mdl-27266369

RESUMO

PURPOSE: We aimed to assess whether smoking status among individuals in late adolescence (19-22 years) with asthma was associated with socioeconomic status (SES) defined by HOUSES, an individual-housing-based SES measure. METHODS: A population-based cross-sectional study was conducted among the 1988-1989 Olmsted County, Minnesota Birth Cohort, with physician-diagnosed asthma and that lived in the community during the study period (November 1, 2008-October 31, 2012). Using a z score for housing value, actual square footage, and numbers of bedrooms and bathrooms, HOUSES was formulated and categorized into quartiles. Smoking status (both current and past smoker) was compared among subjects with different SES as measured by HOUSES using logistic regression, adjusting for age and sex. RESULTS: Among 289 eligible subjects, 287 (99%) were successfully geo-coded to real property data for HOUSES. Of the 257 subjects whose smoke exposure was recorded, 70 (27%) had a history of smoking (either past or current). An inverse association was observed between HOUSES and smoking status after accounting for age, gender, and General Medical Examination status (adjusted OR = 0.39, 95% CI = 0.18-0.87 for comparing highest vs. lowest HOUSES in quartile; overall P = .02). CONCLUSIONS: A significant proportion of individuals with asthma in late adolescence was smokers during the study period, disproportionally affecting those with lower SES.


Assuntos
Asma/epidemiologia , Fumar/epidemiologia , Classe Social , Poluição por Fumaça de Tabaco/estatística & dados numéricos , Adolescente , Idade de Início , Asma/diagnóstico , Estudos Transversais , Escolaridade , Características da Família , Feminino , Humanos , Incidência , Renda , Modelos Logísticos , Masculino , Minnesota/epidemiologia , Razão de Chances , Estudos Retrospectivos , Medição de Risco , Fumar/efeitos adversos , Poluição por Fumaça de Tabaco/efeitos adversos , Adulto Jovem
9.
Cogn Affect Behav Neurosci ; 16(5): 779-88, 2016 10.
Artigo em Inglês | MEDLINE | ID: mdl-27225501

RESUMO

Psychopathic individuals are prone to act on urges without adequate consideration of future consequences or the rights of other individuals. One interpretation of this behavior is that it reflects abnormal selective attention (i.e., a failure to process information that is incongruent with their primary focus of attention; Hiatt, Schmitt, & Newman, Neuropsychology, 18, 50-59, 2004). Unfortunately, it is unclear whether this selective attention abnormality reflects top-down endogenous influences, such as the strength or specificity of attention focus (i.e., top-down set) apart from other, more exogenous (bottom-up), effects on attention. To explore this question, we used an early visual event-related potential (N2pc) in combination with a modified visual search task designed to assess the effect of early endogenous (i.e., top-down) attention on the processing of set-congruent information. The task was administered to a sample of 70 incarcerated adult males, who were assigned to high, intermediate, and low psychopathy groups using Hare's Psychopathy Checklist-Revised (Hare, 2003). Based on the assumption that their failure to process set-incongruent information reflects the exaggerated effects of endogenous attention, we predicted that participants with high psychopathy scores would show an exaggerated N2pc response to set-congruent information. The results supported the hypothesis and provide novel electrophysiological evidence that psychopathy is associated with exaggerated endogenous attention effects during early stages of processing. Further research is needed to examine the implications of this finding for the well-established failure of psychopathic individuals to process set-incongruent information and inhibit inappropriate responses.


Assuntos
Transtorno da Personalidade Antissocial/fisiopatologia , Transtorno da Personalidade Antissocial/psicologia , Atenção/fisiologia , Encéfalo/fisiopatologia , Potenciais Evocados Visuais , Adulto , Criminosos , Eletroencefalografia , Humanos , Entrevista Psicológica , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Estimulação Luminosa , Escalas de Graduação Psiquiátrica , Tempo de Reação , Fatores de Tempo , Adulto Jovem
10.
Mayo Clin Proc ; 91(5): 612-22, 2016 05.
Artigo em Inglês | MEDLINE | ID: mdl-27068669

RESUMO

OBJECTIVE: To characterize health disparities in common chronic diseases among adults by socioeconomic status (SES) and ethnicity in a mixed rural-urban community of the United States. PATIENTS AND METHODS: We conducted a cross-sectional study to assess the association of the prevalence of the 5 most burdensome chronic diseases in adults with SES and ethnicity and their interaction. The Rochester Epidemiology Project medical records linkage system was used to identify the prevalence of coronary heart disease, asthma, diabetes, hypertension, and mood disorder using International Classification of Diseases, Ninth Revision codes recorded from January 1, 2005, through December 31, 2009, among all adult residents of Olmsted County, Minnesota, on April 1, 2009. For SES measurements, an individual HOUsing-based index of SocioEconomic Status (HOUSES) derived from real property data was used. Logistic regression models were used to examine the association of the prevalence of chronic diseases with ethnicity and HOUSES score and their interaction. RESULTS: We identified 88,010 eligible adults with HOUSES scores available, of whom 48,086 (54.6%) were female and 80,699 (91.7%) were non-Hispanic white; the median (interquartile range) age was 45 years (30-58 years). Overall and in the subgroup of non-Hispanic whites, SES measured by HOUSES was inversely associated with the prevalence of all 5 chronic diseases independent of age, sex, and ethnicity (P<.001). While an association of ethnicity with disease prevalence was observed for all the chronic diseases, SES modified the effect of ethnicity for clinically less overt conditions (interaction P<.05 for each condition [diabetes, hypertension, and mood disorder]) but not for coronary heart disease, a clinically more overt condition. CONCLUSION: In a mixed rural-urban setting with a predominantly non-Hispanic white population, health disparities in chronic diseases still exist across SES. The extent to which SES modifies the effect of ethnicity on the risk of chronic diseases may depend on the nature of the disease.


Assuntos
Doença Crônica/epidemiologia , Disparidades nos Níveis de Saúde , Classe Social , Adolescente , Adulto , Negro ou Afro-Americano/estatística & dados numéricos , Idoso , Asiático/estatística & dados numéricos , Doença Crônica/economia , Doença Crônica/etnologia , Estudos Transversais , Feminino , Mapeamento Geográfico , Hispânico ou Latino/estatística & dados numéricos , Humanos , Classificação Internacional de Doenças , Modelos Logísticos , Masculino , Registro Médico Coordenado , Prontuários Médicos , Pessoa de Meia-Idade , Minnesota/epidemiologia , Prevalência , Características de Residência/classificação , População Branca/estatística & dados numéricos , Adulto Jovem
11.
BMJ Open ; 5(4): e006469, 2015 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-25926142

RESUMO

OBJECTIVES: To assess whether HOUSES (HOUsing-based index of socioeconomic status (SES)) is associated with risk of and mortality after rheumatoid arthritis (RA). DESIGN: We conducted a population-based case-control study which enrolled population-based RA cases and their controls without RA. SETTING: The study was performed in Olmsted County, Minnesota. PARTICIPANTS: Study participants were all residents of Olmsted County, Minnesota, with RA identified using the 1987 American College of Rheumatology criteria for RA from 1 January 1988, to 31 December 2007, using the auspices of the Rochester Epidemiology Project. For each patient with RA, one control was randomly selected from Olmsted County residents of similar age and gender without RA. PRIMARY AND SECONDARY OUTCOME MEASURE: The disease status was RA cases and their matched controls in relation to HOUSES as an exposure. As a secondary aim, post-RA mortality among only RA cases was an outcome event. The associations of SES measured by HOUSES with the study outcomes were assessed using logistic regression and Cox models. HOUSES, as a composite index, was formulated based on a summed z-score for housing value, square footage and number of bedrooms and bathrooms. RESULTS: Of the eligible 604 participants, 418 (69%) were female; the mean age was 56±15.6 years. Lower SES, as measured by HOUSES, was associated with the risk of developing RA (0.5±3.8 for controls vs -0.2±3.1 for RA cases, p=0.003), adjusting for age, gender, calendar year of RA index date, smoking status and BMI. The lowest quartile of HOUSES was significantly associated with increased post-RA mortality compared to higher quartiles of HOUSES (HR 1.74; 95% CI 1.10 to 2.74; p=0.017) in multivariate analysis. CONCLUSIONS: Lower SES, as measured by HOUSES, is associated with increased risk of RA and mortality after RA. HOUSES may be a useful tool for health disparities research concerning rheumatological outcomes when conventional SES measures are unavailable.


Assuntos
Artrite Reumatoide/mortalidade , Habitação/estatística & dados numéricos , Adulto , Idoso , Estudos de Casos e Controles , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Minnesota/epidemiologia , Modelos de Riscos Proporcionais , Fatores de Risco , Fatores Socioeconômicos
12.
Personal Disord ; 6(1): 12-21, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25330183

RESUMO

Narcissistic personality disorder is associated with distinguishing traits including self-enhancement, arrogance, and intense reactivity to ego threat. Theoretical accounts of narcissism suggest these heterogeneous behaviors reflect a defensive motivational style that functions to both uphold and protect the self-concept. However, the notion that narcissism can be characterized by grandiose and vulnerable dimensions raises the possibility that these diverse behaviors represent distinct expressions of narcissistic defensiveness. The present study examined whether both dimensions exhibit a general defensive style marked by selective attention to evaluative stimuli or are differentially associated with selective attention to positive and negative information, respectively. Using a dot probe task consisting of valenced and neutral trait adjectives, we evaluated these hypotheses in a group of male offenders. Results indicated that vulnerable narcissism was associated with attention biases for both positive and negative stimuli, though the dimension was further distinguished by disengagement difficulties and a greater recognition memory bias in response to negative words. Conversely, grandiose narcissism was associated with increased accuracy when attending to positive stimuli and directing attention away from negative stimuli. Overall, these findings suggest narcissistic individuals share motivated selective attention in response to evaluative stimuli, while simultaneously highlighting important phenotypic differences between grandiose and vulnerable dimensions.


Assuntos
Atenção/fisiologia , Criminosos/psicologia , Narcisismo , Transtornos da Personalidade/fisiopatologia , Adulto , Humanos , Masculino , Prisioneiros/psicologia
13.
Int J Environ Res Public Health ; 11(11): 11597-615, 2014 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-25396769

RESUMO

BACKGROUND: To assess whether the individual housing-based socioeconomic status (SES) measure termed HOUSES was associated with post-myocardial infarction (MI) mortality. METHODS: The study was designed as a population-based cohort study, which compared post-MI mortality among Olmsted County, Minnesota, USA, residents with different SES as measured by HOUSES using Cox proportional hazards models. Subjects' addresses at index date of MI were geocoded to real property data to formulate HOUSES (a z-score for housing value, square footage, and numbers of bedrooms and bathrooms). Educational levels were used as a comparison for the HOUSES index. RESULTS: 637 of the 696 eligible patients with MI (92%) were successfully geocoded to real property data. Post-MI survival rates were 60% (50-72), 78% (71-85), 72% (60-87), and 87% (81-93) at 2 years for patients in the first (the lowest SES), second, third, and fourth quartiles of HOUSES, respectively (p < 0.001). HOUSES was associated with post-MI all-cause mortality, controlling for all variables except age and comorbidity (p = 0.036) but was not significant after adjusting for age and comorbidity (p = 0.24). CONCLUSIONS: Although HOUSES is associated with post-MI mortality, the differential mortality rates by HOUSES were primarily accounted for by age and comorbid conditions. HOUSES may be useful for health disparities research concerning cardiovascular outcomes, especially in overcoming the paucity of conventional SES measures in commonly used datasets.


Assuntos
Habitação , Infarto do Miocárdio/epidemiologia , Infarto do Miocárdio/mortalidade , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Minnesota , Infarto do Miocárdio/etiologia , Modelos de Riscos Proporcionais , Fatores de Risco , Fatores Socioeconômicos
14.
Personal Disord ; 5(3): 323-33, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24512457

RESUMO

Narcissistic personality disorder (NPD) is associated with an assortment of characteristics that undermine interpersonal functioning. A lack of empathy is often cited as the primary distinguishing feature of NPD. However, clinical presentations of NPD suggest that empathy is not simply deficient in these individuals, but dysfunctional and subject to a diverse set of motivational and situational factors. Consistent with this presentation, research illustrates that empathy is multidimensional, involving 2 distinct emotional and cognitive processes associated with a capacity to respectively understand and respond to others' mental and affective states. The goal of this practice review is to bridge the gap between our psychobiological understanding of empathy and its clinical manifestations in NPD. We present 3 case studies highlighting the variability in empathic functioning in people with NPD. Additionally, we summarize the literature on empathy and NPD, which largely associates this disorder with deficient emotional empathy, and dysfunctional rather than deficient cognitive empathy. Because this research is limited, we also present empathy-based findings for related syndromes (borderline and psychopathy). Given the complexity of narcissism and empathy, we propose that multiple relationships can exist between these constructs. Ultimately, by recognizing the multifaceted relationship between empathy and narcissism, and moving away from an all or nothing belief that those with NPD simply lack empathy, therapists may better understand narcissistic patients' behavior and motivational structure.


Assuntos
Empatia/fisiologia , Transtornos da Personalidade/fisiopatologia , Adulto , Empatia/classificação , Feminino , Humanos , Masculino , Transtornos da Personalidade/terapia
15.
Biol Psychol ; 96: 86-93, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24355244

RESUMO

The P3 amplitude reduction is one of the most common correlates of externalizing. However, few studies have used experimental manipulations designed to challenge different cognitive functions in order to clarify the processes that impact this reduction. To examine factors moderating P3 amplitude in trait externalizing, we administered an n-back task that manipulated cognitive control demands, working memory load, and incentives to a sample of male offenders. Offenders with high trait externalizing scores did not display a global reduction in P3 amplitude. Rather, the negative association between trait externalizing and P3 amplitude was specific to trials involving inhibition of a dominant response during infrequent stimuli, in the context of low working memory load, and incentives for performance. In addition, we discuss the potential implications of these findings for externalizing-related psychopathologies. The results complement and expand previous work on the process-level dysfunction contributing to externalizing-related deficits in P3.


Assuntos
Cognição/fisiologia , Potenciais Evocados P300/fisiologia , Controle Interno-Externo , Memória de Curto Prazo/fisiologia , Motivação , Prisioneiros/psicologia , Adolescente , Adulto , Eletroencefalografia , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Personalidade , Transtornos Relacionados ao Uso de Substâncias/psicologia , Inquéritos e Questionários , Adulto Jovem
16.
J Neurosci ; 33(39): 15324-32, 2013 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-24068799

RESUMO

Phylogenetically the most ancient sense, olfaction is characterized by a unique intimacy with the emotion system. However, mechanisms underlying olfaction-emotion interaction remain unclear, especially in an ever-changing environment and dynamic internal milieu. Perturbing the internal state with anxiety induction in human subjects, we interrogated emotion-state-dependent olfactory processing in a functional magnetic resonance imaging (fMRI) study. Following anxiety induction, initially neutral odors become unpleasant and take longer to detect, accompanied by augmented response to these odors in the olfactory (anterior piriform and orbitofrontal) cortices and emotion-relevant pregenual anterior cingulate cortex. In parallel, the olfactory sensory relay adapts with increased anxiety, incorporating amygdala as an integral step via strengthened (afferent or efferent) connections between amygdala and all levels of the olfactory cortical hierarchy. This anxiety-state-dependent neural circuitry thus enables cumulative infusion of limbic affective information throughout the olfactory sensory progression, thereby driving affectively charged olfactory perception. These findings could constitute an olfactory etiology model of emotional disorders, as exaggerated emotion-olfaction interaction in negative mood states turns innocuous odors aversive, fueling anxiety and depression with rising ambient sensory stress.


Assuntos
Adaptação Fisiológica , Ansiedade/fisiopatologia , Rede Nervosa/fisiologia , Percepção Olfatória , Olfato , Adolescente , Adulto , Tonsila do Cerebelo/fisiologia , Ansiedade/psicologia , Córtex Cerebral/fisiologia , Feminino , Humanos , Masculino , Odorantes
17.
J Neurosci ; 33(2): 587-94, 2013 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-23303938

RESUMO

Threat evokes a variety of negative emotions such as fear, anger, and disgust. Whereas they elicit distinct and even opposite facial, sensory, and autonomic reflexes, threat-related emotions often converge in the actions they prompt (e.g., negative evaluation and avoidance). Here, we tested a unifying hypothesis that threat processing initially involves specialized encoding of individual subtypes to support discrete reflexive operations that later gives way to generalized elaborate analysis to facilitate convergent defensive behavior. Combining event-related potentials (ERPs) and a defensive context in human subjects, we compared temporal courses of perceptual analysis of two threat subtypes-fear and disgust. Indeed, fear enhanced and disgust suppressed early (115 ms) response in visual cortex, accentuating specialized sensory encoding of threat subtypes in accordance with the opposite behavioral and autonomic reflexes they typically elicit. By contrast, later ERP waveforms evoked by fear and disgust merged gradually over time (130-425 ms). Consistently, visual ERPs to anthropomorphic Greeble objects presented after fear versus disgust images also overlapped despite their clear departure from the neutral condition, paralleled by comparable exaggeration in Greeble imminence perception in the two threat (vs neutral) conditions. This later confluence of neural and behavioral response between fear and disgust thus highlights general threat categorization in high-level, downstream perception of threat. By delineating the temporal dynamics in perceiving individual threat emotions, our findings thus provide some of the first evidence to reconcile multidimensional and unidimensional aspects of information processing within the domain of threat, shedding new light on symptom heterogeneity across the anxiety disorder spectrum.


Assuntos
Medo/fisiologia , Generalização Psicológica/fisiologia , Percepção/fisiologia , Análise de Variância , Interpretação Estatística de Dados , Eletroencefalografia , Emoções/fisiologia , Potenciais Evocados/fisiologia , Expressão Facial , Feminino , Humanos , Julgamento , Imageamento por Ressonância Magnética , Masculino , Estimulação Luminosa , Reprodutibilidade dos Testes , Adulto Jovem
18.
Biol Psychol ; 92(2): 365-72, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23201037

RESUMO

Perceived control over a gambling outcome leads individuals to accept more and larger bets, increased risk-taking. Pathological gamblers, however, do not diminish risk-taking when control is absent, suggesting an illusion of control. To evaluate neural correlates of perceived control in gamblers, this study compared magnetoencephalography responses of 36 pathological (PG) and 36 non-pathological gamblers (NPG) during the Georgia Gambling Task. PGs exhibited greater activity in bilateral primary sensory regions. An interaction between pathology and control over the gambling task was observed bilaterally throughout dorsal and ventral visual processing streams, and lateral PFC. NPGs showed decreased activity when control was absent. Groups did not differ in response to potential bet cost. These findings provide neurophysiological evidence that PGs suffer from the pattern of risk-taking associated with perceived control, even when no control exists. They suggest that gambling pathology contributes to differential processing of gambling stimuli other than potential costs or rewards.


Assuntos
Mapeamento Encefálico , Encéfalo/fisiopatologia , Transtornos Cognitivos/etiologia , Transtornos Cognitivos/patologia , Tomada de Decisões/fisiologia , Jogo de Azar/complicações , Encéfalo/patologia , Feminino , Humanos , Imageamento Tridimensional , Julgamento , Magnetocardiografia , Masculino , Testes Neuropsicológicos , Tempo de Reação , Assunção de Riscos , Estudantes , Universidades
19.
Chemosens Percept ; 5(1): 37-45, 2012 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-22866182

RESUMO

The current conceptualization of threat processing in anxiety emphasizes emotional hyper-reactivity, which mediates various debilitating symptoms and derangements in anxiety disorders. Here, we investigated olfactory sensory perception of threat as an alternative causal mechanism of anxiety. Combining an event-related functional magnetic resonance imaging paradigm with an olfactory discrimination task, we examined how anxiety modulates basic perception of olfactory threats at behavioral and neural levels. In spite of subthreshold presentation of negative and neutral odors, a positive systematic association emerged between negative odor discrimination accuracy and anxiety levels. In parallel, the right olfactory primary (piriform) cortex indicated augmented response to subthreshold negative (vs. neutral) odors as a function of individual differences in anxiety. Using a psychophysiological interaction analysis, we further demonstrated amplified functional connectivity between the piriform cortex and emotion-related regions (amygdala and hippocampus) in response to negative odor, particularly in anxiety. Finally, anxiety also intensified skin conductance response to negative (vs. neutral) odor, indicative of potentiated emotional arousal to subliminal olfactory threat in anxiety. Together, these findings elucidate exaggerated processing of olfactory threat in anxiety across behavioral, autonomic physiological, and neural domains. Critically, our data emphasized anxiety-related hyper-sensitivity of the primary olfactory cortex and basic olfactory perception in response to threat, highlighting neurosensory mechanisms that may underlie the deleterious symptoms of anxiety.

20.
Eur J Pers ; 26(2): 123-132, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22611304

RESUMO

In the current paper, the authors posit that trait self-esteem moderates the relationship between social rejection and decrements in self-control, propose an information-processing account of trait self-esteem's moderating influence and discuss three tests of this theory. The authors measured trait self-esteem, experimentally manipulated social rejection and assessed subsequent self-control in Studies 1 and 2. Additionally, Study 3 framed a self-control task as diagnostic of social skills to examine motivational influences. Together, the results reveal that rejection impairs self-control, but only among low self-esteem individuals. Moreover, this decrement in self-control only emerged when the task had no social implications-suggesting that low self-esteem individuals exert effort on tasks of social value and are otherwise preoccupied with belonging needs when completing nonsocial tasks.

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